Gene Page: FGF20
Summary ?
| GeneID | 26281 |
| Symbol | FGF20 |
| Synonyms | FGF-20|RHDA2 |
| Description | fibroblast growth factor 20 |
| Reference | MIM:605558|HGNC:HGNC:3677|HPRD:05709| |
| Gene type | protein-coding |
| Map location | 8p22 |
| Pascal p-value | 0.965 |
| Fetal beta | -1.036 |
| DMG | 1 (# studies) |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.031 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.00057 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.03086 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg02695780 | 8 | 16859295 | FGF20 | 1.741E-4 | -0.292 | 0.033 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0008083 | growth factor activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016049 | cell growth | IMP | 15592430 | |
| GO:0007267 | cell-cell signaling | TAS | 10913340 | |
| GO:0007165 | signal transduction | TAS | 10913340 | |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | EXP | 17133345 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | EXP | 1697263 |9139660 |11294897 |16597617 | |
| GO:0005576 | extracellular region | TAS | 10913340 | |
| GO:0005625 | soluble fraction | TAS | 10913340 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
| KEGG REGULATION OF ACTIN CYTOSKELETON | 216 | 144 | All SZGR 2.0 genes in this pathway |
| KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG MELANOMA | 71 | 57 | All SZGR 2.0 genes in this pathway |
| REACTOME NEGATIVE REGULATION OF FGFR SIGNALING | 37 | 24 | All SZGR 2.0 genes in this pathway |
| REACTOME INSULIN RECEPTOR SIGNALLING CASCADE | 87 | 64 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY FGFR IN DISEASE | 127 | 88 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | 16 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY FGFR1 MUTANTS | 30 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | 11 | 8 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY FGFR3 MUTANTS | 11 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY FGFR MUTANTS | 44 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME FRS2 MEDIATED CASCADE | 36 | 27 | All SZGR 2.0 genes in this pathway |
| REACTOME PI 3K CASCADE | 56 | 39 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR | 100 | 74 | All SZGR 2.0 genes in this pathway |
| REACTOME PHOSPHOLIPASE C MEDIATED CASCADE | 54 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME SHC MEDIATED CASCADE | 28 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY INSULIN RECEPTOR | 108 | 72 | All SZGR 2.0 genes in this pathway |
| REACTOME FGFR LIGAND BINDING AND ACTIVATION | 22 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | 12 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | 12 | 8 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY FGFR | 112 | 80 | All SZGR 2.0 genes in this pathway |
| REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | 14 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME PI3K CASCADE | 71 | 51 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K27ME3 | 269 | 159 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 6 UP | 140 | 81 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |
| NABA SECRETED FACTORS | 344 | 197 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |