Gene Page: AK5
Summary ?
| GeneID | 26289 |
| Symbol | AK5 |
| Synonyms | AK6 |
| Description | adenylate kinase 5 |
| Reference | MIM:608009|HGNC:HGNC:365|Ensembl:ENSG00000154027|HPRD:10472|Vega:OTTHUMG00000009796 |
| Gene type | protein-coding |
| Map location | 1p31 |
| Pascal p-value | 0.154 |
| Sherlock p-value | 0.298 |
| Fetal beta | -3.425 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cortex Frontal Cortex BA9 Putamen basal ganglia |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.02692 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00371134 | 1 | 77912654 | AK5 | 4.975E-4 | 0.279 | 0.047 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs114898412 | 1 | 78012427 | AK5 | ENSG00000154027.14 | 2.545E-8 | 0 | 264691 | gtex_brain_ba24 |
| rs6675743 | 1 | 78024284 | AK5 | ENSG00000154027.14 | 1.526E-6 | 0 | 276548 | gtex_brain_ba24 |
| rs10873950 | 1 | 78024602 | AK5 | ENSG00000154027.14 | 1.36E-6 | 0 | 276866 | gtex_brain_ba24 |
| rs3767031 | 1 | 78025047 | AK5 | ENSG00000154027.14 | 1.363E-6 | 0 | 277311 | gtex_brain_ba24 |
| rs3767030 | 1 | 78025049 | AK5 | ENSG00000154027.14 | 1.36E-6 | 0 | 277313 | gtex_brain_ba24 |
| rs4949811 | 1 | 78025454 | AK5 | ENSG00000154027.14 | 1.36E-6 | 0 | 277718 | gtex_brain_ba24 |
| rs4949813 | 1 | 78027725 | AK5 | ENSG00000154027.14 | 2.981E-7 | 0 | 279989 | gtex_brain_ba24 |
| rs962388 | 1 | 78029102 | AK5 | ENSG00000154027.14 | 7.196E-8 | 0 | 281366 | gtex_brain_ba24 |
| rs728741 | 1 | 78029365 | AK5 | ENSG00000154027.14 | 1.246E-6 | 0 | 281629 | gtex_brain_ba24 |
| rs1962523 | 1 | 78029905 | AK5 | ENSG00000154027.14 | 1.235E-6 | 0 | 282169 | gtex_brain_ba24 |
| rs12717767 | 1 | 78035163 | AK5 | ENSG00000154027.14 | 1.926E-6 | 0 | 287427 | gtex_brain_ba24 |
| rs12081426 | 1 | 78035856 | AK5 | ENSG00000154027.14 | 1.937E-6 | 0 | 288120 | gtex_brain_ba24 |
| rs6603955 | 1 | 78036974 | AK5 | ENSG00000154027.14 | 1.447E-6 | 0 | 289238 | gtex_brain_ba24 |
| rs4949816 | 1 | 78045897 | AK5 | ENSG00000154027.14 | 3.177E-6 | 0 | 298161 | gtex_brain_ba24 |
| rs17385754 | 1 | 78046630 | AK5 | ENSG00000154027.14 | 5.612E-8 | 0 | 298894 | gtex_brain_ba24 |
| rs12126604 | 1 | 78058385 | AK5 | ENSG00000154027.14 | 5.617E-8 | 0 | 310649 | gtex_brain_ba24 |
| rs10873951 | 1 | 78075766 | AK5 | ENSG00000154027.14 | 1.381E-6 | 0 | 328030 | gtex_brain_ba24 |
| rs11162369 | 1 | 78080362 | AK5 | ENSG00000154027.14 | 2.625E-6 | 0 | 332626 | gtex_brain_ba24 |
| rs11162372 | 1 | 78091293 | AK5 | ENSG00000154027.14 | 1.422E-6 | 0 | 343557 | gtex_brain_ba24 |
| rs371076 | 1 | 78122501 | AK5 | ENSG00000154027.14 | 1.43E-6 | 0 | 374765 | gtex_brain_ba24 |
| rs278852 | 1 | 78127554 | AK5 | ENSG00000154027.14 | 1.121E-6 | 0 | 379818 | gtex_brain_ba24 |
| rs278854 | 1 | 78132534 | AK5 | ENSG00000154027.14 | 1.43E-6 | 0 | 384798 | gtex_brain_ba24 |
| rs67139134 | 1 | 78151240 | AK5 | ENSG00000154027.14 | 1.43E-6 | 0 | 403504 | gtex_brain_ba24 |
| rs278845 | 1 | 78152805 | AK5 | ENSG00000154027.14 | 1.192E-6 | 0 | 405069 | gtex_brain_ba24 |
| rs278847 | 1 | 78153821 | AK5 | ENSG00000154027.14 | 1.43E-6 | 0 | 406085 | gtex_brain_ba24 |
| rs7521042 | 1 | 78164339 | AK5 | ENSG00000154027.14 | 1.43E-6 | 0 | 416603 | gtex_brain_ba24 |
| rs6693100 | 1 | 78175022 | AK5 | ENSG00000154027.14 | 1.43E-6 | 0 | 427286 | gtex_brain_ba24 |
| rs12142671 | 1 | 78184325 | AK5 | ENSG00000154027.14 | 1.43E-6 | 0 | 436589 | gtex_brain_ba24 |
| rs12121287 | 1 | 78201889 | AK5 | ENSG00000154027.14 | 2.535E-7 | 0 | 454153 | gtex_brain_ba24 |
| rs2147318 | 1 | 78242638 | AK5 | ENSG00000154027.14 | 9.182E-7 | 0 | 494902 | gtex_brain_ba24 |
| rs12120236 | 1 | 78253741 | AK5 | ENSG00000154027.14 | 5.712E-8 | 0 | 506005 | gtex_brain_ba24 |
| rs1166588 | 1 | 78254258 | AK5 | ENSG00000154027.14 | 2.423E-6 | 0 | 506522 | gtex_brain_ba24 |
| rs1166585 | 1 | 78259721 | AK5 | ENSG00000154027.14 | 1.038E-6 | 0 | 511985 | gtex_brain_ba24 |
| rs1166584 | 1 | 78261825 | AK5 | ENSG00000154027.14 | 2.441E-7 | 0 | 514089 | gtex_brain_ba24 |
| rs12122686 | 1 | 78264259 | AK5 | ENSG00000154027.14 | 7.071E-8 | 0 | 516523 | gtex_brain_ba24 |
| rs1977900 | 1 | 78281741 | AK5 | ENSG00000154027.14 | 2.473E-7 | 0 | 534005 | gtex_brain_ba24 |
| rs6700924 | 1 | 78282983 | AK5 | ENSG00000154027.14 | 5.721E-8 | 0 | 535247 | gtex_brain_ba24 |
| rs143463878 | 1 | 78448840 | AK5 | ENSG00000154027.14 | 3.46E-6 | 0 | 701104 | gtex_brain_ba24 |
| rs200769174 | 1 | 78481236 | AK5 | ENSG00000154027.14 | 1.309E-7 | 0 | 733500 | gtex_brain_ba24 |
| rs1964711 | 1 | 78481511 | AK5 | ENSG00000154027.14 | 1.983E-6 | 0 | 733775 | gtex_brain_ba24 |
| rs61524266 | 1 | 78506972 | AK5 | ENSG00000154027.14 | 2.155E-7 | 0 | 759236 | gtex_brain_ba24 |
| rs61777265 | 1 | 78530478 | AK5 | ENSG00000154027.14 | 3.363E-6 | 0 | 782742 | gtex_brain_ba24 |
| rs11162413 | 1 | 78547098 | AK5 | ENSG00000154027.14 | 2.926E-6 | 0 | 799362 | gtex_brain_ba24 |
| rs4949657 | 1 | 77991508 | AK5 | ENSG00000154027.14 | 4.17E-6 | 0.01 | 243772 | gtex_brain_putamen_basal |
| rs2803136 | 1 | 77992695 | AK5 | ENSG00000154027.14 | 6.693E-7 | 0.01 | 244959 | gtex_brain_putamen_basal |
| rs1976334 | 1 | 77993472 | AK5 | ENSG00000154027.14 | 6.68E-7 | 0.01 | 245736 | gtex_brain_putamen_basal |
| rs1013399 | 1 | 77994993 | AK5 | ENSG00000154027.14 | 1.16E-6 | 0.01 | 247257 | gtex_brain_putamen_basal |
| rs2133202 | 1 | 77995041 | AK5 | ENSG00000154027.14 | 3.29E-6 | 0.01 | 247305 | gtex_brain_putamen_basal |
| rs2647487 | 1 | 77996778 | AK5 | ENSG00000154027.14 | 1.224E-6 | 0.01 | 249042 | gtex_brain_putamen_basal |
| rs2647486 | 1 | 77999471 | AK5 | ENSG00000154027.14 | 1.161E-6 | 0.01 | 251735 | gtex_brain_putamen_basal |
| rs2803168 | 1 | 77999946 | AK5 | ENSG00000154027.14 | 1.162E-6 | 0.01 | 252210 | gtex_brain_putamen_basal |
| rs3738079 | 1 | 78001287 | AK5 | ENSG00000154027.14 | 1.162E-6 | 0.01 | 253551 | gtex_brain_putamen_basal |
| rs12095064 | 1 | 78001947 | AK5 | ENSG00000154027.14 | 4.511E-6 | 0.01 | 254211 | gtex_brain_putamen_basal |
| rs7551211 | 1 | 78003085 | AK5 | ENSG00000154027.14 | 1.212E-6 | 0.01 | 255349 | gtex_brain_putamen_basal |
| rs7551729 | 1 | 78003584 | AK5 | ENSG00000154027.14 | 1.227E-6 | 0.01 | 255848 | gtex_brain_putamen_basal |
| rs6696083 | 1 | 78006490 | AK5 | ENSG00000154027.14 | 3.019E-6 | 0.01 | 258754 | gtex_brain_putamen_basal |
| rs6603953 | 1 | 78006631 | AK5 | ENSG00000154027.14 | 6.764E-7 | 0.01 | 258895 | gtex_brain_putamen_basal |
| rs4949807 | 1 | 78007932 | AK5 | ENSG00000154027.14 | 1.004E-6 | 0.01 | 260196 | gtex_brain_putamen_basal |
| rs12724560 | 1 | 78008652 | AK5 | ENSG00000154027.14 | 7.92E-7 | 0.01 | 260916 | gtex_brain_putamen_basal |
| rs7519476 | 1 | 78010650 | AK5 | ENSG00000154027.14 | 8.418E-7 | 0.01 | 262914 | gtex_brain_putamen_basal |
| rs6667803 | 1 | 78012116 | AK5 | ENSG00000154027.14 | 3.175E-6 | 0.01 | 264380 | gtex_brain_putamen_basal |
| rs2029768 | 1 | 78014042 | AK5 | ENSG00000154027.14 | 2.974E-6 | 0.01 | 266306 | gtex_brain_putamen_basal |
| rs2172727 | 1 | 78016517 | AK5 | ENSG00000154027.14 | 2.062E-6 | 0.01 | 268781 | gtex_brain_putamen_basal |
| rs7528552 | 1 | 78019672 | AK5 | ENSG00000154027.14 | 8.857E-7 | 0.01 | 271936 | gtex_brain_putamen_basal |
| rs7524147 | 1 | 78019673 | AK5 | ENSG00000154027.14 | 1.074E-6 | 0.01 | 271937 | gtex_brain_putamen_basal |
| rs4949809 | 1 | 78021679 | AK5 | ENSG00000154027.14 | 4.551E-7 | 0.01 | 273943 | gtex_brain_putamen_basal |
| rs1565851 | 1 | 78022217 | AK5 | ENSG00000154027.14 | 8.092E-7 | 0.01 | 274481 | gtex_brain_putamen_basal |
| rs7524866 | 1 | 78022721 | AK5 | ENSG00000154027.14 | 1.998E-7 | 0.01 | 274985 | gtex_brain_putamen_basal |
| rs4245658 | 1 | 78022851 | AK5 | ENSG00000154027.14 | 8.158E-7 | 0.01 | 275115 | gtex_brain_putamen_basal |
| rs6667519 | 1 | 78023753 | AK5 | ENSG00000154027.14 | 4.279E-7 | 0.01 | 276017 | gtex_brain_putamen_basal |
| rs6675743 | 1 | 78024284 | AK5 | ENSG00000154027.14 | 2.028E-7 | 0.01 | 276548 | gtex_brain_putamen_basal |
| rs79671213 | 1 | 78024345 | AK5 | ENSG00000154027.14 | 6.55E-7 | 0.01 | 276609 | gtex_brain_putamen_basal |
| rs10873950 | 1 | 78024602 | AK5 | ENSG00000154027.14 | 1.998E-7 | 0.01 | 276866 | gtex_brain_putamen_basal |
| rs3767031 | 1 | 78025047 | AK5 | ENSG00000154027.14 | 2.001E-7 | 0.01 | 277311 | gtex_brain_putamen_basal |
| rs3767030 | 1 | 78025049 | AK5 | ENSG00000154027.14 | 1.998E-7 | 0.01 | 277313 | gtex_brain_putamen_basal |
| rs398053142 | 1 | 78025230 | AK5 | ENSG00000154027.14 | 4.475E-7 | 0.01 | 277494 | gtex_brain_putamen_basal |
| rs4949811 | 1 | 78025454 | AK5 | ENSG00000154027.14 | 1.998E-7 | 0.01 | 277718 | gtex_brain_putamen_basal |
| rs3509 | 1 | 78025551 | AK5 | ENSG00000154027.14 | 4.475E-7 | 0.01 | 277815 | gtex_brain_putamen_basal |
| rs4949813 | 1 | 78027725 | AK5 | ENSG00000154027.14 | 4.475E-7 | 0.01 | 279989 | gtex_brain_putamen_basal |
| rs962388 | 1 | 78029102 | AK5 | ENSG00000154027.14 | 1.652E-6 | 0.01 | 281366 | gtex_brain_putamen_basal |
| rs728741 | 1 | 78029365 | AK5 | ENSG00000154027.14 | 1.827E-6 | 0.01 | 281629 | gtex_brain_putamen_basal |
| rs1962523 | 1 | 78029905 | AK5 | ENSG00000154027.14 | 1.981E-6 | 0.01 | 282169 | gtex_brain_putamen_basal |
| rs7552291 | 1 | 78031994 | AK5 | ENSG00000154027.14 | 3.539E-6 | 0.01 | 284258 | gtex_brain_putamen_basal |
| rs530314782 | 1 | 78033981 | AK5 | ENSG00000154027.14 | 3.519E-6 | 0.01 | 286245 | gtex_brain_putamen_basal |
| rs11162366 | 1 | 78036366 | AK5 | ENSG00000154027.14 | 3.533E-6 | 0.01 | 288630 | gtex_brain_putamen_basal |
| rs4949814 | 1 | 78036688 | AK5 | ENSG00000154027.14 | 3.562E-6 | 0.01 | 288952 | gtex_brain_putamen_basal |
| rs6698151 | 1 | 78038609 | AK5 | ENSG00000154027.14 | 3.539E-6 | 0.01 | 290873 | gtex_brain_putamen_basal |
| rs6691317 | 1 | 78038898 | AK5 | ENSG00000154027.14 | 3.591E-6 | 0.01 | 291162 | gtex_brain_putamen_basal |
| rs7545175 | 1 | 78039737 | AK5 | ENSG00000154027.14 | 3.539E-6 | 0.01 | 292001 | gtex_brain_putamen_basal |
| rs4949661 | 1 | 78042523 | AK5 | ENSG00000154027.14 | 3.539E-6 | 0.01 | 294787 | gtex_brain_putamen_basal |
| rs6670660 | 1 | 78048698 | AK5 | ENSG00000154027.14 | 3.217E-6 | 0.01 | 300962 | gtex_brain_putamen_basal |
| rs9988619 | 1 | 78057291 | AK5 | ENSG00000154027.14 | 4.392E-6 | 0.01 | 309555 | gtex_brain_putamen_basal |
| rs12717768 | 1 | 78060096 | AK5 | ENSG00000154027.14 | 3.575E-6 | 0.01 | 312360 | gtex_brain_putamen_basal |
| rs7546365 | 1 | 78060456 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 312720 | gtex_brain_putamen_basal |
| rs872342 | 1 | 78064289 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 316553 | gtex_brain_putamen_basal |
| rs4949817 | 1 | 78070611 | AK5 | ENSG00000154027.14 | 3.53E-6 | 0.01 | 322875 | gtex_brain_putamen_basal |
| rs11162368 | 1 | 78074662 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 326926 | gtex_brain_putamen_basal |
| rs12026939 | 1 | 78075002 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 327266 | gtex_brain_putamen_basal |
| rs4949818 | 1 | 78078646 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 330910 | gtex_brain_putamen_basal |
| rs11162369 | 1 | 78080362 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 332626 | gtex_brain_putamen_basal |
| rs6603956 | 1 | 78083135 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 335399 | gtex_brain_putamen_basal |
| rs11162370 | 1 | 78084193 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 336457 | gtex_brain_putamen_basal |
| rs6657290 | 1 | 78085954 | AK5 | ENSG00000154027.14 | 2.129E-6 | 0.01 | 338218 | gtex_brain_putamen_basal |
| rs1389790 | 1 | 78089399 | AK5 | ENSG00000154027.14 | 3.581E-6 | 0.01 | 341663 | gtex_brain_putamen_basal |
| rs397713096 | 1 | 78090174 | AK5 | ENSG00000154027.14 | 3.527E-6 | 0.01 | 342438 | gtex_brain_putamen_basal |
| rs11162372 | 1 | 78091293 | AK5 | ENSG00000154027.14 | 3.453E-6 | 0.01 | 343557 | gtex_brain_putamen_basal |
| rs1389789 | 1 | 78094779 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 347043 | gtex_brain_putamen_basal |
| rs6674638 | 1 | 78094823 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 347087 | gtex_brain_putamen_basal |
| rs11162374 | 1 | 78101584 | AK5 | ENSG00000154027.14 | 3.139E-6 | 0.01 | 353848 | gtex_brain_putamen_basal |
| rs6699205 | 1 | 78102333 | AK5 | ENSG00000154027.14 | 3.458E-6 | 0.01 | 354597 | gtex_brain_putamen_basal |
| rs6699311 | 1 | 78102426 | AK5 | ENSG00000154027.14 | 3.478E-6 | 0.01 | 354690 | gtex_brain_putamen_basal |
| rs1038983 | 1 | 78104852 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 357116 | gtex_brain_putamen_basal |
| rs166770 | 1 | 78111153 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 363417 | gtex_brain_putamen_basal |
| rs7556523 | 1 | 78114568 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 366832 | gtex_brain_putamen_basal |
| rs6661656 | 1 | 78114984 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 367248 | gtex_brain_putamen_basal |
| rs278837 | 1 | 78116403 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 368667 | gtex_brain_putamen_basal |
| rs278836 | 1 | 78116811 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 369075 | gtex_brain_putamen_basal |
| rs278834 | 1 | 78119307 | AK5 | ENSG00000154027.14 | 3.552E-6 | 0.01 | 371571 | gtex_brain_putamen_basal |
| rs574973 | 1 | 78120181 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 372445 | gtex_brain_putamen_basal |
| rs371076 | 1 | 78122501 | AK5 | ENSG00000154027.14 | 3.448E-6 | 0.01 | 374765 | gtex_brain_putamen_basal |
| rs370335 | 1 | 78122686 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 374950 | gtex_brain_putamen_basal |
| rs366467 | 1 | 78122785 | AK5 | ENSG00000154027.14 | 2.215E-6 | 0.01 | 375049 | gtex_brain_putamen_basal |
| rs278850 | 1 | 78126044 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 378308 | gtex_brain_putamen_basal |
| rs278851 | 1 | 78126882 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 379146 | gtex_brain_putamen_basal |
| rs278854 | 1 | 78132534 | AK5 | ENSG00000154027.14 | 3.448E-6 | 0.01 | 384798 | gtex_brain_putamen_basal |
| rs278855 | 1 | 78133080 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 385344 | gtex_brain_putamen_basal |
| rs278856 | 1 | 78134935 | AK5 | ENSG00000154027.14 | 3.548E-6 | 0.01 | 387199 | gtex_brain_putamen_basal |
| rs278857 | 1 | 78135734 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 387998 | gtex_brain_putamen_basal |
| rs278858 | 1 | 78136592 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 388856 | gtex_brain_putamen_basal |
| rs278859 | 1 | 78136880 | AK5 | ENSG00000154027.14 | 2.123E-6 | 0.01 | 389144 | gtex_brain_putamen_basal |
| rs278860 | 1 | 78138955 | AK5 | ENSG00000154027.14 | 3.57E-6 | 0.01 | 391219 | gtex_brain_putamen_basal |
| rs278863 | 1 | 78142192 | AK5 | ENSG00000154027.14 | 3.57E-6 | 0.01 | 394456 | gtex_brain_putamen_basal |
| rs278864 | 1 | 78142567 | AK5 | ENSG00000154027.14 | 2.123E-6 | 0.01 | 394831 | gtex_brain_putamen_basal |
| rs278848 | 1 | 78143409 | AK5 | ENSG00000154027.14 | 3.57E-6 | 0.01 | 395673 | gtex_brain_putamen_basal |
| rs203229 | 1 | 78149941 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 402205 | gtex_brain_putamen_basal |
| rs278843 | 1 | 78150634 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 402898 | gtex_brain_putamen_basal |
| rs67139134 | 1 | 78151240 | AK5 | ENSG00000154027.14 | 3.448E-6 | 0.01 | 403504 | gtex_brain_putamen_basal |
| rs278844 | 1 | 78152668 | AK5 | ENSG00000154027.14 | 3.709E-6 | 0.01 | 404932 | gtex_brain_putamen_basal |
| rs278845 | 1 | 78152805 | AK5 | ENSG00000154027.14 | 1.58E-6 | 0.01 | 405069 | gtex_brain_putamen_basal |
| rs278847 | 1 | 78153821 | AK5 | ENSG00000154027.14 | 3.448E-6 | 0.01 | 406085 | gtex_brain_putamen_basal |
| rs278833 | 1 | 78157949 | AK5 | ENSG00000154027.14 | 2.027E-6 | 0.01 | 410213 | gtex_brain_putamen_basal |
| rs12135104 | 1 | 78164902 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 417166 | gtex_brain_putamen_basal |
| rs278842 | 1 | 78170574 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 422838 | gtex_brain_putamen_basal |
| rs278841 | 1 | 78171025 | AK5 | ENSG00000154027.14 | 4.252E-6 | 0.01 | 423289 | gtex_brain_putamen_basal |
| rs278840 | 1 | 78171290 | AK5 | ENSG00000154027.14 | 2.638E-6 | 0.01 | 423554 | gtex_brain_putamen_basal |
| rs6693100 | 1 | 78175022 | AK5 | ENSG00000154027.14 | 3.448E-6 | 0.01 | 427286 | gtex_brain_putamen_basal |
| rs6603958 | 1 | 78178976 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 431240 | gtex_brain_putamen_basal |
| rs9662527 | 1 | 78179213 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 431477 | gtex_brain_putamen_basal |
| rs11162378 | 1 | 78183861 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 436125 | gtex_brain_putamen_basal |
| rs12142671 | 1 | 78184325 | AK5 | ENSG00000154027.14 | 3.448E-6 | 0.01 | 436589 | gtex_brain_putamen_basal |
| rs10873953 | 1 | 78192490 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 444754 | gtex_brain_putamen_basal |
| rs11578805 | 1 | 78197120 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 449384 | gtex_brain_putamen_basal |
| rs3767037 | 1 | 78200005 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 452269 | gtex_brain_putamen_basal |
| rs2296227 | 1 | 78201745 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 454009 | gtex_brain_putamen_basal |
| rs11162380 | 1 | 78202741 | AK5 | ENSG00000154027.14 | 3.539E-6 | 0.01 | 455005 | gtex_brain_putamen_basal |
| rs6687501 | 1 | 78203519 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 455783 | gtex_brain_putamen_basal |
| rs6603960 | 1 | 78213434 | AK5 | ENSG00000154027.14 | 3.588E-6 | 0.01 | 465698 | gtex_brain_putamen_basal |
| rs717333 | 1 | 78219190 | AK5 | ENSG00000154027.14 | 3.579E-6 | 0.01 | 471454 | gtex_brain_putamen_basal |
| rs12132838 | 1 | 78220931 | AK5 | ENSG00000154027.14 | 3.579E-6 | 0.01 | 473195 | gtex_brain_putamen_basal |
| rs3767038 | 1 | 78225658 | AK5 | ENSG00000154027.14 | 3.58E-6 | 0.01 | 477922 | gtex_brain_putamen_basal |
| rs6672200 | 1 | 78225880 | AK5 | ENSG00000154027.14 | 2.119E-6 | 0.01 | 478144 | gtex_brain_putamen_basal |
| rs56688304 | 1 | 78233499 | AK5 | ENSG00000154027.14 | 2.118E-6 | 0.01 | 485763 | gtex_brain_putamen_basal |
| rs6687596 | 1 | 78233694 | AK5 | ENSG00000154027.14 | 2.118E-6 | 0.01 | 485958 | gtex_brain_putamen_basal |
| rs35356163 | 1 | 78239310 | AK5 | ENSG00000154027.14 | 1.831E-6 | 0.01 | 491574 | gtex_brain_putamen_basal |
| rs2031342 | 1 | 78240117 | AK5 | ENSG00000154027.14 | 3.581E-6 | 0.01 | 492381 | gtex_brain_putamen_basal |
| rs2147318 | 1 | 78242638 | AK5 | ENSG00000154027.14 | 1.899E-6 | 0.01 | 494902 | gtex_brain_putamen_basal |
| rs4488068 | 1 | 78242837 | AK5 | ENSG00000154027.14 | 3.557E-6 | 0.01 | 495101 | gtex_brain_putamen_basal |
| rs12142441 | 1 | 78243547 | AK5 | ENSG00000154027.14 | 3.562E-6 | 0.01 | 495811 | gtex_brain_putamen_basal |
| rs1166589 | 1 | 78253231 | AK5 | ENSG00000154027.14 | 7.728E-7 | 0.01 | 505495 | gtex_brain_putamen_basal |
| rs1166586 | 1 | 78257104 | AK5 | ENSG00000154027.14 | 2.126E-6 | 0.01 | 509368 | gtex_brain_putamen_basal |
| rs1166585 | 1 | 78259721 | AK5 | ENSG00000154027.14 | 1.414E-6 | 0.01 | 511985 | gtex_brain_putamen_basal |
| rs1166584 | 1 | 78261825 | AK5 | ENSG00000154027.14 | 3.994E-7 | 0.01 | 514089 | gtex_brain_putamen_basal |
| rs1539739 | 1 | 78266417 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 518681 | gtex_brain_putamen_basal |
| rs11162383 | 1 | 78270944 | AK5 | ENSG00000154027.14 | 2.119E-6 | 0.01 | 523208 | gtex_brain_putamen_basal |
| rs4949822 | 1 | 78272902 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 525166 | gtex_brain_putamen_basal |
| rs11162384 | 1 | 78277881 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 530145 | gtex_brain_putamen_basal |
| rs11162386 | 1 | 78281002 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 533266 | gtex_brain_putamen_basal |
| rs1977900 | 1 | 78281741 | AK5 | ENSG00000154027.14 | 3.66E-7 | 0.01 | 534005 | gtex_brain_putamen_basal |
| rs7543037 | 1 | 78283600 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 535864 | gtex_brain_putamen_basal |
| rs7543125 | 1 | 78283714 | AK5 | ENSG00000154027.14 | 2.122E-6 | 0.01 | 535978 | gtex_brain_putamen_basal |
| rs7556227 | 1 | 78283721 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 535985 | gtex_brain_putamen_basal |
| rs7536206 | 1 | 78283755 | AK5 | ENSG00000154027.14 | 3.572E-6 | 0.01 | 536019 | gtex_brain_putamen_basal |
| rs10873954 | 1 | 78284029 | AK5 | ENSG00000154027.14 | 3.699E-6 | 0.01 | 536293 | gtex_brain_putamen_basal |
| rs10873955 | 1 | 78284211 | AK5 | ENSG00000154027.14 | 2.125E-6 | 0.01 | 536475 | gtex_brain_putamen_basal |
| rs12090729 | 1 | 78286674 | AK5 | ENSG00000154027.14 | 3.534E-6 | 0.01 | 538938 | gtex_brain_putamen_basal |
| rs11162387 | 1 | 78287808 | AK5 | ENSG00000154027.14 | 2.079E-6 | 0.01 | 540072 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0004017 | adenylate kinase activity | IEA | - | |
| GO:0004017 | adenylate kinase activity | TAS | 10215863 | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0019205 | nucleobase, nucleoside, nucleotide kinase activity | IEA | - | |
| GO:0019206 | nucleoside kinase activity | EXP | 10215863 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006173 | dADP biosynthetic process | TAS | 10215863 | |
| GO:0006172 | ADP biosynthetic process | TAS | 10215863 | |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | IEA | - | |
| GO:0009220 | pyrimidine ribonucleotide biosynthetic process | TAS | 10215863 | |
| GO:0046034 | ATP metabolic process | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005829 | cytosol | EXP | 10215863 | |
| GO:0005829 | cytosol | TAS | 10215863 | |
| GO:0005737 | cytoplasm | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PURINE METABOLISM | 159 | 96 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF NUCLEOTIDES | 72 | 45 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | 19 | 10 | All SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN | 198 | 110 | All SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL DN | 69 | 43 | All SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL DN | 91 | 53 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP | 368 | 234 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN | 50 | 36 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| ROZANOV MMP14 TARGETS UP | 266 | 171 | All SZGR 2.0 genes in this pathway |
| ROSS AML WITH CBFB MYH11 FUSION | 52 | 32 | All SZGR 2.0 genes in this pathway |
| SANA TNF SIGNALING DN | 90 | 57 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K9ME3 UP | 141 | 75 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| LEE NAIVE T LYMPHOCYTE | 19 | 10 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 | 142 | 103 | All SZGR 2.0 genes in this pathway |
| VALK AML CLUSTER 9 | 35 | 26 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER DN | 134 | 83 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 | 210 | 148 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | All SZGR 2.0 genes in this pathway |
| HOELZEL NF1 TARGETS DN | 115 | 73 | All SZGR 2.0 genes in this pathway |
| MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN | 229 | 135 | All SZGR 2.0 genes in this pathway |
| KUMAR PATHOGEN LOAD BY MACROPHAGES | 275 | 155 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
| miRNA family | Target position | miRNA ID | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-493-5p | 1267 | 1274 | 1A,m8 | hsa-miR-493-5p | UUGUACAUGGUAGGCUUUCAUU |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.