Summary ?
GeneID2981
SymbolGUCA2B
SynonymsGCAP-II|UGN
Descriptionguanylate cyclase activator 2B
ReferenceMIM:601271|HGNC:HGNC:4683|Ensembl:ENSG00000044012|HPRD:03170|Vega:OTTHUMG00000007024
Gene typeprotein-coding
Map location1p34-p33
Pascal p-value0.561
Fetal beta0.122
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg11837471142618225GUCA2B4.225E-4-0.3070.045DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10994209chr1061877705GUCA2B29810.17trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TAS2R480.410.28
TPH10.400.31
KLRA10.390.31
RBM440.390.28
ANKRD360.380.34
PDXDC20.380.35
ZNF3820.370.23
AC004932.20.370.29
PDE6C0.360.28
AC131160.20.360.21
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CCDC3-0.27-0.29
KCNJ8-0.26-0.24
NBL1-0.25-0.29
OLFM1-0.24-0.26
EFHD2-0.24-0.27
BSG-0.24-0.27
ADAP1-0.24-0.29
ADCY2-0.24-0.25
FKBP8-0.24-0.28
NR1H2-0.24-0.24

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
SABATES COLORECTAL ADENOMA DN 291176All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
BAUS TFF2 TARGETS UP 3222All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 10772All SZGR 2.0 genes in this pathway