Gene Page: PACSIN3
Summary ?
| GeneID | 29763 |
| Symbol | PACSIN3 |
| Synonyms | SDPIII |
| Description | protein kinase C and casein kinase substrate in neurons 3 |
| Reference | MIM:606513|HGNC:HGNC:8572|Ensembl:ENSG00000165912|HPRD:05937|Vega:OTTHUMG00000166870 |
| Gene type | protein-coding |
| Map location | 11p11.2 |
| Pascal p-value | 0.002 |
| eGene | Cerebellum Myers' cis & trans |
| Support | G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10994209 | chr10 | 61877705 | PACSIN3 | 29763 | 0.14 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ASAP1 | AMAP1 | CENTB4 | DDEF1 | KIAA1249 | PAG2 | PAP | ZG14P | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | DDEF1 (AMAP1) interacts with PACSIN3. | BIND | 15719014 |
| ASAP2 | AMAP2 | CENTB3 | DDEF2 | FLJ42910 | KIAA0400 | PAG3 | PAP | Pap-alpha | SHAG1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | DDEF2 (AMAP2) interacts with PACSIN3. | BIND | 15719014 |
| DNM1 | DNM | dynamin 1 | - | HPRD,BioGRID | 11082044 |
| NOL3 | ARC | CARD2 | MYC | MYP | NOP | NOP30 | nucleolar protein 3 (apoptosis repressor with CARD domain) | Affinity Capture-MS | BioGRID | 17353931 |
| PACSIN1 | KIAA1379 | SDPI | protein kinase C and casein kinase substrate in neurons 1 | - | HPRD,BioGRID | 11082044 |
| PACSIN2 | SDPII | protein kinase C and casein kinase substrate in neurons 2 | - | HPRD,BioGRID | 11082044 |
| PACSIN3 | SDPIII | protein kinase C and casein kinase substrate in neurons 3 | - | HPRD | 11179684 |
| PACSIN3 | SDPIII | protein kinase C and casein kinase substrate in neurons 3 | Reconstituted Complex Two-hybrid | BioGRID | 11082044 |
| PYGM | - | phosphorylase, glycogen, muscle | Affinity Capture-MS | BioGRID | 17353931 |
| RPL23A | FLJ27455 | MDA20 | ribosomal protein L23a | Affinity Capture-MS | BioGRID | 17353931 |
| SYNJ1 | INPP5G | synaptojanin 1 | Reconstituted Complex | BioGRID | 11082044 |
| WASL | DKFZp779G0847 | MGC48327 | N-WASP | NWASP | Wiskott-Aldrich syndrome-like | - | HPRD,BioGRID | 11082044 |
| hCG_1983332 | LOC441246 | hCG1983332 | Affinity Capture-MS | BioGRID | 17353931 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KIM RESPONSE TO TSA AND DECITABINE DN | 13 | 10 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL DN | 186 | 107 | All SZGR 2.0 genes in this pathway |
| ROVERSI GLIOMA COPY NUMBER UP | 100 | 75 | All SZGR 2.0 genes in this pathway |
| AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 8G | 95 | 62 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING | 510 | 309 | All SZGR 2.0 genes in this pathway |
| VANTVEER BREAST CANCER BRCA1 UP | 36 | 18 | All SZGR 2.0 genes in this pathway |
| MELLMAN TUT1 TARGETS DN | 47 | 29 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP C | 92 | 60 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |