Gene Page: C11orf54
Summary ?
| GeneID | 28970 |
| Symbol | C11orf54 |
| Synonyms | PTD012|PTOD012 |
| Description | chromosome 11 open reading frame 54 |
| Reference | MIM:615810|HGNC:HGNC:30204|Ensembl:ENSG00000182919|HPRD:17923|Vega:OTTHUMG00000167452 |
| Gene type | protein-coding |
| Map location | 11q21 |
| Pascal p-value | 0.146 |
| Sherlock p-value | 0.772 |
| Fetal beta | 0.699 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg01618304 | 11 | 93474888 | C11orf54 | -0.02 | 0.57 | DMG:Nishioka_2013 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6674970 | chr1 | 151116278 | C11orf54 | 28970 | 0.07 | trans | ||
| rs1701843 | chr7 | 113008822 | C11orf54 | 28970 | 0.01 | trans | ||
| rs7943266 | 11 | 93476627 | C11orf54 | ENSG00000182919.10 | 1.68E-9 | 0 | 1498 | gtex_brain_putamen_basal |
| rs652961 | 11 | 93476766 | C11orf54 | ENSG00000182919.10 | 1.869E-10 | 0 | 1637 | gtex_brain_putamen_basal |
| rs7943525 | 11 | 93476860 | C11orf54 | ENSG00000182919.10 | 9.885E-10 | 0 | 1731 | gtex_brain_putamen_basal |
| rs10741476 | 11 | 93477621 | C11orf54 | ENSG00000182919.10 | 1.632E-9 | 0 | 2492 | gtex_brain_putamen_basal |
| rs11020505 | 11 | 93478133 | C11orf54 | ENSG00000182919.10 | 1.626E-9 | 0 | 3004 | gtex_brain_putamen_basal |
| rs11020506 | 11 | 93478342 | C11orf54 | ENSG00000182919.10 | 1.624E-9 | 0 | 3213 | gtex_brain_putamen_basal |
| rs11020507 | 11 | 93478528 | C11orf54 | ENSG00000182919.10 | 1.624E-9 | 0 | 3399 | gtex_brain_putamen_basal |
| rs595650 | 11 | 93480190 | C11orf54 | ENSG00000182919.10 | 1.627E-9 | 0 | 5061 | gtex_brain_putamen_basal |
| rs624856 | 11 | 93480708 | C11orf54 | ENSG00000182919.10 | 1.491E-9 | 0 | 5579 | gtex_brain_putamen_basal |
| rs665507 | 11 | 93481155 | C11orf54 | ENSG00000182919.10 | 1.626E-9 | 0 | 6026 | gtex_brain_putamen_basal |
| rs640379 | 11 | 93481908 | C11orf54 | ENSG00000182919.10 | 1.515E-9 | 0 | 6779 | gtex_brain_putamen_basal |
| rs1284141 | 11 | 93482094 | C11orf54 | ENSG00000182919.10 | 9.889E-10 | 0 | 6965 | gtex_brain_putamen_basal |
| rs11020510 | 11 | 93482403 | C11orf54 | ENSG00000182919.10 | 1.854E-10 | 0 | 7274 | gtex_brain_putamen_basal |
| rs681321 | 11 | 93483346 | C11orf54 | ENSG00000182919.10 | 5.179E-11 | 0 | 8217 | gtex_brain_putamen_basal |
| rs1783938 | 11 | 93486384 | C11orf54 | ENSG00000182919.10 | 1.624E-9 | 0 | 11255 | gtex_brain_putamen_basal |
| rs397828224 | 11 | 93486526 | C11orf54 | ENSG00000182919.10 | 1.38E-8 | 0 | 11397 | gtex_brain_putamen_basal |
| rs606462 | 11 | 93487418 | C11orf54 | ENSG00000182919.10 | 1.681E-9 | 0 | 12289 | gtex_brain_putamen_basal |
| rs621355 | 11 | 93487595 | C11orf54 | ENSG00000182919.10 | 1.684E-9 | 0 | 12466 | gtex_brain_putamen_basal |
| rs6483265 | 11 | 93488092 | C11orf54 | ENSG00000182919.10 | 4.55E-8 | 0 | 12963 | gtex_brain_putamen_basal |
| rs2510603 | 11 | 93488192 | C11orf54 | ENSG00000182919.10 | 1.022E-6 | 0 | 13063 | gtex_brain_putamen_basal |
| rs2434978 | 11 | 93488199 | C11orf54 | ENSG00000182919.10 | 6.97E-8 | 0 | 13070 | gtex_brain_putamen_basal |
| rs7950574 | 11 | 93489203 | C11orf54 | ENSG00000182919.10 | 8.09E-9 | 0 | 14074 | gtex_brain_putamen_basal |
| rs602242 | 11 | 93490219 | C11orf54 | ENSG00000182919.10 | 1.684E-9 | 0 | 15090 | gtex_brain_putamen_basal |
| rs602665 | 11 | 93490307 | C11orf54 | ENSG00000182919.10 | 1.684E-9 | 0 | 15178 | gtex_brain_putamen_basal |
| rs670871 | 11 | 93491020 | C11orf54 | ENSG00000182919.10 | 1.69E-9 | 0 | 15891 | gtex_brain_putamen_basal |
| rs616876 | 11 | 93491179 | C11orf54 | ENSG00000182919.10 | 1.684E-9 | 0 | 16050 | gtex_brain_putamen_basal |
| rs653939 | 11 | 93491464 | C11orf54 | ENSG00000182919.10 | 1.815E-9 | 0 | 16335 | gtex_brain_putamen_basal |
| rs618801 | 11 | 93491645 | C11orf54 | ENSG00000182919.10 | 1.536E-9 | 0 | 16516 | gtex_brain_putamen_basal |
| rs631177 | 11 | 93492058 | C11orf54 | ENSG00000182919.10 | 1.684E-9 | 0 | 16929 | gtex_brain_putamen_basal |
| rs640382 | 11 | 93492203 | C11orf54 | ENSG00000182919.10 | 1.475E-9 | 0 | 17074 | gtex_brain_putamen_basal |
| rs631705 | 11 | 93492232 | C11orf54 | ENSG00000182919.10 | 1.687E-9 | 0 | 17103 | gtex_brain_putamen_basal |
| rs1284102 | 11 | 93492355 | C11orf54 | ENSG00000182919.10 | 1.687E-9 | 0 | 17226 | gtex_brain_putamen_basal |
| rs606286 | 11 | 93493691 | C11orf54 | ENSG00000182919.10 | 4.448E-9 | 0 | 18562 | gtex_brain_putamen_basal |
| rs606749 | 11 | 93493825 | C11orf54 | ENSG00000182919.10 | 1.507E-9 | 0 | 18696 | gtex_brain_putamen_basal |
| rs659877 | 11 | 93493911 | C11orf54 | ENSG00000182919.10 | 1.316E-8 | 0 | 18782 | gtex_brain_putamen_basal |
| rs607615 | 11 | 93493989 | C11orf54 | ENSG00000182919.10 | 1.534E-9 | 0 | 18860 | gtex_brain_putamen_basal |
| rs611762 | 11 | 93494005 | C11orf54 | ENSG00000182919.10 | 5.469E-9 | 0 | 18876 | gtex_brain_putamen_basal |
| rs201221620 | 11 | 93494874 | C11orf54 | ENSG00000182919.10 | 2.231E-7 | 0 | 19745 | gtex_brain_putamen_basal |
| rs72097212 | 11 | 93494878 | C11orf54 | ENSG00000182919.10 | 1.511E-9 | 0 | 19749 | gtex_brain_putamen_basal |
| rs606357 | 11 | 93496377 | C11orf54 | ENSG00000182919.10 | 2.012E-10 | 0 | 21248 | gtex_brain_putamen_basal |
| rs666136 | 11 | 93496563 | C11orf54 | ENSG00000182919.10 | 1.519E-9 | 0 | 21434 | gtex_brain_putamen_basal |
| rs628661 | 11 | 93498126 | C11orf54 | ENSG00000182919.10 | 1.512E-9 | 0 | 22997 | gtex_brain_putamen_basal |
| rs630811 | 11 | 93498552 | C11orf54 | ENSG00000182919.10 | 1.532E-9 | 0 | 23423 | gtex_brain_putamen_basal |
| rs1284108 | 11 | 93498833 | C11orf54 | ENSG00000182919.10 | 2.028E-9 | 0 | 23704 | gtex_brain_putamen_basal |
| rs644535 | 11 | 93499361 | C11orf54 | ENSG00000182919.10 | 1.483E-9 | 0 | 24232 | gtex_brain_putamen_basal |
| rs56364420 | 11 | 93500659 | C11orf54 | ENSG00000182919.10 | 2.106E-10 | 0 | 25530 | gtex_brain_putamen_basal |
| rs12803773 | 11 | 93500869 | C11orf54 | ENSG00000182919.10 | 1.172E-6 | 0 | 25740 | gtex_brain_putamen_basal |
| rs138241708 | 11 | 93500889 | C11orf54 | ENSG00000182919.10 | 7.756E-8 | 0 | 25760 | gtex_brain_putamen_basal |
| rs10765633 | 11 | 93501015 | C11orf54 | ENSG00000182919.10 | 1.469E-9 | 0 | 25886 | gtex_brain_putamen_basal |
| rs10765634 | 11 | 93501093 | C11orf54 | ENSG00000182919.10 | 7.614E-8 | 0 | 25964 | gtex_brain_putamen_basal |
| rs3132751 | 11 | 93501140 | C11orf54 | ENSG00000182919.10 | 1.645E-9 | 0 | 26011 | gtex_brain_putamen_basal |
| rs3132750 | 11 | 93501148 | C11orf54 | ENSG00000182919.10 | 1.49E-9 | 0 | 26019 | gtex_brain_putamen_basal |
| rs688634 | 11 | 93504852 | C11orf54 | ENSG00000182919.10 | 4.009E-8 | 0 | 29723 | gtex_brain_putamen_basal |
| rs675441 | 11 | 93505490 | C11orf54 | ENSG00000182919.10 | 3.343E-7 | 0 | 30361 | gtex_brain_putamen_basal |
| rs658181 | 11 | 93506034 | C11orf54 | ENSG00000182919.10 | 5.416E-8 | 0 | 30905 | gtex_brain_putamen_basal |
| rs34014213 | 11 | 93506780 | C11orf54 | ENSG00000182919.10 | 8.462E-7 | 0 | 31651 | gtex_brain_putamen_basal |
| rs80312811 | 11 | 93506787 | C11orf54 | ENSG00000182919.10 | 8.465E-7 | 0 | 31658 | gtex_brain_putamen_basal |
| rs585713 | 11 | 93507249 | C11orf54 | ENSG00000182919.10 | 7.014E-8 | 0 | 32120 | gtex_brain_putamen_basal |
| rs586293 | 11 | 93507935 | C11orf54 | ENSG00000182919.10 | 8.241E-8 | 0 | 32806 | gtex_brain_putamen_basal |
| rs693947 | 11 | 93508243 | C11orf54 | ENSG00000182919.10 | 3.207E-7 | 0 | 33114 | gtex_brain_putamen_basal |
| rs199911190 | 11 | 93509184 | C11orf54 | ENSG00000182919.10 | 5.476E-8 | 0 | 34055 | gtex_brain_putamen_basal |
| rs201211012 | 11 | 93509185 | C11orf54 | ENSG00000182919.10 | 1.004E-7 | 0 | 34056 | gtex_brain_putamen_basal |
| rs625249 | 11 | 93510141 | C11orf54 | ENSG00000182919.10 | 8.84E-8 | 0 | 35012 | gtex_brain_putamen_basal |
| rs675501 | 11 | 93510488 | C11orf54 | ENSG00000182919.10 | 8.947E-8 | 0 | 35359 | gtex_brain_putamen_basal |
| rs200173841 | 11 | 93510646 | C11orf54 | ENSG00000182919.10 | 1.077E-6 | 0 | 35517 | gtex_brain_putamen_basal |
| rs200697487 | 11 | 93510647 | C11orf54 | ENSG00000182919.10 | 1.563E-8 | 0 | 35518 | gtex_brain_putamen_basal |
| rs623017 | 11 | 93510648 | C11orf54 | ENSG00000182919.10 | 2.353E-8 | 0 | 35519 | gtex_brain_putamen_basal |
| rs664619 | 11 | 93510656 | C11orf54 | ENSG00000182919.10 | 5.795E-7 | 0 | 35527 | gtex_brain_putamen_basal |
| rs622147 | 11 | 93510858 | C11orf54 | ENSG00000182919.10 | 9.055E-8 | 0 | 35729 | gtex_brain_putamen_basal |
| rs4753103 | 11 | 93511119 | C11orf54 | ENSG00000182919.10 | 7.834E-8 | 0 | 35990 | gtex_brain_putamen_basal |
| rs12292460 | 11 | 93511562 | C11orf54 | ENSG00000182919.10 | 9.937E-8 | 0 | 36433 | gtex_brain_putamen_basal |
| rs4753501 | 11 | 93512152 | C11orf54 | ENSG00000182919.10 | 5.215E-7 | 0 | 37023 | gtex_brain_putamen_basal |
| rs2434984 | 11 | 93512915 | C11orf54 | ENSG00000182919.10 | 8.915E-8 | 0 | 37786 | gtex_brain_putamen_basal |
| rs10831102 | 11 | 93513206 | C11orf54 | ENSG00000182919.10 | 9.055E-8 | 0 | 38077 | gtex_brain_putamen_basal |
| rs397840997 | 11 | 93514833 | C11orf54 | ENSG00000182919.10 | 2.339E-8 | 0 | 39704 | gtex_brain_putamen_basal |
| rs598376 | 11 | 93515058 | C11orf54 | ENSG00000182919.10 | 9.055E-8 | 0 | 39929 | gtex_brain_putamen_basal |
| rs598427 | 11 | 93515103 | C11orf54 | ENSG00000182919.10 | 9.068E-8 | 0 | 39974 | gtex_brain_putamen_basal |
| rs1428919 | 11 | 93516016 | C11orf54 | ENSG00000182919.10 | 9.055E-8 | 0 | 40887 | gtex_brain_putamen_basal |
| rs662070 | 11 | 93516204 | C11orf54 | ENSG00000182919.10 | 8.679E-8 | 0 | 41075 | gtex_brain_putamen_basal |
| rs640864 | 11 | 93516432 | C11orf54 | ENSG00000182919.10 | 9.055E-8 | 0 | 41303 | gtex_brain_putamen_basal |
| rs652621 | 11 | 93516772 | C11orf54 | ENSG00000182919.10 | 9.055E-8 | 0 | 41643 | gtex_brain_putamen_basal |
| rs655158 | 11 | 93517299 | C11orf54 | ENSG00000182919.10 | 9.055E-8 | 0 | 42170 | gtex_brain_putamen_basal |
| rs7116967 | 11 | 93517874 | C11orf54 | ENSG00000182919.10 | 8.579E-8 | 0 | 42745 | gtex_brain_putamen_basal |
| rs2848477 | 11 | 93517886 | C11orf54 | ENSG00000182919.10 | 8.606E-8 | 0 | 42757 | gtex_brain_putamen_basal |
| rs532888132 | 11 | 93519170 | C11orf54 | ENSG00000182919.10 | 1.131E-6 | 0 | 44041 | gtex_brain_putamen_basal |
| rs588644 | 11 | 93519673 | C11orf54 | ENSG00000182919.10 | 6.013E-8 | 0 | 44544 | gtex_brain_putamen_basal |
| rs658797 | 11 | 93519737 | C11orf54 | ENSG00000182919.10 | 8.723E-8 | 0 | 44608 | gtex_brain_putamen_basal |
| rs658698 | 11 | 93527684 | C11orf54 | ENSG00000182919.10 | 5.842E-7 | 0 | 52555 | gtex_brain_putamen_basal |
| rs655699 | 11 | 93534990 | C11orf54 | ENSG00000182919.10 | 5.842E-7 | 0 | 59861 | gtex_brain_putamen_basal |
| rs11020521 | 11 | 93538992 | C11orf54 | ENSG00000182919.10 | 1.451E-9 | 0 | 63863 | gtex_brain_putamen_basal |
| rs11020522 | 11 | 93539050 | C11orf54 | ENSG00000182919.10 | 5.842E-7 | 0 | 63921 | gtex_brain_putamen_basal |
| rs673869 | 11 | 93540001 | C11orf54 | ENSG00000182919.10 | 5.842E-7 | 0 | 64872 | gtex_brain_putamen_basal |
| rs644009 | 11 | 93550568 | C11orf54 | ENSG00000182919.10 | 5.842E-7 | 0 | 75439 | gtex_brain_putamen_basal |
| rs11286324 | 11 | 93550744 | C11orf54 | ENSG00000182919.10 | 8.867E-8 | 0 | 75615 | gtex_brain_putamen_basal |
| rs601711 | 11 | 93564393 | C11orf54 | ENSG00000182919.10 | 7.006E-7 | 0 | 89264 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN | 634 | 384 | All SZGR 2.0 genes in this pathway |
| JAATINEN HEMATOPOIETIC STEM CELL UP | 316 | 190 | All SZGR 2.0 genes in this pathway |
| LANDIS ERBB2 BREAST TUMORS 324 UP | 150 | 93 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR UP | 487 | 286 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | 172 | 107 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL LONG TERM | 302 | 191 | All SZGR 2.0 genes in this pathway |
| VARELA ZMPSTE24 TARGETS DN | 38 | 18 | All SZGR 2.0 genes in this pathway |
| TSENG IRS1 TARGETS DN | 135 | 88 | All SZGR 2.0 genes in this pathway |
| WENG POR TARGETS LIVER UP | 41 | 29 | All SZGR 2.0 genes in this pathway |
| ZHANG BREAST CANCER PROGENITORS UP | 425 | 253 | All SZGR 2.0 genes in this pathway |
| RAY TUMORIGENESIS BY ERBB2 CDC25A DN | 159 | 105 | All SZGR 2.0 genes in this pathway |
| ELLWOOD MYC TARGETS DN | 40 | 27 | All SZGR 2.0 genes in this pathway |
| WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 | 181 | 101 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | All SZGR 2.0 genes in this pathway |
| CHYLA CBFA2T3 TARGETS UP | 387 | 225 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |
| ZWANG DOWN BY 2ND EGF PULSE | 293 | 119 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |