Gene Page: CXCL2

Summary ?
GeneID2920
SymbolCXCL2
SynonymsCINC-2a|GRO2|GROb|MGSA-b|MIP-2a|MIP2|MIP2A|SCYB2
DescriptionC-X-C motif chemokine ligand 2
ReferenceMIM:139110|HGNC:HGNC:4603|Ensembl:ENSG00000081041|HPRD:00741|Vega:OTTHUMG00000160865
Gene typeprotein-coding
Map location4q21
Pascal p-value0.935
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg02741554474965278CXCL21.17E-8-0.0134.85E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10915489chr14321466CXCL229201.19E-6trans
rs17105629chr149799320CXCL229200.19trans
rs473019chr172296394CXCL229200.03trans
rs2997198chr180760865CXCL229200.02trans
rs1342707chr1147264296CXCL229205.263E-5trans
rs12076447chr1159552549CXCL229200.08trans
rs529346chr1160743808CXCL229200.12trans
rs10494571chr1183930700CXCL229200.07trans
rs2907143chr1243147434CXCL229203.921E-4trans
rs6760426chr266175535CXCL229200.03trans
rs17546660chr266218021CXCL229200.01trans
rs17541094chr266266798CXCL229200.02trans
rs9677627chr280471983CXCL229200.08trans
snp_a-21983630CXCL229200.11trans
rs16865891chr2225235339CXCL229200.06trans
rs4676558chr340084233CXCL229200.1trans
snp_a-19748900CXCL229200.01trans
rs16847252chr3163481290CXCL229202.108E-4trans
rs4256179chr3169628328CXCL229200.02trans
rs9870311chr3169641061CXCL229200.02trans
rs16846456chr3172757337CXCL229200trans
rs591585chr443424979CXCL229200trans
rs17052594chr4167698562CXCL229200.11trans
rs31304chr552942082CXCL229200.02trans
rs7726346chr580229097CXCL229200.17trans
rs10515260chr597076547CXCL229202.588E-5trans
rs10515267chr5100128201CXCL229200.07trans
rs1550363chr5124480528CXCL229200.16trans
rs6863508chr5159131795CXCL229200.13trans
rs6920921chr68884160CXCL229200.18trans
rs10498827chr665470694CXCL229200.19trans
rs1587434chr666615354CXCL229200.04trans
rs16869716chr671743471CXCL229200.07trans
rs2072161chr7105662460CXCL229200trans
rs4726747chr7144883187CXCL229200.11trans
rs9325708chr812402940CXCL229200.02trans
rs1451681chr840491890CXCL229200.19trans
rs13282254chr8126625316CXCL229200.06trans
rs16909867chr925899226CXCL229200.01trans
rs2082711chr983109430CXCL229200.01trans
rs1507903chr9119185777CXCL229200.05trans
rs3802522chr1028341865CXCL229201.085E-13trans
rs10508730chr1028403391CXCL229201.085E-13trans
rs1913524chr1050227869CXCL229200.16trans
rs2254632chr1050236578CXCL229200.12trans
rs2466750chr1050240164CXCL229200.01trans
rs1240385chr1088727329CXCL229200.02trans
rs7089703chr10119182182CXCL229200.01trans
rs17096254chr10119207026CXCL229200.06trans
rs17101184chr10122712943CXCL229200.07trans
rs10743139chr1110425326CXCL229208.9E-7trans
rs936368chr1180971140CXCL229200.18trans
rs17139249chr11130155705CXCL229200.14trans
rs2512874chr11131461291CXCL229208.082E-4trans
rs11107750chr1295241256CXCL229200.12trans
rs7304048chr1295292947CXCL229200.12trans
rs4762419chr1295771835CXCL229200trans
rs1566556chr12101918977CXCL229200.1trans
rs9645995chr1347246048CXCL229200.13trans
rs9598109chr1360878618CXCL229200.06trans
rs8028951chr1527187231CXCL229200.01trans
rs16968806chr1539622447CXCL229200.19trans
rs2219618chr1554109136CXCL229200.18trans
rs17271500chr1562428608CXCL229200.17trans
rs12445121chr1673542119CXCL229200.2trans
rs16959765chr1683237750CXCL229200.18trans
rs4783332chr1683238773CXCL229200.18trans
rs4303487chr1690033254CXCL229200.08trans
rs2448755chr1865344801CXCL229200.08trans
rs7228544chr1875188991CXCL229200.15trans
rs10425739chr1929582202CXCL229200trans
snp_a-21385750CXCL229200.06trans
rs6076051chr2023306825CXCL229200.06trans
rs6076060chr2023345068CXCL229200trans
rs2148213chr2054798599CXCL229200.01trans
rs17342476chrX102243644CXCL229205.439E-5trans
rs17342483chrX102250155CXCL229206.097E-4trans
rs17342504chrX102272107CXCL229205.439E-5trans
snp_a-21388510CXCL229205.439E-5trans
snp_a-20599280CXCL229205.439E-5trans
rs12393459chrX118215731CXCL229200.12trans
rs3813932chrX118220719CXCL229200.12trans
rs6634857chrX131111922CXCL229200.04trans
rs5953544chrX140038593CXCL229200.15trans
rs7065915chrX140038729CXCL229200.15trans
rs5966028chrX145163390CXCL229200.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ERAL10.900.87
TCF250.890.86
ATG4B0.890.87
CPT1C0.890.84
AAMP0.890.86
C11orf490.880.85
MARS0.880.85
TRAP10.880.85
TMUB20.880.85
RABGGTA0.870.84
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.8-0.78-0.71
AF347015.21-0.78-0.74
AF347015.27-0.77-0.73
MT-CO2-0.76-0.69
AF347015.31-0.76-0.69
AF347015.2-0.75-0.70
MT-CYB-0.75-0.68
AF347015.33-0.74-0.68
AF347015.15-0.73-0.67
MT-ATP8-0.72-0.75

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 6247All SZGR 2.0 genes in this pathway
ST GRANULE CELL SURVIVAL PATHWAY 2723All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES 5727All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485293All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460312All SZGR 2.0 genes in this pathway
NEWMAN ERCC6 TARGETS UP 2618All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306188All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 14290All SZGR 2.0 genes in this pathway
PEPPER CHRONIC LYMPHOCYTIC LEUKEMIA UP 3328All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242165All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281186All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE UP 5236All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544308All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA UP 14175All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS CML DIVIDING UP 2313All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP 5733All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN 9557All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP 6647All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP 6446All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
MUELLER METHYLATED IN GLIOBLASTOMA 4022All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 12792All SZGR 2.0 genes in this pathway
RASHI NFKB1 TARGETS 1918All SZGR 2.0 genes in this pathway
OXFORD RALA TARGETS UP 97All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380213All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS DN 3217All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156106All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 ONLY UP 3318All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 HELA 6947All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 60 MCF10A 3924All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 40 MCF10A 3221All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169102All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 3 DN 5932All SZGR 2.0 genes in this pathway
ONDER CDH1 SIGNALING VIA CTNNB1 8358All SZGR 2.0 genes in this pathway
ZUCCHI METASTASIS DN 4429All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 14591All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182116All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 8356All SZGR 2.0 genes in this pathway
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN 7347All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 8567All SZGR 2.0 genes in this pathway
HEDVAT ELF4 TARGETS UP 128All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 DN 7748All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS UP 5234All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 12890All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP 7752All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION 2 5334All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 6M 7447All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 5141All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244151All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 3M 5936All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222139All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 10668All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP 12375All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 14896All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 8152All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G2 3018All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261166All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 9071All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 9268All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP 5641All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 10963All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR REJECTION UP 5632All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS DN 3621All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 7355All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
CUI GLUCOSE DEPRIVATION 6044All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
FERRARI RESPONSE TO FENRETINIDE UP 2216All SZGR 2.0 genes in this pathway
SPIRA SMOKERS LUNG CANCER UP 3824All SZGR 2.0 genes in this pathway
SOUCEK MYC TARGETS 86All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP 7756All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 6752All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION UP 6042All SZGR 2.0 genes in this pathway
SCHOEN NFKB SIGNALING 3426All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 4430All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN 3726All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
TIAN TNF SIGNALING VIA NFKB 2821All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G28 2011All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP 6144All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
WINZEN DEGRADED VIA KHSRP 10070All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289188All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway
PHONG TNF TARGETS UP 6343All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160106All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 12881All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289184All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 11068All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 8654All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222159All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway