SZGR2

Summary ?

GeneID	2747
Symbol	GLUD2
Synonyms	GDH2\|GLUDP1
Description	glutamate dehydrogenase 2
Reference	MIM:300144\|HGNC:HGNC:4336\|Ensembl:ENSG00000182890\|HPRD:02143\|Vega:OTTHUMG00000022320
Gene type	protein-coding
Map location	Xq24-q25
Sherlock p-value	0.329
Fetal beta	-0.706
Support	Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TRUB1	0.90	0.93
MTMR6	0.90	0.92
UHRF1BP1L	0.90	0.91
NCKAP1	0.89	0.91
TSNAX	0.88	0.90
UBE2W	0.88	0.91
RPRD1A	0.87	0.91
PPP1R2	0.87	0.90
PRKACB	0.87	0.89
RFK	0.87	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AL022328.1	-0.53	-0.64
C16orf79	-0.50	-0.55
EIF4EBP3	-0.48	-0.55
MICALL2	-0.47	-0.53
GSDMD	-0.46	-0.52
AC098691.2	-0.45	-0.48
RAB34	-0.45	-0.53
ACP6	-0.44	-0.49
AC069281.3	-0.44	-0.54
GPT	-0.44	-0.49

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	IEA	glutamate (GO term level: 6)	-
GO:0004352	glutamate dehydrogenase activity	IDA	glutamate (GO term level: 6)	8207021 \|15578726
GO:0005488	binding	IEA		-
GO:0016491	oxidoreductase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006536	glutamate metabolic process	IDA	glutamate (GO term level: 8)	8207021
GO:0006520	amino acid metabolic process	IEA		-
GO:0055114	oxidation reduction	IDA		8207021
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005739	mitochondrion	IEA		-
GO:0005759	mitochondrial matrix	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM	32	26	All SZGR 2.0 genes in this pathway
KEGG ARGININE AND PROLINE METABOLISM	54	39	All SZGR 2.0 genes in this pathway
KEGG NITROGEN METABOLISM	23	16	All SZGR 2.0 genes in this pathway
KEGG PROXIMAL TUBULE BICARBONATE RECLAMATION	23	16	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST NORMAL DUCTAL VS LOBULAR UP	68	40	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP	341	197	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN	146	94	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP	182	119	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN	261	183	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002	429	260	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN	193	112	All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN	80	54	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	547	553	m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	547	553	m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-15/16/195/424/497	548	554	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GLUD2