SZGR2

Summary ?

GeneID	2887
Symbol	GRB10
Synonyms	GRB-IR\|Grb-10\|IRBP\|MEG1\|RSS
Description	growth factor receptor bound protein 10
Reference	MIM:601523\|HGNC:HGNC:4564\|Ensembl:ENSG00000106070\|HPRD:03312\|Vega:OTTHUMG00000150622
Gene type	protein-coding
Map location	7p12.2
Pascal p-value	0.005
Fetal beta	-0.079
Support	G2Cdb.humanPSD G2Cdb.humanPSP Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWAScat	Genome-wide Association Studies	This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0161

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MLL2	0.83	0.86
PRICKLE2	0.83	0.85
RAPH1	0.83	0.86
C12orf51	0.82	0.84
RNF150	0.82	0.84
TANC2	0.82	0.85
KIAA2018	0.81	0.83
XKR4	0.80	0.85
SOCS7	0.80	0.84
CUGBP2	0.80	0.81

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SERPINB6	-0.58	-0.70
RHOC	-0.54	-0.69
BDH2	-0.51	-0.62
FXYD1	-0.51	-0.66
TLCD1	-0.50	-0.66
DCXR	-0.50	-0.62
DBI	-0.50	-0.69
S100A16	-0.50	-0.66
SAT1	-0.50	-0.71
AC021016.1	-0.50	-0.66

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005070	SH3/SH2 adaptor activity	TAS		9006901
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		8798570
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007267	cell-cell signaling	TAS		9006901
GO:0007165	signal transduction	IEA		-
GO:0008286	insulin receptor signaling pathway	TAS		9006901
GO:0048009	insulin-like growth factor receptor signaling pathway	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	TAS		9006901
GO:0005886	plasma membrane	TAS		9006901

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	Affinity Capture-Western Reconstituted Complex	BioGRID	9006901 \|9747873
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD	11809791
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	-	HPRD,BioGRID	9747873
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Grb10 interacts with EGFR.	BIND	9506989
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	9006901 \|9506989
ELK1	-	ELK1, member of ETS oncogene family	-	HPRD	8798570
EPHB1	ELK \| EPHT2 \| FLJ37986 \| Hek6 \| NET	EPH receptor B1	Two-hybrid	BioGRID	8798570
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	10871840
GHR	GHBP	growth hormone receptor	-	HPRD,BioGRID	9632636
GIGYF1	GYF1 \| PERQ1	GRB10 interacting GYF protein 1	-	HPRD,BioGRID	12771153
GIGYF2	DKFZp686I15154 \| DKFZp686J17223 \| FLJ23368 \| GYF2 \| KIAA0642 \| PARK11 \| PERQ2 \| PERQ3 \| TNRC15	GRB10 interacting GYF protein 2	-	HPRD,BioGRID	12771153
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	-	HPRD	8621530 \|8764099
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	Grb10 interacts with IGFIR.	BIND	9506989
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	Affinity Capture-Western in vitro in vivo Reconstituted Complex Two-hybrid	BioGRID	8764099 \|8776723 \|9506989 \|12697834
INSR	CD220 \| HHF5	insulin receptor	Grb10 interacts with IR.	BIND	9506989
INSR	CD220 \| HHF5	insulin receptor	-	HPRD,BioGRID	7479769 \|8621530
IRS1	HIRS-1	insulin receptor substrate 1	Reconstituted Complex	BioGRID	8621530
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD,BioGRID	9632636
KDR	CD309 \| FLK1 \| VEGFR \| VEGFR2	kinase insert domain receptor (a type III receptor tyrosine kinase)	-	HPRD,BioGRID	11494124
KIT	C-Kit \| CD117 \| PBT \| SCFR	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	-	HPRD,BioGRID	11809791
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	-	HPRD,BioGRID	9553107
MEGF10	DKFZp781K1852 \| FLJ41574 \| KIAA1780	multiple EGF-like-domains 10	-	HPRD	12421765
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	neural precursor cell expressed, developmentally down-regulated 4	-	HPRD	12697834
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	neural precursor cell expressed, developmentally down-regulated 4	-	HPRD	10446181 \|12697834\|12697834
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD	9006901
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	9553107 \|10585452
RET	CDHF12 \| HSCR1 \| MEN2A \| MEN2B \| MTC1 \| PTC \| RET-ELE1 \| RET51	ret proto-oncogene	-	HPRD,BioGRID	7665556
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Biochemical Activity	BioGRID	10871840

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID INSULIN PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID RET PATHWAY	39	29	All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID KIT PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR	108	72	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL ATTENUATION	14	8	All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN	92	51	All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS UP	52	38	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP	127	78	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN	50	36	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP	112	68	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN	214	133	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP	164	122	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP	162	116	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN	142	95	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN	229	142	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN	394	258	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP	197	135	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP	169	127	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5	147	89	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER	111	69	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN	203	134	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
GOUYER TUMOR INVASIVENESS	9	5	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 MCF10A	43	26	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP	256	159	All SZGR 2.0 genes in this pathway
ROSS AML WITH PML RARA FUSION	77	62	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION UP	140	83	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 DN	15	12	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN	215	132	All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO CAMPTOTHECIN UP	28	18	All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA DN	23	14	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS DN	25	21	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL	311	205	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP	280	183	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5	482	296	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY DN	44	29	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED	536	296	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3	269	159	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 2	29	14	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS INTERFERON DN	52	30	All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3	435	318	All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY UP	36	23	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION TOP20 DN	18	12	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN	321	200	All SZGR 2.0 genes in this pathway
WANG MLL TARGETS	289	188	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP	279	155	All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES	63	47	All SZGR 2.0 genes in this pathway
ZHANG ADIPOGENESIS BY BMP7	14	12	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	2338	2344	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	2338	2344	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-181	2320	2327	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-199	39	46	1A,m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	39	46	1A,m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-30-5p	367	373	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GRB10