SZGR2

Summary ?

GeneID	2775
Symbol	GNAO1
Synonyms	EIEE17\|G-ALPHA-o\|GNAO
Description	G protein subunit alpha o1
Reference	MIM:139311\|HGNC:HGNC:4389\|Ensembl:ENSG00000087258\|HPRD:00757\|Vega:OTTHUMG00000133241
Gene type	protein-coding
Map location	16q13
Pascal p-value	0.224
Sherlock p-value	0.003
TADA p-value	0.011
Fetal beta	-0.889
DMG	1 (# studies)
eGene	Myers' cis & trans
Support	G-PROTEIN RELAY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin G2Cdb.human_mGluR5 G2Cdb.human_Synaptosome G2Cdb.human_TAP-PSD-95-CORE G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	1
DNM:Xu_2012	Whole Exome Sequencing analysis	De novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	1	Link to SZGene
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.4488

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
GNAO1	chr16	56370728	G	A	NM_020988 NM_138736	p.227A>T p.227A>T	missense missense			Schizophrenia	DNM:Xu_2012

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg13936125	16	56225599	GNAO1		-0.023	0.25	DMG:Nishioka_2013

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs17029291	chr3	32402138	GNAO1	2775		0.02		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0004871	signal transducer activity	IEA		-
GO:0003924	GTPase activity	TAS		1899283
GO:0005525	GTP binding	IEA		-
GO:0019001	guanyl nucleotide binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007212	dopamine receptor signaling pathway	IEA	dopamine (GO term level: 8)	-
GO:0009987	cellular process	IEA		-
GO:0007165	signal transduction	IEA		-
GO:0008016	regulation of heart contraction	IEA		-
GO:0007626	locomotory behavior	IEA		-
GO:0006936	muscle contraction	TAS		9050846
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADORA1	RDC7	adenosine A1 receptor	-	HPRD	10521440
ADRA2A	ADRA2 \| ADRA2R \| ADRAR \| ALPHA2AAR \| ZNF32	adrenergic, alpha-2A-, receptor	-	HPRD	7887906 \|11732925
ADRA2C	ADRA2L2 \| ADRA2RL2 \| ADRARL2 \| ALPHA2CAR	adrenergic, alpha-2C-, receptor	-	HPRD	1349607
CACNA1B	BIII \| CACNL1A5 \| CACNN \| Cav2.2	calcium channel, voltage-dependent, N type, alpha 1B subunit	Reconstituted Complex	BioGRID	11395521
CRHR1	CRF-R \| CRF1 \| CRFR1 \| CRH-R1h \| CRHR \| CRHR1f	corticotropin releasing hormone receptor 1	-	HPRD,BioGRID	10598591
DCTN2	DCTN50 \| DYNAMITIN \| RBP50	dynactin 2 (p50)	Two-hybrid	BioGRID	16169070
FFAR2	FFA2R \| GPR43	free fatty acid receptor 2	-	HPRD	12711604
GPSM2	LGN \| Pins	G-protein signaling modulator 2 (AGS3-like, C. elegans)	-	HPRD	12925752
HRH4	AXOR35 \| BG26 \| GPCR105 \| GPRv53 \| H4 \| H4R \| HH4R \| MGC133027	histamine receptor H4	-	HPRD	10973974
HTR1F	5-HT1F \| 5HT6 \| HTR1EL \| MR77	5-hydroxytryptamine (serotonin) receptor 1F	-	HPRD	11916537
NGB	-	neuroglobin	Reconstituted Complex	BioGRID	12860983
OPRD1	OPRD	opioid receptor, delta 1	-	HPRD,BioGRID	8393523
OPRM1	KIAA0403 \| MOR \| MOR1 \| OPRM	opioid receptor, mu 1	-	HPRD,BioGRID	8393523
PTPRU	FLJ37530 \| FMI \| GLEPP1 \| PCP-2 \| PTP \| PTP-J \| PTP-PI \| PTPPSI \| PTPRO \| PTPU2 \| R-PTP-PSI \| hPTP-J	protein tyrosine phosphatase, receptor type, U	-	HPRD	10196137
RGS14	-	regulator of G-protein signaling 14	-	HPRD	10926822
RGS16	A28-RGS14 \| A28-RGS14P \| RGS-R	regulator of G-protein signaling 16	Reconstituted Complex	BioGRID	9079700
RGS19	GAIP \| RGSGAIP	regulator of G-protein signaling 19	-	HPRD,BioGRID	8986788
RGS4	DKFZp761F1924 \| MGC2124 \| MGC60244 \| RGP4 \| SCZD9	regulator of G-protein signaling 4	-	HPRD,BioGRID	9660808
RGS5	MST092 \| MST106 \| MST129 \| MSTP032 \| MSTP092 \| MSTP106 \| MSTP129	regulator of G-protein signaling 5	-	HPRD,BioGRID	9079700
RGS7	-	regulator of G-protein signaling 7	-	HPRD,BioGRID	9572280
RIC8A	MGC104517 \| MGC131931 \| MGC148073 \| MGC148074 \| RIC8 \| synembryn	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	-	HPRD,BioGRID	12509430
S1PR5	EDG8 \| Edg-8 \| S1P5 \| SPPR-1 \| SPPR-2	sphingosine-1-phosphate receptor 5	-	HPRD	11069896
SCN8A	CerIII \| MED \| NaCh6 \| Nav1.6 \| PN4	sodium channel, voltage gated, type VIII, alpha subunit	-	HPRD,BioGRID	10066808

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG LONG TERM DEPRESSION	70	53	All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS	102	80	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY	29	24	All SZGR 2.0 genes in this pathway
PID S1P S1P4 PATHWAY	14	11	All SZGR 2.0 genes in this pathway
PID S1P S1P1 PATHWAY	21	18	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID S1P META PATHWAY	21	14	All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY	31	27	All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY	48	35	All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY	43	34	All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY	43	32	All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM	120	84	All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING	78	56	All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS	43	32	All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN ACTIVATION	27	15	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION	93	65	All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	25	15	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN	367	220	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
ROYLANCE BREAST CANCER 16Q COPY NUMBER DN	26	19	All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP	142	96	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN	165	107	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN	180	110	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN	181	107	All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP	207	128	All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER DN	54	37	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH VS LOW DN	32	21	All SZGR 2.0 genes in this pathway
WATTEL AUTONOMOUS THYROID ADENOMA UP	73	47	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION DN	44	30	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
MCCLUNG DELTA FOSB TARGETS 8WK	47	38	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP	250	168	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2	86	50	All SZGR 2.0 genes in this pathway
KAMMINGA SENESCENCE	41	26	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN	308	187	All SZGR 2.0 genes in this pathway
DURAND STROMA S UP	297	194	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	934	940	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	934	940	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-129-5p	993	999	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	993	999	1A	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-134	1142	1149	1A,m8	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-139	175	181	1A	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-139	175	181	1A	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-181	1013	1019	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-203.1	1152	1158	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-218	569	575	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-30-5p	1021	1028	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-326	138	144	m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-330	244	250	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-539	234	241	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GNAO1