Gene Page: GNG3
Summary ?
| GeneID | 2785 |
| Symbol | GNG3 |
| Synonyms | - |
| Description | G protein subunit gamma 3 |
| Reference | MIM:608941|HGNC:HGNC:4405|Ensembl:ENSG00000162188|HPRD:12337|Vega:OTTHUMG00000167560 |
| Gene type | protein-coding |
| Map location | 11p11 |
| Pascal p-value | 0.735 |
| Sherlock p-value | 0.423 |
| DEG p-value | DEG:Maycox_2009:CC_BA10_fold_change=-1.12:CC_BA10_disease_P=0.0475:HBB_BA9_fold_change=-1.30:HBB_BA9_disease_P=0.0372 |
| Fetal beta | -1.465 |
| Support | CANABINOID DOPAMINE G-PROTEIN RELAY METABOTROPIC GLUTAMATE RECEPTOR SEROTONIN |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DEG:Maycox_2009 | Microarray to determine the expression of over 30000 mRNA transcripts in post-mortem tissue | We included 51 genes whose expression changes are common between two schizophrenia cohorts. | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg24755189 | 11 | 62475373 | BSCL2;GNG3 | 5.747E-4 | 0.472 | 0.049 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ANKRD11 | 0.94 | 0.95 |
| HERC2 | 0.92 | 0.92 |
| MTHFR | 0.91 | 0.92 |
| PCNT | 0.91 | 0.93 |
| ZNF592 | 0.91 | 0.93 |
| MLL2 | 0.90 | 0.92 |
| TXLNA | 0.90 | 0.93 |
| UBN1 | 0.90 | 0.91 |
| KSR1 | 0.90 | 0.91 |
| TNRC6C | 0.89 | 0.92 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.66 | -0.73 |
| C1orf54 | -0.66 | -0.78 |
| AF347015.31 | -0.66 | -0.67 |
| GNG11 | -0.64 | -0.71 |
| HIGD1B | -0.63 | -0.66 |
| VAMP5 | -0.62 | -0.67 |
| MT-CO2 | -0.62 | -0.64 |
| AF347015.27 | -0.61 | -0.62 |
| GMFG | -0.60 | -0.67 |
| RHOC | -0.60 | -0.63 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | All SZGR 2.0 genes in this pathway |
| KEGG TASTE TRANSDUCTION | 52 | 28 | All SZGR 2.0 genes in this pathway |
| REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | 205 | 136 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 186 | 155 | All SZGR 2.0 genes in this pathway |
| REACTOME NEURONAL SYSTEM | 279 | 221 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME INTEGRATION OF ENERGY METABOLISM | 120 | 84 | All SZGR 2.0 genes in this pathway |
| REACTOME OPIOID SIGNALLING | 78 | 56 | All SZGR 2.0 genes in this pathway |
| REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 137 | 110 | All SZGR 2.0 genes in this pathway |
| REACTOME G PROTEIN ACTIVATION | 27 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION | 34 | 23 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | 43 | 28 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA Q SIGNALLING EVENTS | 184 | 116 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF INSULIN SECRETION | 93 | 65 | All SZGR 2.0 genes in this pathway |
| REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | 25 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | 88 | 58 | All SZGR 2.0 genes in this pathway |
| REACTOME GLUCAGON TYPE LIGAND RECEPTORS | 33 | 22 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA1213 SIGNALLING EVENTS | 74 | 56 | All SZGR 2.0 genes in this pathway |
| REACTOME ADP SIGNALLING THROUGH P2RY1 | 25 | 16 | All SZGR 2.0 genes in this pathway |
| REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | 20 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA I SIGNALLING EVENTS | 195 | 114 | All SZGR 2.0 genes in this pathway |
| REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | 25 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA S SIGNALLING EVENTS | 121 | 82 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA Z SIGNALLING EVENTS | 44 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME G PROTEIN BETA GAMMA SIGNALLING | 28 | 18 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNAL AMPLIFICATION | 31 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 23 | 14 | All SZGR 2.0 genes in this pathway |
| REACTOME ADP SIGNALLING THROUGH P2RY12 | 21 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | 31 | 23 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | 32 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME PLATELET HOMEOSTASIS | 78 | 49 | All SZGR 2.0 genes in this pathway |
| REACTOME AQUAPORIN MEDIATED TRANSPORT | 51 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | 19 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | 44 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | 25 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME GABA B RECEPTOR ACTIVATION | 38 | 26 | All SZGR 2.0 genes in this pathway |
| REACTOME GABA RECEPTOR ACTIVATION | 52 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| REACTOME POTASSIUM CHANNELS | 98 | 68 | All SZGR 2.0 genes in this pathway |
| REACTOME INWARDLY RECTIFYING K CHANNELS | 31 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | 208 | 138 | All SZGR 2.0 genes in this pathway |
| GUO HEX TARGETS UP | 81 | 54 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| PASINI SUZ12 TARGETS DN | 315 | 215 | All SZGR 2.0 genes in this pathway |