Gene Page: GPS2
Summary ?
| GeneID | 2874 |
| Symbol | GPS2 |
| Synonyms | AMF-1 |
| Description | G protein pathway suppressor 2 |
| Reference | MIM:601935|HGNC:HGNC:4550|Ensembl:ENSG00000132522|HPRD:11878|Vega:OTTHUMG00000102198 |
| Gene type | protein-coding |
| Map location | 17p13 |
| Sherlock p-value | 0.302 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg04239855 | 17 | 7218050 | GPS2 | 4.1E-8 | -0.019 | 1.15E-5 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BTBD9 | 0.88 | 0.88 |
| CNKSR2 | 0.88 | 0.89 |
| CDC40 | 0.88 | 0.88 |
| SCN3B | 0.88 | 0.87 |
| WDR17 | 0.87 | 0.90 |
| ARHGEF9 | 0.87 | 0.85 |
| C9orf4 | 0.87 | 0.87 |
| MADD | 0.87 | 0.87 |
| MYCBP2 | 0.87 | 0.87 |
| ZC3H12B | 0.87 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.55 | -0.54 |
| C1orf54 | -0.54 | -0.62 |
| HIGD1B | -0.54 | -0.57 |
| RHOC | -0.53 | -0.62 |
| ENHO | -0.53 | -0.58 |
| C1orf61 | -0.52 | -0.63 |
| PLA2G5 | -0.51 | -0.51 |
| MT-CO2 | -0.51 | -0.53 |
| EIF4EBP3 | -0.51 | -0.53 |
| FXYD1 | -0.51 | -0.51 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ATF4 | CREB-2 | CREB2 | TAXREB67 | TXREB | activating transcription factor 4 (tax-responsive enhancer element B67) | Two-hybrid | BioGRID | 16189514 |
| C19orf57 | MGC11271 | MGC149720 | chromosome 19 open reading frame 57 | Two-hybrid | BioGRID | 16189514 |
| C21orf7 | HC21ORF7 | TAK1L | TAKL | TAKL-1 | TAKL-2 | TAKL-4 | chromosome 21 open reading frame 7 | Affinity Capture-Western Two-hybrid | BioGRID | 16189514 |
| CCDC99 | FLJ20364 | FLJ40690 | coiled-coil domain containing 99 | Two-hybrid | BioGRID | 16169070 |
| CCNA1 | - | cyclin A1 | - | HPRD,BioGRID | 15159402 |
| CCNA1 | - | cyclin A1 | cyclin A1 interacts with GPS2. | BIND | 15159402 |
| CHD3 | Mi-2a | Mi2-ALPHA | ZFH | chromodomain helicase DNA binding protein 3 | Two-hybrid | BioGRID | 16169070 |
| DBNL | ABP1 | HIP-55 | SH3P7 | drebrin-like | Affinity Capture-MS | BioGRID | 17353931 |
| EP300 | KAT3B | p300 | E1A binding protein p300 | - | HPRD,BioGRID | 10846067 |
| GOLGA2 | GM130 | MGC20672 | golgi autoantigen, golgin subfamily a, 2 | Two-hybrid | BioGRID | 16169070 |
| GPS2 | AMF-1 | MGC104294 | MGC119287 | MGC119288 | MGC119289 | G protein pathway suppressor 2 | AMF1 oligomerizes with itself to form a complex with an unknown number of subunits. | BIND | 11486030 |
| HDAC3 | HD3 | RPD3 | RPD3-2 | histone deacetylase 3 | Affinity Capture-MS Affinity Capture-Western | BioGRID | 11931768 |
| HDAC5 | FLJ90614 | HD5 | NY-CO-9 | histone deacetylase 5 | Affinity Capture-Western | BioGRID | 11931768 |
| NCOR1 | KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR | nuclear receptor co-repressor 1 | - | HPRD,BioGRID | 11931768 |
| NCOR1 | KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR | nuclear receptor co-repressor 1 | N-CoR interacts with GPS2. | BIND | 12628926 |
| PBK | FLJ14385 | Nori-3 | SPK | TOPK | PDZ binding kinase | Two-hybrid | BioGRID | 16169070 |
| SETDB1 | ESET | KG1T | KIAA0067 | KMT1E | SET domain, bifurcated 1 | Two-hybrid | BioGRID | 16169070 |
| TBL1X | EBI | SMAP55 | TBL1 | transducin (beta)-like 1X-linked | GPS2 interacts with TBL1X (TBL1). | BIND | 11931768 |
| TBL1X | EBI | SMAP55 | TBL1 | transducin (beta)-like 1X-linked | - | HPRD,BioGRID | 11931768 |
| TBL1XR1 | C21 | DC42 | FLJ12894 | IRA1 | TBLR1 | transducin (beta)-like 1 X-linked receptor 1 | - | HPRD | 11931768 |
| TP53 | FLJ92943 | LFS1 | TRP53 | p53 | tumor protein p53 | - | HPRD,BioGRID | 11486030 |
| TP53 | FLJ92943 | LFS1 | TRP53 | p53 | tumor protein p53 | p53 interacts with AMF1 | BIND | 11486030 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MULLIGHAN MLL SIGNATURE 2 UP | 418 | 263 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER UP | 181 | 108 | All SZGR 2.0 genes in this pathway |
| MARTORIATI MDM4 TARGETS FETAL LIVER DN | 514 | 319 | All SZGR 2.0 genes in this pathway |
| POMEROY MEDULLOBLASTOMA PROGNOSIS UP | 47 | 30 | All SZGR 2.0 genes in this pathway |
| HASLINGER B CLL WITH 17P13 DELETION | 21 | 15 | All SZGR 2.0 genes in this pathway |
| TAKAO RESPONSE TO UVB RADIATION UP | 86 | 55 | All SZGR 2.0 genes in this pathway |
| DAZARD RESPONSE TO UV NHEK UP | 244 | 151 | All SZGR 2.0 genes in this pathway |
| WELCSH BRCA1 TARGETS UP | 198 | 132 | All SZGR 2.0 genes in this pathway |
| HSIAO HOUSEKEEPING GENES | 389 | 245 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH T 8 21 TRANSLOCATION | 368 | 247 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH 11Q23 REARRANGED | 351 | 238 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |