Gene Page: GPR12

Summary ?
GeneID2835
SymbolGPR12
SynonymsGPCR12|GPCR21|PPP1R84
DescriptionG protein-coupled receptor 12
ReferenceMIM:600752|HGNC:HGNC:4466|Ensembl:ENSG00000132975|HPRD:15978|Vega:OTTHUMG00000016620
Gene typeprotein-coding
Map location13q12
Pascal p-value0.703
Fetal beta2.08
DMG1 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
Nucleus accumbens basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg210871081327335360GPR121.861E-40.4430.034DMG:Wockner_2014
cg159055791327335084GPR123.242E-4-0.2060.04DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SLC6A120.910.92
TBX20.870.83
HLA-E0.860.89
GPR37L10.840.88
PRELP0.840.89
HEPACAM0.820.85
SFXN50.820.83
ACSBG10.810.84
SELENBP10.810.82
GRIN2C0.810.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FRG1-0.70-0.78
GNL3-0.70-0.74
SUPV3L1-0.69-0.76
ZBED5-0.69-0.77
MED19-0.69-0.73
C11orf57-0.69-0.80
DUSP12-0.68-0.73
ZNF461-0.68-0.75
ZNF239-0.68-0.73
ASNSD1-0.68-0.72

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001619lysosphingolipid and lysophosphatidic acid receptor activityIEA-
GO:0004872receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS8530049 
GO:0007165signal transductionIEA-
GO:0006874cellular calcium ion homeostasisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8530049 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
SHIPP DLBCL CURED VS FATAL UP 3922All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
SU SALIVARY GLAND 169All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 7757All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK DN 2013All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway