Gene Page: MCAT
Summary ?
| GeneID | 27349 |
| Symbol | MCAT |
| Synonyms | FASN2C|MCT|MT|NET62|fabD |
| Description | malonyl-CoA-acyl carrier protein transacylase |
| Reference | MIM:614479|HGNC:HGNC:29622|Ensembl:ENSG00000100294|HPRD:14786|Vega:OTTHUMG00000150704 |
| Gene type | protein-coding |
| Map location | 22q13.31 |
| Pascal p-value | 0.046 |
| Sherlock p-value | 0.451 |
| eGene | Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10929332 | chr2 | 234938081 | MCAT | 27349 | 0.13 | trans | ||
| rs2878 | chr7 | 102953620 | MCAT | 27349 | 0.16 | trans | ||
| rs6003067 | 22 | 43522427 | MCAT | ENSG00000100294.8 | 1.721E-6 | 0.03 | 16973 | gtex_brain_putamen_basal |
| rs2235316 | 22 | 43523991 | MCAT | ENSG00000100294.8 | 7.034E-7 | 0.03 | 15409 | gtex_brain_putamen_basal |
| rs2235317 | 22 | 43524000 | MCAT | ENSG00000100294.8 | 7.034E-7 | 0.03 | 15400 | gtex_brain_putamen_basal |
| rs4988438 | 22 | 43524487 | MCAT | ENSG00000100294.8 | 7.186E-7 | 0.03 | 14913 | gtex_brain_putamen_basal |
| rs5759176 | 22 | 43526496 | MCAT | ENSG00000100294.8 | 1.751E-6 | 0.03 | 12904 | gtex_brain_putamen_basal |
| rs5759177 | 22 | 43526704 | MCAT | ENSG00000100294.8 | 6.517E-7 | 0.03 | 12696 | gtex_brain_putamen_basal |
| rs2245947 | 22 | 43528251 | MCAT | ENSG00000100294.8 | 1.766E-6 | 0.03 | 11149 | gtex_brain_putamen_basal |
| rs737802 | 22 | 43528793 | MCAT | ENSG00000100294.8 | 1.74E-6 | 0.03 | 10607 | gtex_brain_putamen_basal |
| rs7402 | 22 | 43529029 | MCAT | ENSG00000100294.8 | 1.73E-6 | 0.03 | 10371 | gtex_brain_putamen_basal |
| rs2066910 | 22 | 43529517 | MCAT | ENSG00000100294.8 | 1.725E-6 | 0.03 | 9883 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| VANHARANTA UTERINE FIBROID WITH 7Q DELETION DN | 36 | 23 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| WONG MITOCHONDRIA GENE MODULE | 217 | 122 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | All SZGR 2.0 genes in this pathway |