Gene Page: SPCS1

Summary ?
GeneID28972
SymbolSPCS1
SynonymsHSPC033|SPC1|SPC12|YJR010C-A
Descriptionsignal peptidase complex subunit 1
ReferenceMIM:610358|HGNC:HGNC:23401|Ensembl:ENSG00000114902|
Gene typeprotein-coding
Map location3p21.1
Pascal p-value1.853E-7
Sherlock p-value0.234
Fetal beta-0.66
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
LK:YESGenome-wide Association StudyThis data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PROTEIN EXPORT 2416All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION 22275All SZGR 2.0 genes in this pathway
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 17953All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM 12084All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION 9365All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 1611All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP 148All SZGR 2.0 genes in this pathway
REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION 2214All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 1912All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378231All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN 9859All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283177All SZGR 2.0 genes in this pathway
MORI PLASMA CELL UP 5129All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL TRANS 65All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 12284All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 172107All SZGR 2.0 genes in this pathway