Gene Page: PABPC1

Summary ?
GeneID26986
SymbolPABPC1
SynonymsPAB1|PABP|PABP1|PABPC2|PABPL1
Descriptionpoly(A) binding protein, cytoplasmic 1
ReferenceMIM:604679|HGNC:HGNC:8554|Ensembl:ENSG00000070756|HPRD:05247|Vega:OTTHUMG00000164779
Gene typeprotein-coding
Map location8q22.2-q23
Pascal p-value0.626
Sherlock p-value0.535
Fetal beta0.849
DMG1 (# studies)
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg059504858101733214PABPC18.95E-9-0.0074.09E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
THADA0.930.93
INTS70.930.93
MCPH10.920.92
DHX150.920.93
RBBP40.920.91
ZNF1430.910.89
XRN20.910.92
KLHL70.910.92
RBMX0.910.90
TEX100.910.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.68-0.86
AF347015.27-0.68-0.83
AF347015.33-0.67-0.85
FXYD1-0.67-0.85
AF347015.31-0.67-0.83
HLA-F-0.67-0.76
C5orf53-0.66-0.72
AF347015.8-0.66-0.85
IFI27-0.65-0.83
MT-CYB-0.65-0.82

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANAPC5APC5anaphase promoting complex subunit 5-HPRD,BioGRID15082755 
BCAR3KIAA0554 | NSP2 | SH2D3Bbreast cancer anti-estrogen resistance 3Affinity Capture-MSBioGRID17353931 
CNOT7CAF1 | hCAF-1CCR4-NOT transcription complex, subunit 7Affinity Capture-Western
Reconstituted Complex		BioGRID18056425 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1Affinity Capture-MSBioGRID17353931 
EIF4A1DDX2A | EIF-4A | EIF4Aeukaryotic translation initiation factor 4A, isoform 1Affinity Capture-WesternBioGRID9548260 
EIF4A2BM-010 | DDX2B | EIF4A | EIF4Feukaryotic translation initiation factor 4A, isoform 2Affinity Capture-MSBioGRID17353931 
EIF4BEIF-4B | PRO1843eukaryotic translation initiation factor 4B-HPRD,BioGRID11274152 
EIF4G1DKFZp686A1451 | EIF4F | EIF4G | p220eukaryotic translation initiation factor 4 gamma, 1-HPRD,BioGRID9857202 
ETF1D5S1995 | ERF | ERF1 | MGC111066 | RF1 | SUP45L1 | TB3-1eukaryotic translation termination factor 1Affinity Capture-WesternBioGRID18056425 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID12388589 
GSPT1551G9.2 | ETF3A | FLJ38048 | FLJ39067 | GST1 | eRF3aG1 to S phase transition 1-HPRD,BioGRID10358005 
GSPT2FLJ10441 | GST2 | eRF3bG1 to S phase transition 2-HPRD,BioGRID10358005 
IKBKEIKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilonAffinity Capture-MSBioGRID17353931 
PAIP1MGC12360poly(A) binding protein interacting protein 1-HPRD,BioGRID9548260 |11997512 
PAIP2MGC72018 | PAIP2Apoly(A) binding protein interacting protein 2-HPRD,BioGRID11438674 
PAN2FLJ39360 | KIAA0710 | USP52 | hPAN2PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)-HPRD,BioGRID14583602 
PAN3-PAN3 polyA specific ribonuclease subunit homolog (S. cerevisiae)Affinity Capture-Western
Reconstituted Complex		BioGRID18056425 
PINX1FLJ20565 | LPTL | LPTS | MGC8850PIN2-interacting protein 1Affinity Capture-MSBioGRID17353931 
PUF60FIR | FLJ31379 | RoBPI | SIAHBP1poly-U binding splicing factor 60KDaAffinity Capture-MSBioGRID17353931 
PXNFLJ16691paxillin-HPRD,BioGRID11704675 
SFRS12DKFZp564B176 | MGC133045 | SRrp508 | SRrp86splicing factor, arginine/serine-rich 12-HPRD14559993 
TOB1APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1transducer of ERBB2, 1Affinity Capture-WesternBioGRID18056425 
UPF1FLJ43809 | FLJ46894 | HUPF1 | KIAA0221 | NORF1 | RENT1 | pNORF1UPF1 regulator of nonsense transcripts homolog (yeast)Affinity Capture-MSBioGRID12723973 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA EIF4 PATHWAY 2419All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION 22275All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 8430All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 17651All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION OF MRNA 2214All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284128All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 4829All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 8450All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 5331All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 17657All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 UP 3827All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN 214133All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178108All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848527All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON 13282All SZGR 2.0 genes in this pathway
PARK HSC VS MULTIPOTENT PROGENITORS UP 1914All SZGR 2.0 genes in this pathway
NADLER OBESITY UP 6134All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX UP 3627All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN 9164All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 12893All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
LEE METASTASIS AND RNA PROCESSING UP 179All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP 13995All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN 10265All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 8956All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335193All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221135All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO NIMUSTINE 1713All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO VINBLASTINE 1812All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE 4533All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289184All SZGR 2.0 genes in this pathway