Gene Page: RACGAP1

Summary ?
GeneID29127
SymbolRACGAP1
SynonymsCYK4|HsCYK-4|ID-GAP|MgcRacGAP
DescriptionRac GTPase activating protein 1
ReferenceMIM:604980|HGNC:HGNC:9804|Ensembl:ENSG00000161800|HPRD:05402|Vega:OTTHUMG00000169811
Gene typeprotein-coding
Map location12q13.12
Pascal p-value0.055
Sherlock p-value0.625
Fetal beta1.194
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs981110chr1933022454RACGAP1291270.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005096GTPase activator activityIDA10979956 
GO:0008270zinc ion bindingIEA-
GO:0008022protein C-terminus bindingIPI11278976 
GO:0019992diacylglycerol bindingIEA-
GO:0043014alpha-tubulin bindingIDA11085985 
GO:0043015gamma-tubulin bindingIDA11085985 
GO:0046872metal ion bindingIEA-
GO:0048487beta-tubulin bindingIDA11085985 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007405neuroblast proliferationIEAneuron (GO term level: 8)-
GO:0007405neuroblast proliferationISSneuron (GO term level: 8)-
GO:0000910cytokinesisIDA11085985 
GO:0000915cytokinesis, contractile ring formationIMP16129829 
GO:0007242intracellular signaling cascadeIEA-
GO:0007283spermatogenesisIEP12590651 
GO:0007165signal transductionIEA-
GO:0007049cell cycleIEA-
GO:0007108cytokinesis, initiation of separationIMP16129829 
GO:0008272sulfate transportIDA11278976 
GO:0009790embryonic developmentIEA-
GO:0009790embryonic developmentISS-
GO:0006811ion transportIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001669acrosomeIEA-
GO:0005819spindleIEA-
GO:0005874microtubuleIEA-
GO:0005622intracellularIEA-
GO:0005634nucleusIDA11085985 
GO:0005737cytoplasmIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AURKBAIK2 | AIM-1 | AIM1 | ARK2 | AurB | IPL1 | STK12 | STK5aurora kinase B-HPRD,BioGRID12689593 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-MSBioGRID12577067 
KIF23CHO1 | KNSL5 | MKLP-1 | MKLP1kinesin family member 23-HPRD11942621 
MAP3K10MLK2 | MSTmitogen-activated protein kinase kinase kinase 10-HPRD9427749 
MAP3K4FLJ42439 | KIAA0213 | MAPKKK4 | MEKK4 | MTK1 | PRO0412mitogen-activated protein kinase kinase kinase 4-HPRD9079650 
PRSS23MGC5107 | SIG13 | SPUVE | ZSIG13protease, serine, 23Two-hybridBioGRID16169070 
RND2ARHN | RHO7 | RhoNRho family GTPase 2-HPRD,BioGRID12590651 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
SH3RF1FLJ21602 | KIAA1494 | POSH | RNF142 | SH3MD2SH3 domain containing ring finger 1-HPRD9482736 
SLC26A8FLJ32714 | TAT1solute carrier family 26, member 8-HPRD,BioGRID11278976 
TUBA4AFLJ30169 | H2-ALPHA | TUBA1tubulin, alpha 4a-HPRD11942621 
TUBG1TUBG | TUBGCP1tubulin, gamma 1-HPRD11942621 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID10748082 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideAffinity Capture-MSBioGRID17353931 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideAffinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
SIG CHEMOTAXIS 4537All SZGR 2.0 genes in this pathway
PID AURORA B PATHWAY 3924All SZGR 2.0 genes in this pathway
PID CDC42 REG PATHWAY 3022All SZGR 2.0 genes in this pathway
PID RAC1 REG PATHWAY 3825All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY 5437All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 11381All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION 9161All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132101All SZGR 2.0 genes in this pathway
REACTOME KINESINS 2419All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285181All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294178All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 15184All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP 7350All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310188All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430232All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT UP 8745All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181101All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN 8749All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214134All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378231All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
NADERI BREAST CANCER PROGNOSIS UP 5026All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228137All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A DN 9061All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS DN 5733All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165107All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147101All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181107All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS 9758All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER 14073All SZGR 2.0 genes in this pathway
OHASHI AURKB TARGETS 106All SZGR 2.0 genes in this pathway
FURUKAWA DUSP6 TARGETS PCI35 DN 7440All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209139All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 ONLY DN 4430All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION 14780All SZGR 2.0 genes in this pathway
GEORGES CELL CYCLE MIR192 TARGETS 6246All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE UP 8054All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE UP 8649All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185111All SZGR 2.0 genes in this pathway
YU MYC TARGETS UP 4226All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI DN 7345All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR UP 4520All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN 234137All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN 172107All SZGR 2.0 genes in this pathway
GREENBAUM E2A TARGETS UP 3318All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203135All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3 10164All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR 4330All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250168All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING DN 4226All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP 13484All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS UP 11271All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN 10864All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294199All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN 210128All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346192All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238145All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277166All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178108All SZGR 2.0 genes in this pathway
WANG RECURRENT LIVER CANCER UP 2013All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251151All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277172All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207143All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP 16286All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335193All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE LITERATURE 4425All SZGR 2.0 genes in this pathway
WU APOPTOSIS BY CDKN1A VIA TP53 5531All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN 10367All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 13596All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 6HR 8549All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR 12873All SZGR 2.0 genes in this pathway