Gene Page: SEC22A
Summary ?
| GeneID | 26984 |
| Symbol | SEC22A |
| Synonyms | SEC22L2 |
| Description | SEC22 homolog A, vesicle trafficking protein |
| Reference | MIM:612442|HGNC:HGNC:20260|HPRD:15313| |
| Gene type | protein-coding |
| Map location | 3q21.1 |
| Pascal p-value | 0.171 |
| Sherlock p-value | 1.814E-4 |
| Fetal beta | 0.981 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Frontal Cortex BA9 Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs113534829 | 3 | 122916578 | SEC22A | ENSG00000121542.7 | 3.419E-6 | 0.05 | -4196 | gtex_brain_ba24 |
| rs67569986 | 3 | 122897935 | SEC22A | ENSG00000121542.7 | 3.086E-6 | 0.01 | -22839 | gtex_brain_putamen_basal |
| rs34922797 | 3 | 122903240 | SEC22A | ENSG00000121542.7 | 1.221E-6 | 0.01 | -17534 | gtex_brain_putamen_basal |
| rs13097154 | 3 | 122909015 | SEC22A | ENSG00000121542.7 | 1.325E-7 | 0.01 | -11759 | gtex_brain_putamen_basal |
| rs12491103 | 3 | 122909397 | SEC22A | ENSG00000121542.7 | 1.508E-7 | 0.01 | -11377 | gtex_brain_putamen_basal |
| rs35255067 | 3 | 122911465 | SEC22A | ENSG00000121542.7 | 1.076E-7 | 0.01 | -9309 | gtex_brain_putamen_basal |
| rs13079069 | 3 | 122913515 | SEC22A | ENSG00000121542.7 | 2.306E-7 | 0.01 | -7259 | gtex_brain_putamen_basal |
| rs34846480 | 3 | 122913552 | SEC22A | ENSG00000121542.7 | 5.132E-8 | 0.01 | -7222 | gtex_brain_putamen_basal |
| rs62261386 | 3 | 122916696 | SEC22A | ENSG00000121542.7 | 1.091E-6 | 0.01 | -4078 | gtex_brain_putamen_basal |
| rs1515370 | 3 | 122922893 | SEC22A | ENSG00000121542.7 | 1.017E-6 | 0.01 | 2119 | gtex_brain_putamen_basal |
| rs62261389 | 3 | 122929861 | SEC22A | ENSG00000121542.7 | 1.017E-6 | 0.01 | 9087 | gtex_brain_putamen_basal |
| rs6764852 | 3 | 122932636 | SEC22A | ENSG00000121542.7 | 1.017E-6 | 0.01 | 11862 | gtex_brain_putamen_basal |
| rs9790285 | 3 | 122938566 | SEC22A | ENSG00000121542.7 | 2.996E-6 | 0.01 | 17792 | gtex_brain_putamen_basal |
| rs62262563 | 3 | 122945361 | SEC22A | ENSG00000121542.7 | 2.996E-6 | 0.01 | 24587 | gtex_brain_putamen_basal |
| rs62262565 | 3 | 122946782 | SEC22A | ENSG00000121542.7 | 1.017E-6 | 0.01 | 26008 | gtex_brain_putamen_basal |
| rs62262566 | 3 | 122948319 | SEC22A | ENSG00000121542.7 | 1.017E-6 | 0.01 | 27545 | gtex_brain_putamen_basal |
| rs6768947 | 3 | 122951073 | SEC22A | ENSG00000121542.7 | 1.017E-6 | 0.01 | 30299 | gtex_brain_putamen_basal |
| rs6800786 | 3 | 122960680 | SEC22A | ENSG00000121542.7 | 2.996E-6 | 0.01 | 39906 | gtex_brain_putamen_basal |
| rs62262568 | 3 | 122962992 | SEC22A | ENSG00000121542.7 | 2.996E-6 | 0.01 | 42218 | gtex_brain_putamen_basal |
| rs57668681 | 3 | 122975604 | SEC22A | ENSG00000121542.7 | 3.815E-6 | 0.01 | 54830 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DAIRKEE TERT TARGETS DN | 124 | 79 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING UP | 108 | 69 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP | 64 | 40 | All SZGR 2.0 genes in this pathway |
| KYNG DNA DAMAGE BY GAMMA RADIATION | 81 | 59 | All SZGR 2.0 genes in this pathway |
| KYNG DNA DAMAGE UP | 226 | 164 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE EARLY LATE | 317 | 190 | All SZGR 2.0 genes in this pathway |
| JUBAN TARGETS OF SPI1 AND FLI1 UP | 115 | 73 | All SZGR 2.0 genes in this pathway |