Summary ?
GeneID29079
SymbolMED4
SynonymsARC36|DRIP36|HSPC126|TRAP36|VDRIP
Descriptionmediator complex subunit 4
ReferenceMIM:605718|HGNC:HGNC:17903|Ensembl:ENSG00000136146|HPRD:16145|Vega:OTTHUMG00000016891
Gene typeprotein-coding
Map location13q14.2
Pascal p-value0.336
Sherlock p-value0.971
Fetal beta0.114
DMG1 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
Cortex
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg244291591348669391MED45.21E-9-0.0112.92E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4941618chr1348517288MED4290790cis
rs7996581chr1348636963MED4290796.294E-4cis
rs7332363chr1348666760MED4290790.01cis
rs7332994chr1348674134MED4290791.316E-4cis
rs1410116chr1348685915MED4290795.356E-4cis
rs7326381chr1348696213MED4290796.016E-4cis
rs7317685chr1348715752MED4290790.02cis
rs4941618chr1348517288MED4290790.19trans
rs7996581chr1348636963MED4290790.05trans
rs7332994chr1348674134MED4290790.01trans
rs1410116chr1348685915MED4290790.04trans
rs7326381chr1348696213MED4290790.05trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIDA12218053 
GO:0003712transcription cofactor activityIDA12218053 
GO:0005515protein bindingIPI17438371 
GO:0016455RNA polymerase II transcription mediator activityIDA10882111 
GO:0016563transcription activator activityIDA10198638 
GO:0030374ligand-dependent nuclear receptor transcription coactivator activityNAS10235266 
GO:0042809vitamin D receptor bindingNAS10235266 
GO:0046966thyroid hormone receptor bindingIDA10198638 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006367transcription initiation from RNA polymerase II promoterIDA12218053 
GO:0006350transcriptionIEA-
GO:0030521androgen receptor signaling pathwayIDA12218053 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000119mediator complexIDA10882111 
GO:0005634nucleusIDA10235267 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2M1AP50 | CLAPM1 | mu2adaptor-related protein complex 2, mu 1 subunitTwo-hybridBioGRID16189514 
MCRS1ICP22BP | INO80Q | MCRS2 | MSP58 | P78microspherule protein 1Two-hybridBioGRID16189514 
MED10L6 | MGC5309 | NUT2 | TRG20mediator complex subunit 10Affinity Capture-MS
Affinity Capture-Western
BioGRID14638676 |15175163 
MED19DT2P1G7 | LCMR1mediator complex subunit 19Affinity Capture-MS
Affinity Capture-Western
BioGRID14638676 |15175163 
MED25ACID1 | ARC92 | DKFZp434K0512 | MGC70671 | P78 | PTOV2 | TCBAP0758mediator complex subunit 25Affinity Capture-Western
Reconstituted Complex
BioGRID14638676 
MED26CRSP7 | CRSP70mediator complex subunit 26Affinity Capture-MSBioGRID15175163 
MED281500003D12Rik | DKFZp434N185 | EG1 | magicinmediator complex subunit 28Affinity Capture-MSBioGRID15175163 
MED29DKFZp434H247 | IXLmediator complex subunit 29-HPRD14576168 
MED29DKFZp434H247 | IXLmediator complex subunit 29Affinity Capture-MS
Affinity Capture-Western
BioGRID14638676 |15175163 
MED30MGC9890 | THRAP6 | TRAP25mediator complex subunit 30TRAP36 interacts with TRAP25. This interaction was modelled on a demonstrated interaction between human TRAP36 and mouse TRAP25.BIND12584197 
MED30MGC9890 | THRAP6 | TRAP25mediator complex subunit 30Reconstituted ComplexBioGRID12584197 
MED9FLJ10193 | MED25 | MGC138234mediator complex subunit 9Affinity Capture-MSBioGRID15175163 
MED9FLJ10193 | MED25 | MGC138234mediator complex subunit 9-HPRD14638676 
TNFAIP8GG2-1 | MDC-3.13 | SCC-S2 | SCCS2tumor necrosis factor, alpha-induced protein 8Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 10472All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352181All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168115All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7253All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165106All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 12778All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX5 DN 85All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER DN 4134All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336211All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway