Gene Page: PDZRN4
Summary ?
| GeneID | 29951 |
| Symbol | PDZRN4 |
| Synonyms | LNX4|SAMCAP3L |
| Description | PDZ domain containing ring finger 4 |
| Reference | MIM:609730|HGNC:HGNC:30552|Ensembl:ENSG00000165966|HPRD:15116|Vega:OTTHUMG00000169364 |
| Gene type | protein-coding |
| Map location | 12q12 |
| Pascal p-value | 0.073 |
| Sherlock p-value | 0.914 |
| eGene | Cortex Nucleus accumbens basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| CV:PheWAS | Phenome-wide association studies (PheWAS) | 157 SNPs associated with schizophrenia | 1 |
Section I. Genetics and epigenetics annotation
CV:PheWAS
| SNP ID | Chromosome | Position | Allele | P | Function | Gene | Up/Down Distance |
|---|---|---|---|---|---|---|---|
| rs1458175 | 12 | 41965861 | null | 0.6855 | PDZRN4 | null |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1350431 | chr12 | 41819314 | PDZRN4 | 29951 | 0 | cis | ||
| rs2730830 | chr12 | 41829145 | PDZRN4 | 29951 | 0 | cis | ||
| rs2733282 | chr12 | 41829237 | PDZRN4 | 29951 | 0 | cis | ||
| rs2730819 | chr12 | 41839413 | PDZRN4 | 29951 | 0.01 | cis | ||
| rs2608692 | chr12 | 41851916 | PDZRN4 | 29951 | 0 | cis | ||
| rs2250009 | chr12 | 41859168 | PDZRN4 | 29951 | 0 | cis | ||
| rs2733269 | chr12 | 41866716 | PDZRN4 | 29951 | 0 | cis | ||
| rs2608717 | chr12 | 41908986 | PDZRN4 | 29951 | 0.16 | cis | ||
| rs285559 | chr12 | 41929812 | PDZRN4 | 29951 | 0.09 | cis | ||
| rs285595 | chr12 | 41940532 | PDZRN4 | 29951 | 0.08 | cis | ||
| rs287087 | chr12 | 41943476 | PDZRN4 | 29951 | 0.16 | cis | ||
| rs285584 | chr12 | 41946538 | PDZRN4 | 29951 | 0.05 | cis | ||
| rs970970 | chr12 | 41970163 | PDZRN4 | 29951 | 0.03 | cis | ||
| rs12367934 | chr12 | 41978921 | PDZRN4 | 29951 | 0.02 | cis | ||
| rs287031 | chr12 | 41985431 | PDZRN4 | 29951 | 0.03 | cis | ||
| rs1350431 | chr12 | 41819314 | PDZRN4 | 29951 | 0.12 | trans | ||
| rs2730830 | chr12 | 41829145 | PDZRN4 | 29951 | 0.11 | trans | ||
| rs2733282 | chr12 | 41829237 | PDZRN4 | 29951 | 0.07 | trans | ||
| rs2608692 | chr12 | 41851916 | PDZRN4 | 29951 | 0.1 | trans | ||
| rs2250009 | chr12 | 41859168 | PDZRN4 | 29951 | 0.17 | trans | ||
| rs2733269 | chr12 | 41866716 | PDZRN4 | 29951 | 0.13 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CHEBOTAEV GR TARGETS DN | 120 | 73 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA CD2 UP | 45 | 32 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER RACE UP | 299 | 167 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA MF DN | 41 | 28 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |