SZGR2

Summary ?

GeneID	2960
Symbol	GTF2E1
Synonyms	FE\|TF2E1\|TFIIE-A
Description	general transcription factor IIE subunit 1
Reference	MIM:189962\|HGNC:HGNC:4650\|Ensembl:ENSG00000153767\|HPRD:01799\|Vega:OTTHUMG00000159667
Gene type	protein-coding
Map location	3q21-q24
Pascal p-value	0.599
DEG p-value	DEG:Zhao_2015:p=5.81e-04:q=0.0926
Fetal beta	0.111

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DEG:Zhao_2015	RNA Sequencing analysis	Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
PPM1L	0.91	0.92
GPD1L	0.90	0.91
MMP16	0.87	0.89
C1orf96	0.87	0.92
BMPR2	0.86	0.92
NLGN1	0.86	0.90
LASS6	0.86	0.89
LRRTM2	0.85	0.89
DNM3	0.85	0.89
PDE4D	0.85	0.89

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SERPINB6	-0.63	-0.71
C19orf36	-0.60	-0.69
HSD17B14	-0.60	-0.73
FXYD1	-0.59	-0.77
FAH	-0.59	-0.69
HEPN1	-0.58	-0.70
TREX1	-0.58	-0.70
TTYH1	-0.58	-0.66
ROM1	-0.57	-0.72
TLCD1	-0.57	-0.74

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AES	AES-1 \| AES-2 \| ESP1 \| GRG \| GRG5 \| TLE5	amino-terminal enhancer of split	-	HPRD,BioGRID	11416139
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Co-purification	BioGRID	9159119
ERCC3	BTF2 \| GTF2H \| RAD25 \| TFIIH \| XPB	excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)	-	HPRD,BioGRID	7926747 \|8152490
GTF2A1	MGC129969 \| MGC129970 \| TF2A1 \| TFIIA	general transcription factor IIA, 1, 19/37kDa	-	HPRD,BioGRID	11509574
GTF2A2	HsT18745 \| TF2A2 \| TFIIA	general transcription factor IIA, 2, 12kDa	-	HPRD	11509574
GTF2B	TF2B \| TFIIB	general transcription factor IIB	Co-purification Reconstituted Complex	BioGRID	9159119
GTF2E2	FE \| TF2E2 \| TFIIE-B	general transcription factor IIE, polypeptide 2, beta 34kDa	-	HPRD,BioGRID	9677423 \|11113176 \|12665589
GTF2F1	BTF4 \| RAP74 \| TF2F1 \| TFIIF	general transcription factor IIF, polypeptide 1, 74kDa	Co-purification Reconstituted Complex	BioGRID	7926747 \|9159119
GTF2F2	BTF4 \| RAP30 \| TF2F2 \| TFIIF	general transcription factor IIF, polypeptide 2, 30kDa	-	HPRD	11113176
GTF2F2	BTF4 \| RAP30 \| TF2F2 \| TFIIF	general transcription factor IIF, polypeptide 2, 30kDa	Reconstituted Complex	BioGRID	7926747
GTF2H1	BTF2 \| TFB1 \| TFIIH	general transcription factor IIH, polypeptide 1, 62kDa	-	HPRD	11113176
GTF2H4	TFB2 \| TFIIH	general transcription factor IIH, polypeptide 4, 52kDa	Co-purification Reconstituted Complex	BioGRID	9159119
GTF2H4	TFB2 \| TFIIH	general transcription factor IIH, polypeptide 4, 52kDa	-	HPRD	11113176
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	Reconstituted Complex	BioGRID	9271120
MED21	SRB7 \| SURB7	mediator complex subunit 21	Affinity Capture-Western Co-purification	BioGRID	9159119
POLR2A	MGC75453 \| POLR2 \| POLRA \| RPB1 \| RPBh1 \| RPO2 \| RPOL2 \| RpIILS \| hRPB220 \| hsRPB1	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	Co-purification Reconstituted Complex	BioGRID	7926747 \|9159119
SND1	TDRD11 \| p100	staphylococcal nuclease and tudor domain containing 1	-	HPRD,BioGRID	7651391
TAF1	BA2R \| CCG1 \| CCGS \| DYT3 \| KAT4 \| N-TAF1 \| NSCL2 \| OF \| P250 \| TAF2A \| TAFII250	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	Reconstituted Complex	BioGRID	7926747
TAF11	MGC:15243 \| PRO2134 \| TAF2I \| TAFII28	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa	Co-purification Reconstituted Complex	BioGRID	9159119
TAF6	DKFZp781E21155 \| MGC:8964 \| TAF2E \| TAFII70 \| TAFII80 \| TAFII85	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	-	HPRD,BioGRID	7667268
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	-	HPRD	11113176
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	Co-purification Reconstituted Complex	BioGRID	7926747 \|9159119
TCEA1	GTF2S \| SII \| TCEA \| TF2S \| TFIIS	transcription elongation factor A (SII), 1	-	HPRD,BioGRID	9305922
TRIM24	PTC6 \| RNF82 \| TF1A \| TIF1 \| TIF1A \| TIF1ALPHA \| hTIF1	tripartite motif-containing 24	-	HPRD,BioGRID	9632676

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG BASAL TRANSCRIPTION FACTORS	36	24	All SZGR 2.0 genes in this pathway
BIOCARTA CARM ER PATHWAY	35	27	All SZGR 2.0 genes in this pathway
BIOCARTA RARRXR PATHWAY	15	9	All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION	105	54	All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	41	21	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION	210	127	All SZGR 2.0 genes in this pathway
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	61	32	All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION	207	122	All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE	125	69	All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE	104	61	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A UP	77	49	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
SHIPP DLBCL CURED VS FATAL DN	45	30	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D2	41	30	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN	220	147	All SZGR 2.0 genes in this pathway
KAMMINGA SENESCENCE	41	26	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN	222	147	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN	254	158	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN	448	282	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Gene Page: GTF2E1