Gene Page: GAS8
Summary ?
| GeneID | 2622 |
| Symbol | GAS8 |
| Synonyms | CILD33|DRC4|GAS11 |
| Description | growth arrest specific 8 |
| Reference | MIM:605178|HGNC:HGNC:4166|Ensembl:ENSG00000141013|HPRD:05533|Vega:OTTHUMG00000138988 |
| Gene type | protein-coding |
| Map location | 16q24.3 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.728 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs12064275 | chr1 | 167160582 | GAS8 | 2622 | 0.15 | trans | ||
| rs11005394 | chr10 | 58296223 | GAS8 | 2622 | 0.15 | trans | ||
| rs12353619 | chrX | 118408162 | GAS8 | 2622 | 0.02 | trans | ||
| rs164752 | 16 | 89722390 | GAS8 | ENSG00000141013.10 | 1.252E-6 | 0.02 | -364848 | gtex_brain_ba24 |
| rs71274590 | 16 | 89795917 | GAS8 | ENSG00000141013.10 | 2.765E-6 | 0.02 | -291321 | gtex_brain_ba24 |
| rs77603042 | 16 | 90083239 | GAS8 | ENSG00000141013.10 | 9.228E-7 | 0.02 | -3999 | gtex_brain_ba24 |
| rs76265950 | 16 | 90085139 | GAS8 | ENSG00000141013.10 | 9.517E-7 | 0.02 | -2099 | gtex_brain_ba24 |
| rs77270200 | 16 | 90093075 | GAS8 | ENSG00000141013.10 | 1.057E-6 | 0.02 | 5837 | gtex_brain_ba24 |
| rs67689854 | 16 | 89625227 | GAS8 | ENSG00000141013.10 | 2.612E-6 | 0 | -462011 | gtex_brain_putamen_basal |
| rs397564 | 16 | 89656163 | GAS8 | ENSG00000141013.10 | 3.209E-6 | 0 | -431075 | gtex_brain_putamen_basal |
| rs464349 | 16 | 89656251 | GAS8 | ENSG00000141013.10 | 2.964E-6 | 0 | -430987 | gtex_brain_putamen_basal |
| rs464274 | 16 | 89656631 | GAS8 | ENSG00000141013.10 | 2.953E-6 | 0 | -430607 | gtex_brain_putamen_basal |
| rs453528 | 16 | 89693761 | GAS8 | ENSG00000141013.10 | 3.392E-6 | 0 | -393477 | gtex_brain_putamen_basal |
| rs12921177 | 16 | 89708037 | GAS8 | ENSG00000141013.10 | 1.999E-7 | 0 | -379201 | gtex_brain_putamen_basal |
| rs71396949 | 16 | 89714844 | GAS8 | ENSG00000141013.10 | 5.71E-8 | 0 | -372394 | gtex_brain_putamen_basal |
| rs4968051 | 16 | 89714981 | GAS8 | ENSG00000141013.10 | 1.454E-6 | 0 | -372257 | gtex_brain_putamen_basal |
| rs35749174 | 16 | 89716493 | GAS8 | ENSG00000141013.10 | 5.574E-8 | 0 | -370745 | gtex_brain_putamen_basal |
| rs35850949 | 16 | 89720724 | GAS8 | ENSG00000141013.10 | 5.478E-8 | 0 | -366514 | gtex_brain_putamen_basal |
| rs113974432 | 16 | 89721135 | GAS8 | ENSG00000141013.10 | 1.882E-7 | 0 | -366103 | gtex_brain_putamen_basal |
| rs36093105 | 16 | 89723282 | GAS8 | ENSG00000141013.10 | 1.879E-7 | 0 | -363956 | gtex_brain_putamen_basal |
| rs34878706 | 16 | 89723870 | GAS8 | ENSG00000141013.10 | 1.876E-7 | 0 | -363368 | gtex_brain_putamen_basal |
| rs35415928 | 16 | 89724268 | GAS8 | ENSG00000141013.10 | 6.644E-7 | 0 | -362970 | gtex_brain_putamen_basal |
| rs71396950 | 16 | 89726550 | GAS8 | ENSG00000141013.10 | 5.412E-8 | 0 | -360688 | gtex_brain_putamen_basal |
| rs71396951 | 16 | 89726593 | GAS8 | ENSG00000141013.10 | 5.412E-8 | 0 | -360645 | gtex_brain_putamen_basal |
| rs34526810 | 16 | 89728475 | GAS8 | ENSG00000141013.10 | 2.094E-7 | 0 | -358763 | gtex_brain_putamen_basal |
| rs187283 | 16 | 89729336 | GAS8 | ENSG00000141013.10 | 3.352E-6 | 0 | -357902 | gtex_brain_putamen_basal |
| rs77646997 | 16 | 89731905 | GAS8 | ENSG00000141013.10 | 2.146E-7 | 0 | -355333 | gtex_brain_putamen_basal |
| rs4785702 | 16 | 89733206 | GAS8 | ENSG00000141013.10 | 2.169E-7 | 0 | -354032 | gtex_brain_putamen_basal |
| rs35063026 | 16 | 89736157 | GAS8 | ENSG00000141013.10 | 5.393E-8 | 0 | -351081 | gtex_brain_putamen_basal |
| rs12918773 | 16 | 89741403 | GAS8 | ENSG00000141013.10 | 2.181E-7 | 0 | -345835 | gtex_brain_putamen_basal |
| rs12922197 | 16 | 89744809 | GAS8 | ENSG00000141013.10 | 2.175E-7 | 0 | -342429 | gtex_brain_putamen_basal |
| rs4785704 | 16 | 89772370 | GAS8 | ENSG00000141013.10 | 7.255E-7 | 0 | -314868 | gtex_brain_putamen_basal |
| rs34714188 | 16 | 89781756 | GAS8 | ENSG00000141013.10 | 4.683E-8 | 0 | -305482 | gtex_brain_putamen_basal |
| rs56283750 | 16 | 89786761 | GAS8 | ENSG00000141013.10 | 2.811E-6 | 0 | -300477 | gtex_brain_putamen_basal |
| rs6500437 | 16 | 89789898 | GAS8 | ENSG00000141013.10 | 1.63E-6 | 0 | -297340 | gtex_brain_putamen_basal |
| rs7189711 | 16 | 89791020 | GAS8 | ENSG00000141013.10 | 1.157E-6 | 0 | -296218 | gtex_brain_putamen_basal |
| rs12924124 | 16 | 89791126 | GAS8 | ENSG00000141013.10 | 5.412E-8 | 0 | -296112 | gtex_brain_putamen_basal |
| rs35026726 | 16 | 89791279 | GAS8 | ENSG00000141013.10 | 5.412E-8 | 0 | -295959 | gtex_brain_putamen_basal |
| rs12051515 | 16 | 89792491 | GAS8 | ENSG00000141013.10 | 1.916E-6 | 0 | -294747 | gtex_brain_putamen_basal |
| rs12925026 | 16 | 89792856 | GAS8 | ENSG00000141013.10 | 5.203E-8 | 0 | -294382 | gtex_brain_putamen_basal |
| rs9941108 | 16 | 89794932 | GAS8 | ENSG00000141013.10 | 2.803E-6 | 0 | -292306 | gtex_brain_putamen_basal |
| rs74606487 | 16 | 89795305 | GAS8 | ENSG00000141013.10 | 8.853E-7 | 0 | -291933 | gtex_brain_putamen_basal |
| rs79139787 | 16 | 89795360 | GAS8 | ENSG00000141013.10 | 4.455E-8 | 0 | -291878 | gtex_brain_putamen_basal |
| rs71274590 | 16 | 89795917 | GAS8 | ENSG00000141013.10 | 2.961E-6 | 0 | -291321 | gtex_brain_putamen_basal |
| rs34659644 | 16 | 89796017 | GAS8 | ENSG00000141013.10 | 5.412E-8 | 0 | -291221 | gtex_brain_putamen_basal |
| rs4785591 | 16 | 89797513 | GAS8 | ENSG00000141013.10 | 2.153E-6 | 0 | -289725 | gtex_brain_putamen_basal |
| rs4785592 | 16 | 89797515 | GAS8 | ENSG00000141013.10 | 2.17E-6 | 0 | -289723 | gtex_brain_putamen_basal |
| rs4785715 | 16 | 89800135 | GAS8 | ENSG00000141013.10 | 2.451E-6 | 0 | -287103 | gtex_brain_putamen_basal |
| rs5818726 | 16 | 89801920 | GAS8 | ENSG00000141013.10 | 3.117E-6 | 0 | -285318 | gtex_brain_putamen_basal |
| rs75207004 | 16 | 89802965 | GAS8 | ENSG00000141013.10 | 3.132E-6 | 0 | -284273 | gtex_brain_putamen_basal |
| rs12931267 | 16 | 89818732 | GAS8 | ENSG00000141013.10 | 5.632E-8 | 0 | -268506 | gtex_brain_putamen_basal |
| rs7205518 | 16 | 89819616 | GAS8 | ENSG00000141013.10 | 3.409E-6 | 0 | -267622 | gtex_brain_putamen_basal |
| rs7205519 | 16 | 89819816 | GAS8 | ENSG00000141013.10 | 1.217E-6 | 0 | -267422 | gtex_brain_putamen_basal |
| rs17226953 | 16 | 89825662 | GAS8 | ENSG00000141013.10 | 2.348E-6 | 0 | -261576 | gtex_brain_putamen_basal |
| rs78904586 | 16 | 89828043 | GAS8 | ENSG00000141013.10 | 2.579E-6 | 0 | -259195 | gtex_brain_putamen_basal |
| rs12929831 | 16 | 89830493 | GAS8 | ENSG00000141013.10 | 1.567E-6 | 0 | -256745 | gtex_brain_putamen_basal |
| rs200987001 | 16 | 89832409 | GAS8 | ENSG00000141013.10 | 6.661E-8 | 0 | -254829 | gtex_brain_putamen_basal |
| rs147126022 | 16 | 89832410 | GAS8 | ENSG00000141013.10 | 1.627E-7 | 0 | -254828 | gtex_brain_putamen_basal |
| rs1010356 | 16 | 89835097 | GAS8 | ENSG00000141013.10 | 2.502E-6 | 0 | -252141 | gtex_brain_putamen_basal |
| rs3785275 | 16 | 89842029 | GAS8 | ENSG00000141013.10 | 2.301E-6 | 0 | -245209 | gtex_brain_putamen_basal |
| rs1974571 | 16 | 89842824 | GAS8 | ENSG00000141013.10 | 2.198E-6 | 0 | -244414 | gtex_brain_putamen_basal |
| rs1006547 | 16 | 89844229 | GAS8 | ENSG00000141013.10 | 1.967E-6 | 0 | -243009 | gtex_brain_putamen_basal |
| rs34488586 | 16 | 89855717 | GAS8 | ENSG00000141013.10 | 2.713E-6 | 0 | -231521 | gtex_brain_putamen_basal |
| rs6500452 | 16 | 89858505 | GAS8 | ENSG00000141013.10 | 2.745E-6 | 0 | -228733 | gtex_brain_putamen_basal |
| rs12921383 | 16 | 89859753 | GAS8 | ENSG00000141013.10 | 2.238E-6 | 0 | -227485 | gtex_brain_putamen_basal |
| rs66531155 | 16 | 89860181 | GAS8 | ENSG00000141013.10 | 3.51E-6 | 0 | -227057 | gtex_brain_putamen_basal |
| rs1987271 | 16 | 89860183 | GAS8 | ENSG00000141013.10 | 2.457E-6 | 0 | -227055 | gtex_brain_putamen_basal |
| rs4785722 | 16 | 89863110 | GAS8 | ENSG00000141013.10 | 3.496E-6 | 0 | -224128 | gtex_brain_putamen_basal |
| rs1079558 | 16 | 89908003 | GAS8 | ENSG00000141013.10 | 2.159E-7 | 0 | -179235 | gtex_brain_putamen_basal |
| rs11076639 | 16 | 89912399 | GAS8 | ENSG00000141013.10 | 7.823E-7 | 0 | -174839 | gtex_brain_putamen_basal |
| rs9745545 | 16 | 89912457 | GAS8 | ENSG00000141013.10 | 3.032E-6 | 0 | -174781 | gtex_brain_putamen_basal |
| rs1805007 | 16 | 89986117 | GAS8 | ENSG00000141013.10 | 5.412E-8 | 0 | -101121 | gtex_brain_putamen_basal |
| rs146972365 | 16 | 90022693 | GAS8 | ENSG00000141013.10 | 5.067E-7 | 0 | -64545 | gtex_brain_putamen_basal |
| rs113891247 | 16 | 90047757 | GAS8 | ENSG00000141013.10 | 1.453E-7 | 0 | -39481 | gtex_brain_putamen_basal |
| rs45610233 | 16 | 90048395 | GAS8 | ENSG00000141013.10 | 1.453E-7 | 0 | -38843 | gtex_brain_putamen_basal |
| rs201156703 | 16 | 90052185 | GAS8 | ENSG00000141013.10 | 1.426E-7 | 0 | -35053 | gtex_brain_putamen_basal |
| rs73283859 | 16 | 90062520 | GAS8 | ENSG00000141013.10 | 3.314E-6 | 0 | -24718 | gtex_brain_putamen_basal |
| rs75319471 | 16 | 90064454 | GAS8 | ENSG00000141013.10 | 2.364E-6 | 0 | -22784 | gtex_brain_putamen_basal |
| rs73283869 | 16 | 90067184 | GAS8 | ENSG00000141013.10 | 3.314E-6 | 0 | -20054 | gtex_brain_putamen_basal |
| rs140889249 | 16 | 90069832 | GAS8 | ENSG00000141013.10 | 1.327E-6 | 0 | -17406 | gtex_brain_putamen_basal |
| rs77381714 | 16 | 90078022 | GAS8 | ENSG00000141013.10 | 1.453E-7 | 0 | -9216 | gtex_brain_putamen_basal |
| rs77603042 | 16 | 90083239 | GAS8 | ENSG00000141013.10 | 1.477E-7 | 0 | -3999 | gtex_brain_putamen_basal |
| rs76265950 | 16 | 90085139 | GAS8 | ENSG00000141013.10 | 4.263E-7 | 0 | -2099 | gtex_brain_putamen_basal |
| rs77270200 | 16 | 90093075 | GAS8 | ENSG00000141013.10 | 1.453E-7 | 0 | 5837 | gtex_brain_putamen_basal |
| rs78536691 | 16 | 90100471 | GAS8 | ENSG00000141013.10 | 1.577E-7 | 0 | 13233 | gtex_brain_putamen_basal |
| rs79418450 | 16 | 90100505 | GAS8 | ENSG00000141013.10 | 1.577E-7 | 0 | 13267 | gtex_brain_putamen_basal |
| rs74583214 | 16 | 90110798 | GAS8 | ENSG00000141013.10 | 1.103E-7 | 0 | 23560 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LIU SOX4 TARGETS DN | 309 | 191 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| ROYLANCE BREAST CANCER 16Q COPY NUMBER UP | 63 | 44 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN | 206 | 136 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC TARGETS WITH EBOX | 230 | 156 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 16Q24 AMPLICON | 53 | 38 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| SANSOM APC MYC TARGETS | 217 | 138 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS REQUIRE MYC | 210 | 123 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE EARLY LATE | 317 | 190 | All SZGR 2.0 genes in this pathway |
| DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |