SZGR2

Summary ?

GeneID	2597
Symbol	GAPDH
Synonyms	G3PD\|GAPD\|HEL-S-162eP
Description	glyceraldehyde-3-phosphate dehydrogenase
Reference	MIM:138400\|HGNC:HGNC:4141\|Ensembl:ENSG00000111640\|HPRD:00713\|Vega:OTTHUMG00000137379
Gene type	protein-coding
Map location	12p13
Pascal p-value	0.733
Sherlock p-value	0.995
Fetal beta	-0.26
DMG	1 (# studies)
eGene	Frontal Cortex BA9
Support	CELL METABOLISM G2Cdb.human_mitochondria G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.6677

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg20917484	12	6644066	GAPDH	4.748E-4	-0.237	0.046	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003824	catalytic activity	IEA		-
GO:0005488	binding	IEA		-
GO:0005515	protein binding	IPI		17540579
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	IEA		-
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	NAS		3170585 \|7030790
GO:0016491	oxidoreductase activity	IEA		-
GO:0051287	NAD binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006096	glycolysis	NAS		-
GO:0006006	glucose metabolic process	IEA		-
GO:0008152	metabolic process	IEA		-
GO:0055114	oxidation reduction	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	NAS		-
GO:0016020	membrane	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APP	AAA \| ABETA \| ABPP \| AD1 \| APPI \| CTFgamma \| CVAP \| PN2	amyloid beta (A4) precursor protein	-	HPRD	8473906
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	8872471
ARL15	ARFRP2 \| FLJ20051	ADP-ribosylation factor-like 15	Two-hybrid	BioGRID	16169070
ATXN1	ATX1 \| D6S504E \| SCA1	ataxin 1	-	HPRD,BioGRID	8872471
BPGM	-	2,3-bisphosphoglycerate mutase	-	HPRD	9308888
BTBD2	-	BTB (POZ) domain containing 2	Two-hybrid	BioGRID	16169070
DYNLL1	DLC1 \| DLC8 \| DNCL1 \| DNCLC1 \| LC8 \| LC8a \| MGC126137 \| MGC126138 \| PIN \| hdlc1	dynein, light chain, LC8-type 1	-	HPRD	14760703
GAPDH	G3PD \| GAPD \| MGC88685	glyceraldehyde-3-phosphate dehydrogenase	-	HPRD	10617673
GRM1	GPRC1A \| GRM1A \| MGLUR1 \| MGLUR1A \| mGlu1	glutamate receptor, metabotropic 1	-	HPRD	9886087
HBXIP	MGC71071 \| XIP	hepatitis B virus x interacting protein	Two-hybrid	BioGRID	16169070
HTT	HD \| IT15	huntingtin	-	HPRD,BioGRID	8612237
LAMA4	DKFZp686D23145 \| LAMA3 \| LAMA4*-1	laminin, alpha 4	Two-hybrid	BioGRID	16169070
NPAT	E14	nuclear protein, ataxia-telangiectasia locus	Affinity Capture-Western	BioGRID	12887926
PAFAH1B3	-	platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa	Two-hybrid	BioGRID	16169070
PCDHA4	CNR1 \| CNRN1 \| CRNR1 \| MGC138307 \| MGC142169 \| PCDH-ALPHA4	protocadherin alpha 4	Two-hybrid	BioGRID	16169070
PDIA2	PDA2 \| PDI \| PDIP \| PDIR	protein disulfide isomerase family A, member 2	-	HPRD,BioGRID	11488911
PGK1	MGC117307 \| MGC142128 \| MGC8947 \| MIG10 \| PGKA	phosphoglycerate kinase 1	-	HPRD,BioGRID	8075252
PLD2	-	phospholipase D2	-	HPRD,BioGRID	12753082
POU2F1	OCT1 \| OTF1	POU class 2 homeobox 1	Affinity Capture-Western Reconstituted Complex	BioGRID	12887926
POU2F2	OCT2 \| OTF2 \| Oct-2	POU class 2 homeobox 2	Reconstituted Complex	BioGRID	12887926
PRDX1	MSP23 \| NKEFA \| PAG \| PAGA \| PAGB \| PRX1 \| PRXI \| TDPX2	peroxiredoxin 1	Two-hybrid	BioGRID	16169070
PRKCI	DXS1179E \| MGC26534 \| PKCI \| nPKC-iota	protein kinase C, iota	-	HPRD,BioGRID	11724794
PRKG1	CGKI \| DKFZp686K042 \| FLJ36117 \| MGC71944 \| PGK \| PKG \| PRKG1B \| PRKGR1B \| cGKI-BETA \| cGKI-alpha	protein kinase, cGMP-dependent, type I	Affinity Capture-Western	BioGRID	9308888
PSMD11	MGC3844 \| Rpn6 \| S9 \| p44.5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Two-hybrid	BioGRID	16169070
QRICH2	DKFZp434P0316	glutamine rich 2	Affinity Capture-MS	BioGRID	17353931
RPA2	REPA2 \| RPA32	replication protein A2, 32kDa	Two-hybrid	BioGRID	16169070
S100A6	2A9 \| 5B10 \| CABP \| CACY \| PRA	S100 calcium binding protein A6	-	HPRD	1999197
SERPINB9	CAP-3 \| CAP3 \| PI9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	Two-hybrid	BioGRID	16169070
SLC2A1	DYT17 \| DYT18 \| GLUT \| GLUT1 \| MGC141895 \| MGC141896 \| PED	solute carrier family 2 (facilitated glucose transporter), member 1	-	HPRD,BioGRID	2394733
STIP1	HOP \| IEF-SSP-3521 \| P60 \| STI1 \| STI1L	stress-induced-phosphoprotein 1	Affinity Capture-Western	BioGRID	12887926
SYNCRIP	GRY-RBP \| HNRPQ1 \| NSAP1 \| RP1-3J17.2 \| dJ3J17.2 \| hnRNP-Q \| pp68	synaptotagmin binding, cytoplasmic RNA interacting protein	NSAP-1 interacts with GAPDH.	BIND	15479637
TK1	TK2	thymidine kinase 1, soluble	Two-hybrid	BioGRID	16169070
TXN	DKFZp686B1993 \| MGC61975 \| TRX \| TRX1	thioredoxin	Affinity Capture-MS	BioGRID	17353931

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG GLYCOLYSIS GLUCONEOGENESIS	62	41	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
BIOCARTA MTA3 PATHWAY	19	10	All SZGR 2.0 genes in this pathway
BIOCARTA GLYCOLYSIS PATHWAY	10	9	All SZGR 2.0 genes in this pathway
WNT SIGNALING	89	71	All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY	79	62	All SZGR 2.0 genes in this pathway
REACTOME GLYCOLYSIS	29	18	All SZGR 2.0 genes in this pathway
REACTOME GLUCONEOGENESIS	34	21	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES	247	154	All SZGR 2.0 genes in this pathway
REACTOME GLUCOSE METABOLISM	69	42	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA UP	92	57	All SZGR 2.0 genes in this pathway
KORKOLA EMBRYONAL CARCINOMA UP	41	27	All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR UP	20	14	All SZGR 2.0 genes in this pathway
KORKOLA CHORIOCARCINOMA UP	6	5	All SZGR 2.0 genes in this pathway
KORKOLA SEMINOMA UP	44	27	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN	116	79	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR UP	27	19	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP	55	34	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 UP	58	39	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
DACOSTA LOW DOSE UV RESPONSE VIA ERCC3 XPCS DN	9	6	All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE DN	32	22	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS	88	60	All SZGR 2.0 genes in this pathway
GROSS HIF1A TARGETS DN	25	15	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN	110	78	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE UP	80	54	All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN	76	52	All SZGR 2.0 genes in this pathway
SHIPP DLBCL CURED VS FATAL DN	45	30	All SZGR 2.0 genes in this pathway
GNATENKO PLATELET SIGNATURE	48	28	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP	87	58	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN	51	35	All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN	85	67	All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN	87	57	All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP	81	52	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM UP	45	33	All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO METHOTREXATE DN	27	19	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA	81	64	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN	52	33	All SZGR 2.0 genes in this pathway
MACLACHLAN BRCA1 TARGETS UP	21	16	All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO CAMPTOTHECIN DN	46	31	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP	71	48	All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS	36	32	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2	118	65	All SZGR 2.0 genes in this pathway
HONMA DOCETAXEL RESISTANCE	34	23	All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS	116	63	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP	294	199	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 DN	240	153	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
NGO MALIGNANT GLIOMA 1P LOH	17	13	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP	221	135	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14	143	86	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16	79	47	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB	145	83	All SZGR 2.0 genes in this pathway
WANG ADIPOGENIC GENES REPRESSED BY SIRT1	28	21	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D	280	158	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP	146	75	All SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE B ALL DN	12	8	All SZGR 2.0 genes in this pathway

Gene Page: GAPDH