Gene Page: AMPD3

Summary ?
GeneID272
SymbolAMPD3
Synonyms-
Descriptionadenosine monophosphate deaminase 3
ReferenceMIM:102772|HGNC:HGNC:470|Ensembl:ENSG00000133805|HPRD:00041|Vega:OTTHUMG00000165682
Gene typeprotein-coding
Map location11p15
Pascal p-value0.661
Sherlock p-value0.085
Fetal beta-2.086
DMG1 (# studies)
eGeneCaudate basal ganglia
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg264894131110476976AMPD34.81E-6-0.5980.01DMG:Wockner_2014
cg073292511110476662AMPD36.03E-5-0.5860.023DMG:Wockner_2014
cg191324621110476608AMPD31.019E-4-0.5850.028DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs11042789chr1110434408AMPD32720.17cis
rs99715621110464659AMPD3ENSG00000133805.113.93E-80134799gtex_brain_putamen_basal
rs3980757161110466453AMPD3ENSG00000133805.111.836E-80136593gtex_brain_putamen_basal
rs116052321110468501AMPD3ENSG00000133805.117.128E-70138641gtex_brain_putamen_basal
rs116047801110468671AMPD3ENSG00000133805.115.752E-80138811gtex_brain_putamen_basal
rs116067031110468712AMPD3ENSG00000133805.113.013E-70138852gtex_brain_putamen_basal
rs116026321110468724AMPD3ENSG00000133805.115.994E-80138864gtex_brain_putamen_basal
rs116048331110468906AMPD3ENSG00000133805.115.987E-80139046gtex_brain_putamen_basal
rs116048381110468953AMPD3ENSG00000133805.115.985E-80139093gtex_brain_putamen_basal
rs79299991110470440AMPD3ENSG00000133805.113.003E-70140580gtex_brain_putamen_basal
rs64842901110470852AMPD3ENSG00000133805.112.975E-70140992gtex_brain_putamen_basal
rs71123211110471218AMPD3ENSG00000133805.112.967E-70141358gtex_brain_putamen_basal
rs71119701110471680AMPD3ENSG00000133805.111.143E-70141820gtex_brain_putamen_basal
rs110428111110473889AMPD3ENSG00000133805.111.494E-70144029gtex_brain_putamen_basal
rs110428121110474010AMPD3ENSG00000133805.111.419E-90144150gtex_brain_putamen_basal
rs2009021091110474496AMPD3ENSG00000133805.113.765E-70144636gtex_brain_putamen_basal
rs612643981110474497AMPD3ENSG00000133805.115.73E-90144637gtex_brain_putamen_basal
rs20710201110478228AMPD3ENSG00000133805.112.771E-70148368gtex_brain_putamen_basal
rs9365141110481613AMPD3ENSG00000133805.113.651E-90151753gtex_brain_putamen_basal
rs9365131110481667AMPD3ENSG00000133805.113.7E-90151807gtex_brain_putamen_basal
rs108404201110490415AMPD3ENSG00000133805.113.788E-90160555gtex_brain_putamen_basal
rs108404221110491741AMPD3ENSG00000133805.111.849E-60161881gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ACADVL0.770.79
TTC7A0.700.68
MYO15B0.690.66
SLC27A10.680.70
PILRB0.670.64
LAT0.670.61
MYO15B0.670.66
PLD20.670.73
COL11A20.660.66
AC010618.20.650.66
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GUCY1A2-0.42-0.42
PPM1L-0.39-0.33
LIN7A-0.39-0.39
MAPK6-0.38-0.36
LASS6-0.38-0.34
HSPA13-0.37-0.37
MOBKL3-0.37-0.40
LMBRD2-0.37-0.39
DOK6-0.37-0.36
ZYG11B-0.37-0.33

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PURINE METABOLISM 15996All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF NUCLEOTIDES 7245All SZGR 2.0 genes in this pathway
REACTOME PURINE SALVAGE 1311All SZGR 2.0 genes in this pathway
REACTOME PURINE METABOLISM 3324All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS UP 5238All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN 14383All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS F DN 3324All SZGR 2.0 genes in this pathway
XU HGF TARGETS INDUCED BY AKT1 48HR UP 148All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261155All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
KIM GERMINAL CENTER T HELPER UP 6642All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182116All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 12890All SZGR 2.0 genes in this pathway
MARCINIAK ER STRESS RESPONSE VIA CHOP 2517All SZGR 2.0 genes in this pathway
KIM HYPOXIA 2521All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293160All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY DN 14588All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388234All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285167All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL DN 12775All SZGR 2.0 genes in this pathway
ZHAN V1 LATE DIFFERENTIATION GENES UP 3225All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K4ME3 12868All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP 6748All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MIKKELSEN NPC LCP WITH H3K4ME3 5834All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 6850All SZGR 2.0 genes in this pathway
HO LIVER CANCER VASCULAR INVASION 136All SZGR 2.0 genes in this pathway
NIELSEN GIST VS SYNOVIAL SARCOMA DN 2017All SZGR 2.0 genes in this pathway
NIELSEN GIST 9866All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216130All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway
QI HYPOXIA 14096All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242146All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 11674All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211119All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP 162103All SZGR 2.0 genes in this pathway