Gene Page: GCKR
Summary ?
| GeneID | 2646 |
| Symbol | GCKR |
| Synonyms | FGQTL5|GKRP |
| Description | glucokinase (hexokinase 4) regulator |
| Reference | MIM:600842|HGNC:HGNC:4196|Ensembl:ENSG00000084734|HPRD:02909|Vega:OTTHUMG00000128426 |
| Gene type | protein-coding |
| Map location | 2p23 |
| Pascal p-value | 3.705E-4 |
| Fetal beta | 0.463 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SOSTDC1 | 0.75 | 0.66 |
| TM6SF1 | 0.72 | 0.60 |
| NPNT | 0.69 | 0.64 |
| SLC1A6 | 0.69 | 0.46 |
| MYO16 | 0.68 | 0.51 |
| FAM189A1 | 0.67 | 0.74 |
| GRP | 0.67 | 0.58 |
| TRIM7 | 0.66 | 0.70 |
| FRZB | 0.66 | 0.64 |
| GPR68 | 0.65 | 0.73 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C11orf67 | -0.29 | -0.25 |
| ANP32B | -0.28 | -0.39 |
| IMPA2 | -0.28 | -0.38 |
| AP002478.3 | -0.28 | -0.21 |
| AF347015.2 | -0.27 | -0.11 |
| CAPG | -0.27 | -0.33 |
| TMEM98 | -0.27 | -0.29 |
| MT-CO2 | -0.27 | -0.10 |
| RAB13 | -0.26 | -0.37 |
| AF347015.21 | -0.26 | -0.10 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 241 | 157 | All SZGR 2.0 genes in this pathway |
| REACTOME GLUCOSE TRANSPORT | 38 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF CARBOHYDRATES | 247 | 154 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | 27 | 19 | All SZGR 2.0 genes in this pathway |
| CORRE MULTIPLE MYELOMA UP | 74 | 45 | All SZGR 2.0 genes in this pathway |
| HATADA METHYLATED IN LUNG CANCER UP | 390 | 236 | All SZGR 2.0 genes in this pathway |
| OKUMURA INFLAMMATORY RESPONSE LPS | 183 | 115 | All SZGR 2.0 genes in this pathway |
| SU LIVER | 55 | 32 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN | 274 | 165 | All SZGR 2.0 genes in this pathway |
| FIRESTEIN PROLIFERATION | 175 | 125 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A12 | 317 | 177 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G12 DN | 15 | 11 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER LATE RECURRENCE DN | 69 | 48 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SURVIVAL DN | 113 | 76 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
| MOOTHA GLYCOGEN METABOLISM | 21 | 16 | All SZGR 2.0 genes in this pathway |