Gene Page: GLI1
Summary ?
| GeneID | 2735 |
| Symbol | GLI1 |
| Synonyms | GLI |
| Description | GLI family zinc finger 1 |
| Reference | MIM:165220|HGNC:HGNC:4317|Ensembl:ENSG00000111087|HPRD:01311|Vega:OTTHUMG00000167332 |
| Gene type | protein-coding |
| Map location | 12q13.3 |
| Pascal p-value | 0.024 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MERTK | 0.91 | 0.87 |
| ACSBG1 | 0.90 | 0.91 |
| DIO2 | 0.89 | 0.85 |
| SLC13A5 | 0.89 | 0.83 |
| PLEKHO2 | 0.88 | 0.72 |
| HEPH | 0.88 | 0.82 |
| PPP1R3C | 0.88 | 0.84 |
| ALDH4A1 | 0.87 | 0.89 |
| GPR37L1 | 0.87 | 0.88 |
| SLC1A3 | 0.86 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MED19 | -0.60 | -0.71 |
| DUSP12 | -0.58 | -0.71 |
| CWF19L1 | -0.57 | -0.65 |
| TAF11 | -0.57 | -0.66 |
| RTF1 | -0.57 | -0.70 |
| PAK1IP1 | -0.57 | -0.68 |
| PHF14 | -0.56 | -0.71 |
| ZNF329 | -0.56 | -0.64 |
| MLLT11 | -0.56 | -0.63 |
| NOP56 | -0.56 | -0.63 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG HEDGEHOG SIGNALING PATHWAY | 56 | 42 | All SZGR 2.0 genes in this pathway |
| KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG BASAL CELL CARCINOMA | 55 | 44 | All SZGR 2.0 genes in this pathway |
| BIOCARTA SHH PATHWAY | 16 | 15 | All SZGR 2.0 genes in this pathway |
| PID HEDGEHOG GLI PATHWAY | 48 | 35 | All SZGR 2.0 genes in this pathway |
| HUMMERICH SKIN CANCER PROGRESSION DN | 100 | 64 | All SZGR 2.0 genes in this pathway |
| INGRAM SHH TARGETS UP | 127 | 79 | All SZGR 2.0 genes in this pathway |
| LEE TARGETS OF PTCH1 AND SUFU UP | 53 | 37 | All SZGR 2.0 genes in this pathway |
| POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC DN | 59 | 35 | All SZGR 2.0 genes in this pathway |
| YAMAZAKI TCEB3 TARGETS DN | 215 | 132 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 | 103 | 68 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE G2 M | 216 | 124 | All SZGR 2.0 genes in this pathway |
| PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP | 134 | 85 | All SZGR 2.0 genes in this pathway |
| MADAN DPPA4 TARGETS | 46 | 26 | All SZGR 2.0 genes in this pathway |
| DELACROIX RAR BOUND ES | 462 | 273 | All SZGR 2.0 genes in this pathway |