Summary ?
GeneID29785
SymbolCYP2S1
SynonymsCYPIIS1
Descriptioncytochrome P450 family 2 subfamily S member 1
ReferenceMIM:611529|HGNC:HGNC:15654|Ensembl:ENSG00000167600|HPRD:07481|Vega:OTTHUMG00000182721
Gene typeprotein-coding
Map location19q13.1
Pascal p-value0.061
Fetal beta-0.885
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
ExpressionMeta-analysis of gene expressionP value: 1.682 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg255202491941700269CYP2S17.34E-50.2450.025DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0020037heme bindingIEA-
GO:0009055electron carrier activityIEA-
GO:0046872metal ion bindingIEA-
GO:0050381unspecific monooxygenase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0055114oxidation reductionNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIEA-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumNAS-
GO:0016020membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 7044All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 13991All SZGR 2.0 genes in this pathway
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 5134All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 7050All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7 9052All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K27ME3 7959All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
QI HYPOXIA 14096All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS UP 11265All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289188All SZGR 2.0 genes in this pathway