Gene Page: GPR17
Summary ?
| GeneID | 2840 |
| Symbol | GPR17 |
| Synonyms | - |
| Description | G protein-coupled receptor 17 |
| Reference | MIM:603071|HGNC:HGNC:4471|Ensembl:ENSG00000144230|HPRD:04351|Vega:OTTHUMG00000131533 |
| Gene type | protein-coding |
| Map location | 2q21 |
| Pascal p-value | 0.552 |
| Fetal beta | -2.222 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.023 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.00755 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2540862 | chr14 | 91700845 | GPR17 | 2840 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| P2RY12 | 0.84 | 0.89 |
| CD86 | 0.84 | 0.82 |
| ADORA3 | 0.82 | 0.81 |
| RGS10 | 0.81 | 0.85 |
| C1QC | 0.81 | 0.81 |
| TBXAS1 | 0.80 | 0.81 |
| SAMSN1 | 0.80 | 0.84 |
| C1QA | 0.79 | 0.77 |
| RNASE6 | 0.79 | 0.79 |
| LAPTM5 | 0.78 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HIP1R | -0.38 | -0.39 |
| DMPK | -0.35 | -0.43 |
| TNKS1BP1 | -0.35 | -0.33 |
| SMTN | -0.35 | -0.48 |
| SAFB2 | -0.34 | -0.31 |
| CEP250 | -0.34 | -0.30 |
| PABPN1 | -0.33 | -0.38 |
| UPF3A | -0.33 | -0.40 |
| SFRS16 | -0.33 | -0.33 |
| UCP3 | -0.33 | -0.36 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0004950 | chemokine receptor activity | TAS | 8558062 | |
| GO:0045028 | purinergic nucleotide receptor activity, G-protein coupled | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | TAS | 8558062 | |
| GO:0007165 | signal transduction | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 8558062 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | 205 | 136 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA Q SIGNALLING EVENTS | 184 | 116 | All SZGR 2.0 genes in this pathway |
| REACTOME P2Y RECEPTORS | 12 | 5 | All SZGR 2.0 genes in this pathway |
| REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | 16 | 8 | All SZGR 2.0 genes in this pathway |
| REACTOME EICOSANOID LIGAND BINDING RECEPTORS | 16 | 6 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA I SIGNALLING EVENTS | 195 | 114 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| HARRIS BRAIN CANCER PROGENITORS | 44 | 23 | All SZGR 2.0 genes in this pathway |
| RIGGI EWING SARCOMA PROGENITOR UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| TAVAZOIE METASTASIS | 108 | 68 | All SZGR 2.0 genes in this pathway |
| VERHAAK GLIOBLASTOMA PRONEURAL | 177 | 132 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 DN | 42 | 24 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 5 DN | 50 | 31 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 6 DN | 38 | 19 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |