Gene Page: CKAP2

Summary ?
GeneID26586
SymbolCKAP2
SynonymsLB1|TMAP|se20-10
Descriptioncytoskeleton associated protein 2
ReferenceMIM:611569|HGNC:HGNC:1990|Ensembl:ENSG00000136108|HPRD:10832|Vega:OTTHUMG00000016967
Gene typeprotein-coding
Map location13q14
Pascal p-value0.041
Fetal beta-0.499
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DNM:Gulsuner_2013Whole Exome Sequencing analysis155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
CKAP2chr1353035036GCNM_001098525
NM_018204
NM_018204		p.54R>T
.
p.53R>T		missense
splice
missense		SchizophreniaDNM:Gulsuner_2013

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg078980841353029385CKAP22.19E-10-0.0265.94E-7DMG:Jaffe_2016
cg144252571353029355CKAP27.68E-9-0.0133.75E-6DMG:Jaffe_2016
cg112986161353029954CKAP21.69E-8-0.0116.16E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs43695501352744910CKAP2ENSG00000136108.103.582E-60-284654gtex_brain_ba24
rs560337501352747278CKAP2ENSG00000136108.102.716E-70-282286gtex_brain_ba24
rs95358951352765847CKAP2ENSG00000136108.101.27E-60-263717gtex_brain_ba24
rs619572571352769702CKAP2ENSG00000136108.103.918E-70-259862gtex_brain_ba24
rs563042001352781763CKAP2ENSG00000136108.101.19E-70-247801gtex_brain_ba24
rs38665341352786236CKAP2ENSG00000136108.101.39E-70-243328gtex_brain_ba24
rs95359141352791751CKAP2ENSG00000136108.108.174E-80-237813gtex_brain_ba24
rs111482461352797537CKAP2ENSG00000136108.101.393E-70-232027gtex_brain_ba24
rs619573041352798423CKAP2ENSG00000136108.104.417E-80-231141gtex_brain_ba24
rs45457031352802822CKAP2ENSG00000136108.101.351E-70-226742gtex_brain_ba24
rs1381230231352835439CKAP2ENSG00000136108.101.485E-80-194125gtex_brain_ba24
rs95687201352836444CKAP2ENSG00000136108.105.987E-70-193120gtex_brain_ba24
rs774662411352862914CKAP2ENSG00000136108.103.852E-80-166650gtex_brain_ba24
rs95360061352887707CKAP2ENSG00000136108.101.485E-70-141857gtex_brain_ba24
rs65616621352909774CKAP2ENSG00000136108.107.689E-80-119790gtex_brain_ba24
rs65616631352909775CKAP2ENSG00000136108.101.711E-70-119789gtex_brain_ba24
rs2015793811352909775CKAP2ENSG00000136108.101.842E-70-119789gtex_brain_ba24
rs65616641352912099CKAP2ENSG00000136108.102.652E-80-117465gtex_brain_ba24
rs79817321352912217CKAP2ENSG00000136108.108.343E-80-117347gtex_brain_ba24
rs74006021352916665CKAP2ENSG00000136108.101.048E-70-112899gtex_brain_ba24
rs65616661352930045CKAP2ENSG00000136108.103.309E-80-99519gtex_brain_ba24
rs73345831352930352CKAP2ENSG00000136108.103.309E-80-99212gtex_brain_ba24
rs95966491352934610CKAP2ENSG00000136108.103.309E-80-94954gtex_brain_ba24
rs95966511352938582CKAP2ENSG00000136108.109.334E-80-90982gtex_brain_ba24
rs79937481352941631CKAP2ENSG00000136108.102.098E-80-87933gtex_brain_ba24
rs95687281352946593CKAP2ENSG00000136108.101.138E-70-82971gtex_brain_ba24
rs38860771352949053CKAP2ENSG00000136108.101.137E-70-80511gtex_brain_ba24
rs48844521352949784CKAP2ENSG00000136108.101.137E-70-79780gtex_brain_ba24
rs799175171352954465CKAP2ENSG00000136108.101.491E-70-75099gtex_brain_ba24
rs79871151352962097CKAP2ENSG00000136108.101.137E-70-67467gtex_brain_ba24
rs18156691352968645CKAP2ENSG00000136108.101.137E-70-60919gtex_brain_ba24
rs73996311352975580CKAP2ENSG00000136108.102.181E-70-53984gtex_brain_ba24
rs95269131352975837CKAP2ENSG00000136108.101.222E-70-53727gtex_brain_ba24
rs48859531352976491CKAP2ENSG00000136108.101.358E-70-53073gtex_brain_ba24
rs95360661352983981CKAP2ENSG00000136108.101.072E-70-45583gtex_brain_ba24
rs10563351352989863CKAP2ENSG00000136108.102.526E-60-39701gtex_brain_ba24
rs48860181352990717CKAP2ENSG00000136108.101.391E-70-38847gtex_brain_ba24
rs95687321352993412CKAP2ENSG00000136108.102.233E-80-36152gtex_brain_ba24
rs116200621352994026CKAP2ENSG00000136108.109.971E-80-35538gtex_brain_ba24
rs95360691352994756CKAP2ENSG00000136108.102.981E-60-34808gtex_brain_ba24
rs79852621352997161CKAP2ENSG00000136108.101.544E-60-32403gtex_brain_ba24
rs48860771352998697CKAP2ENSG00000136108.102.526E-60-30867gtex_brain_ba24
rs80016241353002995CKAP2ENSG00000136108.102.526E-60-26569gtex_brain_ba24
rs95687341353004222CKAP2ENSG00000136108.102.233E-80-25342gtex_brain_ba24
rs73236661353006058CKAP2ENSG00000136108.102.526E-60-23506gtex_brain_ba24
rs111482521353009048CKAP2ENSG00000136108.101.391E-70-20516gtex_brain_ba24
rs48843541353017474CKAP2ENSG00000136108.102.526E-60-12090gtex_brain_ba24
rs79905811353019433CKAP2ENSG00000136108.102.297E-80-10131gtex_brain_ba24
rs42860071353022518CKAP2ENSG00000136108.108.646E-70-7046gtex_brain_ba24
rs38923371353029485CKAP2ENSG00000136108.102.2E-80-79gtex_brain_ba24
rs95360791353030565CKAP2ENSG00000136108.102.2E-801001gtex_brain_ba24
rs73286531353032735CKAP2ENSG00000136108.102.2E-803171gtex_brain_ba24
rs1395307891353040041CKAP2ENSG00000136108.101.821E-6010477gtex_brain_ba24
rs73219641353040822CKAP2ENSG00000136108.105.087E-8011258gtex_brain_ba24
rs592039041353043727CKAP2ENSG00000136108.101.892E-6014163gtex_brain_ba24
rs116187161353046836CKAP2ENSG00000136108.108.625E-7017272gtex_brain_ba24
rs95269271353051627CKAP2ENSG00000136108.107.393E-7022063gtex_brain_ba24
rs95362361353255012CKAP2ENSG00000136108.103.511E-60225448gtex_brain_ba24
rs95269751353255804CKAP2ENSG00000136108.103.515E-60226240gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007049cell cycleIEA-
GO:0006915apoptosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005874microtubuleIEA-
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HORIUCHI WTAP TARGETS DN 310188All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430232All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228137All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 11662All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS MULTIPLE MYELOMA 1611All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 1 4423All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176111All SZGR 2.0 genes in this pathway
FURUKAWA DUSP6 TARGETS PCI35 DN 7440All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP 16792All SZGR 2.0 genes in this pathway
NAKAYAMA FRA2 TARGETS 4327All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN 200112All SZGR 2.0 genes in this pathway
SHEPARD BMYB TARGETS 7441All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185111All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK DN 2418All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO CURCUMIN SULINDAC 7 1910All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 5334All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245144All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202115All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253147All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315197All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS 11663All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM DN 4031All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346192All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES 14883All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 2 139All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335193All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 182102All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216124All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR 12873All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway