Summary ?
GeneID27177
SymbolIL36B
SynonymsFIL1|FIL1-(ETA)|FIL1H|FILI-(ETA)|IL-1F8|IL-1H2|IL1-ETA|IL1F8|IL1H2
Descriptioninterleukin 36, beta
ReferenceMIM:605508|HGNC:HGNC:15564|Ensembl:ENSG00000136696|HPRD:05694|Vega:OTTHUMG00000131338
Gene typeprotein-coding
Map location2q14
Pascal p-value0.748
Fetal beta-0.061
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
IL36Bchr2113788640GANM_014438
NM_173178
p.36R>C
p.36R>C
missense
missense
SchizophreniaDNM:Fromer_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs73705640IL1F8271770.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ACD0.940.94
ZNF4460.930.93
C7orf270.930.90
USP210.930.91
TELO20.930.92
MED160.920.91
GTPBP30.920.94
ZNF5740.920.91
PTOV10.920.92
ZNF4080.920.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.73-0.84
AF347015.31-0.71-0.82
MT-CO2-0.71-0.82
AF347015.33-0.70-0.80
AF347015.8-0.70-0.84
MT-CYB-0.69-0.82
AF347015.15-0.67-0.80
C5orf53-0.65-0.69
AF347015.2-0.65-0.80
AF347015.21-0.64-0.85

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005149interleukin-1 receptor bindingNAS10744718 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006955immune responseNAS10744718 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionTAS10744718 
GO:0005615extracellular spaceIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 5334All SZGR 2.0 genes in this pathway
MATTHEWS SKIN CARCINOGENESIS VIA JUN 1710All SZGR 2.0 genes in this pathway
GENTLES LEUKEMIC STEM CELL DN 1910All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway