SZGR2

Summary ?

GeneID	27185
Symbol	DISC1
Synonyms	C1orf136\|SCZD9
Description	disrupted in schizophrenia 1
Reference	MIM:605210\|HGNC:HGNC:2888\|Ensembl:ENSG00000162946\|HPRD:05553\|Vega:OTTHUMG00000037835
Gene type	protein-coding
Map location	1q42.1
Sherlock p-value	0.155
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	3	Link to SZGene
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 32.3086

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg16366945	1	231970657	DISC1;TSNAX-DISC1	2.808E-4	0.238	0.039	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs1521516	chr12	51055707	DISC1	27185		0.18		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		12812986 \|15094396 \|17043677
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008150	biological_process	ND		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005813	centrosome	IEA		-
GO:0005856	cytoskeleton	IEA		-
GO:0005874	microtubule	IEA		-
GO:0005575	cellular_component	ND		-
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTN2	CMD1AA	actinin, alpha 2	DISC-1 interacts with alpha-actinin 2.	BIND	12812986
ACTN2	CMD1AA	actinin, alpha 2	-	HPRD,BioGRID	12812986
ANKHD1	MASK \| VBARP	ankyrin repeat and KH domain containing 1	DISC-1 interacts with APAP2.	BIND	12812986
ATF4	CREB-2 \| CREB2 \| TAXREB67 \| TXREB	activating transcription factor 4 (tax-responsive enhancer element B67)	-	HPRD,BioGRID	12812986
ATF4	CREB-2 \| CREB2 \| TAXREB67 \| TXREB	activating transcription factor 4 (tax-responsive enhancer element B67)	An unspecified isoform of DISC1 interacts with ATF4.	BIND	14623284
ATF4	CREB-2 \| CREB2 \| TAXREB67 \| TXREB	activating transcription factor 4 (tax-responsive enhancer element B67)	DISC-1 interacts with ATF4.	BIND	12812986
ATF5	ATFX \| FLJ34666 \| HMFN0395	activating transcription factor 5	-	HPRD,BioGRID	12812986
ATF5	ATFX \| FLJ34666 \| HMFN0395	activating transcription factor 5	DISC-1 interacts with ATF5.	BIND	12812986
ATF7IP	FLJ10139 \| FLJ10688 \| MCAF \| p621	activating transcription factor 7 interacting protein	DISC-1 interacts with ATF7ip.	BIND	12812986
ATF7IP	FLJ10139 \| FLJ10688 \| MCAF \| p621	activating transcription factor 7 interacting protein	Two-hybrid	BioGRID	12812986
CCDC141	FLJ26337 \| FLJ39502 \| MGC134803	coiled-coil domain containing 141	Two-hybrid	BioGRID	12812986
CEP290	3H11Ag \| BBS14 \| FLJ13615 \| FLJ21979 \| JBTS5 \| JBTS6 \| KIAA0373 \| LCA10 \| MKS4 \| NPHP6 \| SLSN6 \| rd16	centrosomal protein 290kDa	An unspecified isoform of DISC1 interacts with KIAA0373.	BIND	14623284
CEP63	FLJ13386 \| MGC78416	centrosomal protein 63kDa	Affinity Capture-Western Two-hybrid	BioGRID	12812986
CIT	CRIK \| KIAA0949 \| STK21	citron (rho-interacting, serine/threonine kinase 21)	Two-hybrid	BioGRID	12506198
COL4A1	arresten	collagen, type IV, alpha 1	Two-hybrid	BioGRID	12812986
EIF3A	EIF3 \| EIF3S10 \| KIAA0139 \| P167 \| TIF32 \| eIF3-p170 \| eIF3-theta \| p180 \| p185	eukaryotic translation initiation factor 3, subunit A	Affinity Capture-Western Two-hybrid	BioGRID	12812986
EIF3H	EIF3S3 \| MGC102958 \| eIF3-gamma \| eIF3-p40	eukaryotic translation initiation factor 3, subunit H	DISC-1 interacts with EIF3.	BIND	12812986
EIF3H	EIF3S3 \| MGC102958 \| eIF3-gamma \| eIF3-p40	eukaryotic translation initiation factor 3, subunit H	Two-hybrid	BioGRID	12812986
EPB49	DMT \| FLJ78462 \| FLJ98848	erythrocyte membrane protein band 4.9 (dematin)	An unspecified isoform of DISC1 interacts with DMT.	BIND	14623284
FEZ1	-	fasciculation and elongation protein zeta 1 (zygin I)	-	HPRD,BioGRID	12874605
GOLGA2	GM130 \| MGC20672	golgi autoantigen, golgin subfamily a, 2	An unspecified isoform of DISC1 interacts with GM130.	BIND	14623284
IMMT	DKFZp779P1653 \| HMP \| MGC111146 \| P87 \| P87/89 \| P89 \| PIG4 \| PIG52	inner membrane protein, mitochondrial (mitofilin)	An unspecified isoform of DISC1 interacts with IMMT.	BIND	14623284
ITSN1	ITSN \| MGC134948 \| MGC134949 \| SH3D1A \| SH3P17	intersectin 1 (SH3 domain protein)	DISC-1 interacts with ITSN.	BIND	12812986
ITSN1	ITSN \| MGC134948 \| MGC134949 \| SH3D1A \| SH3P17	intersectin 1 (SH3 domain protein)	Two-hybrid	BioGRID	12812986
KALRN	DUET \| FLJ16443 \| HAPIP \| TRAD \| duo	kalirin, RhoGEF kinase	An unspecified isoform of DISC1 interacts with HAPIP.	BIND	14623284
KATNAL1	MGC2599	katanin p60 subunit A-like 1	An unspecified isoform of DISC1 interacts with MGC2599.	BIND	14623284
KCNQ5	Kv7.5	potassium voltage-gated channel, KQT-like subfamily, member 5	Two-hybrid	BioGRID	12506198
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	12812986
MAP1A	FLJ77111 \| MAP1L \| MTAP1A	microtubule-associated protein 1A	-	HPRD,BioGRID	12812986
MAP1A	FLJ77111 \| MAP1L \| MTAP1A	microtubule-associated protein 1A	DISC-1 interacts with MAP1A.	BIND	12812986
MGAT3	FLJ43371 \| GNT-III \| GNT3 \| MGC141943 \| MGC142278	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	An unspecified isoform of DISC1 interacts with MGAT3.	BIND	14623284
MYO1A	BBMI \| DFNA48 \| MIHC \| MYHL	myosin IA	Two-hybrid	BioGRID	12812986
NDE1	FLJ20101 \| HOM-TES-87 \| NUDE \| NUDE1	nudE nuclear distribution gene E homolog 1 (A. nidulans)	An unspecified isoform of DISC1 interacts with NUDE.	BIND	14623284
NDEL1	DKFZp451M0318 \| EOPA \| MITAP1 \| NUDEL	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	-	HPRD,BioGRID	12506198
NDEL1	DKFZp451M0318 \| EOPA \| MITAP1 \| NUDEL	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	DISC-1 interacts with NUDEL.	BIND	12812986
PCNT	KEN \| MOPD2 \| PCN \| PCNT2 \| PCNTB \| PCTN2 \| SCKL4	pericentrin	DISC1 interacts with kendrin.	BIND	15094396
PPFIA4	-	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	An unspecified isoform of DISC1 interacts with PPFIA4.	BIND	14623284
RANBP9	RANBPM	RAN binding protein 9	-	HPRD,BioGRID	12812986
RANBP9	RANBPM	RAN binding protein 9	DISC-1 interacts with RanBPM.	BIND	12812986
RASSF7	C11orf13 \| HRAS1 \| HRC1 \| MGC126069 \| MGC126070	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7	Two-hybrid	BioGRID	12812986
SMARCE1	BAF57	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	An unspecified isoform of DISC1 interacts with SMARCE1.	BIND	14623284
SPTAN1	(ALPHA)II-SPECTRIN \| FLJ44613 \| NEAS	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	An unspecified isoform of DISC1 interacts with SPTAN1.	BIND	14623284
SPTBN4	KIAA1642 \| QV \| SPNB4 \| SPTBN3	spectrin, beta, non-erythrocytic 4	-	HPRD,BioGRID	12506198 \|12812986
SPTBN4	KIAA1642 \| QV \| SPNB4 \| SPTBN3	spectrin, beta, non-erythrocytic 4	DISC-1 interacts with B4 Spectrin.	BIND	12812986
SYNE1	8B \| CPG2 \| DKFZp781J13156 \| FLJ30878 \| FLJ41140 \| KIAA0796 \| KIAA1262 \| KIAA1756 \| MYNE1 \| SCAR8	spectrin repeat containing, nuclear envelope 1	-	HPRD,BioGRID	12812986
TRAF3IP1	DKFZp434F124 \| MIP-T3 \| MIPT3	TNF receptor-associated factor 3 interacting protein 1	DISC-1 interacts with MIP-T3.	BIND	12812986
TRAF3IP1	DKFZp434F124 \| MIP-T3 \| MIPT3	TNF receptor-associated factor 3 interacting protein 1	Affinity Capture-Western Two-hybrid	BioGRID	12812986
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	-	HPRD,BioGRID	12506198

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
DOANE RESPONSE TO ANDROGEN UP	184	125	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN	104	59	All SZGR 2.0 genes in this pathway
AMUNDSON GENOTOXIC SIGNATURE	105	68	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
YOSHIOKA LIVER CANCER EARLY RECURRENCE DN	65	31	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN	418	245	All SZGR 2.0 genes in this pathway

Gene Page: DISC1