Gene Page: GRIA1

Summary ?
GeneID2890
SymbolGRIA1
SynonymsGLUH1|GLUR1|GLURA|GluA1|HBGR1
Descriptionglutamate ionotropic receptor AMPA type subunit 1
ReferenceMIM:138248|HGNC:HGNC:4571|Ensembl:ENSG00000155511|HPRD:00695|Vega:OTTHUMG00000130148
Gene typeprotein-coding
Map location5q31.1
Pascal p-value0.197
Fetal beta-0.218
eGeneMyers' cis & trans
SupportLIGAND GATED ION SIGNALING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanARC
G2Cdb.humanPSD
G2Cdb.humanPSP
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_IGenome scan meta-analysisPsr: 0.0032 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00459 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4005 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4958734chr5153789504GRIA128900.1cis
rs6712415chr2133868796GRIA128900.05trans
rs10184338chr2133868936GRIA128900.07trans
rs10172235chr2133869155GRIA128900.17trans
rs17029291chr332402138GRIA128908.566E-5trans
rs3988303chr819776538GRIA128900.15trans
rs11793484chr9317239GRIA128900.03trans
rs10970457chr9326183GRIA128900.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PORCN0.900.87
C3orf390.890.88
SCYL10.890.87
FAM127A0.880.86
ATP6AP10.880.87
RNF1230.870.83
ACP20.860.85
SLC45A10.860.87
CDIPT0.860.86
C17orf280.850.82
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.58-0.44
AF347015.18-0.56-0.48
NSBP1-0.56-0.55
AL139819.3-0.53-0.51
MT-ATP8-0.52-0.42
AF347015.8-0.52-0.39
GNG11-0.52-0.45
MT-CO2-0.50-0.37
NOSTRIN-0.50-0.39
AF347015.31-0.50-0.37

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005234extracellular-glutamate-gated ion channel activityIEAglutamate (GO term level: 11)-
GO:0015277kainate selective glutamate receptor activityTASglutamate (GO term level: 8)1311100 
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0005216ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)1311100 
GO:0007165signal transductionTAS1311100 
GO:0007616long-term memoryIEA-
GO:0006811ion transportIEA-
GO:0031623receptor internalizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0014069postsynaptic densityIEASynap (GO term level: 10)-
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005624membrane fractionIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS1311100 
GO:0030054cell junctionIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CACNG2MGC138502 | MGC138504calcium channel, voltage-dependent, gamma subunit 2-HPRD,BioGRID11140673 
CANXCNX | FLJ26570 | IP90 | P90calnexin-HPRD10461883 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD,BioGRID9677374 |11567040 
EPB41L14.1N | DKFZp686H17242 | KIAA0338 | MGC11072erythrocyte membrane protein band 4.1-like 1-HPRD,BioGRID11050113 
EPB41L24.1-G | DKFZp781D1972 | DKFZp781H1755erythrocyte membrane protein band 4.1-like 2-HPRD,BioGRID11050113 
GRIA2GLUR2 | GLURB | GluR-K2 | HBGR2glutamate receptor, ionotropic, AMPA 2Affinity Capture-WesternBioGRID10358037 
GRIA4GLUR4 | GLUR4C | GLURDglutamate receptor, ionotrophic, AMPA 4-HPRD,BioGRID9466455 
GRID2MGC117022 | MGC117023 | MGC117024glutamate receptor, ionotropic, delta 2Affinity Capture-WesternBioGRID12573530 
GRID2MGC117022 | MGC117023 | MGC117024glutamate receptor, ionotropic, delta 2GluR1 interacts with GluR-delta-2BIND12573530 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2Affinity Capture-WesternBioGRID8288598 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2-HPRD10358037 
GRIP1GRIPglutamate receptor interacting protein 1Reconstituted ComplexBioGRID11891216 
HOMER1HOMER | HOMER1A | HOMER1B | HOMER1C | SYN47 | Ves-1homer homolog 1 (Drosophila)-HPRD,BioGRID9069287 |9808458 
|11418862 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)-HPRD10461883 
PICK1MGC15204 | PICK | PRKCABPprotein interacting with PRKCA 1-HPRD,BioGRID11891216 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)-HPRD,BioGRID11891216 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
TRPC1HTRP-1 | MGC133334 | MGC133335 | TRP1transient receptor potential cation channel, subfamily C, member 1-HPRD14614461 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 7057All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 7053All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 5343All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 4038All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS 2823All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 1611All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 3732All SZGR 2.0 genes in this pathway
REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION 1514All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195138All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU DN 8369All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL 6350All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153120All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN 4031All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 7962All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 10573All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180125All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP 6144All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229135All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway