Gene Page: VPS4A
Summary ?
| GeneID | 27183 |
| Symbol | VPS4A |
| Synonyms | SKD1|SKD1A|SKD2|VPS4|VPS4-1 |
| Description | vacuolar protein sorting 4 homolog A (S. cerevisiae) |
| Reference | MIM:609982|HGNC:HGNC:13488|HPRD:11676| |
| Gene type | protein-coding |
| Map location | 16q22.1 |
| Pascal p-value | 0.001 |
| Sherlock p-value | 0.996 |
| eGene | Caudate basal ganglia Hypothalamus Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KCNA6 | 0.88 | 0.91 |
| FBXO31 | 0.87 | 0.92 |
| BAHD1 | 0.86 | 0.90 |
| ADO | 0.86 | 0.90 |
| MKL1 | 0.85 | 0.90 |
| INPP4A | 0.85 | 0.88 |
| CEP68 | 0.85 | 0.89 |
| TMEM127 | 0.85 | 0.88 |
| KIF3C | 0.85 | 0.89 |
| ATCAY | 0.84 | 0.88 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BDH2 | -0.64 | -0.69 |
| SERPINB6 | -0.64 | -0.69 |
| AP002478.3 | -0.64 | -0.75 |
| FXYD1 | -0.63 | -0.69 |
| AF347015.31 | -0.63 | -0.71 |
| MT-CO2 | -0.63 | -0.72 |
| S100B | -0.63 | -0.70 |
| AF347015.33 | -0.62 | -0.68 |
| AL139819.3 | -0.62 | -0.70 |
| HIGD1B | -0.61 | -0.70 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ENDOCYTOSIS | 183 | 132 | All SZGR 2.0 genes in this pathway |
| PID CXCR4 PATHWAY | 102 | 78 | All SZGR 2.0 genes in this pathway |
| REACTOME MEMBRANE TRAFFICKING | 129 | 74 | All SZGR 2.0 genes in this pathway |
| REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | 27 | 15 | All SZGR 2.0 genes in this pathway |
| PROVENZANI METASTASIS UP | 194 | 112 | All SZGR 2.0 genes in this pathway |
| MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING UP | 108 | 69 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| STEARMAN LUNG CANCER EARLY VS LATE UP | 125 | 89 | All SZGR 2.0 genes in this pathway |
| CHNG MULTIPLE MYELOMA HYPERPLOID DN | 28 | 19 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |