Gene Page: DMGDH
Summary ?
| GeneID | 29958 |
| Symbol | DMGDH |
| Synonyms | DMGDHD|ME2GLYDH |
| Description | dimethylglycine dehydrogenase |
| Reference | MIM:605849|HGNC:HGNC:24475|Ensembl:ENSG00000132837|HPRD:05789|Vega:OTTHUMG00000108159 |
| Gene type | protein-coding |
| Map location | 5q14.1 |
| Pascal p-value | 0.047 |
| eGene | Caudate basal ganglia Frontal Cortex BA9 Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10994209 | chr10 | 61877705 | DMGDH | 29958 | 0.12 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PLA2G4B | 0.74 | 0.68 |
| FGF17 | 0.73 | 0.63 |
| AC174470.2 | 0.72 | 0.60 |
| AC011511.1 | 0.72 | 0.63 |
| TFAP2E | 0.71 | 0.61 |
| LENG8 | 0.71 | 0.65 |
| JMJD7-PLA2G4B | 0.71 | 0.61 |
| CCDC57 | 0.71 | 0.65 |
| NEIL1 | 0.70 | 0.63 |
| GNB3 | 0.70 | 0.66 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ITM2A | -0.37 | -0.40 |
| TM4SF18 | -0.35 | -0.35 |
| ELTD1 | -0.34 | -0.29 |
| GNG11 | -0.31 | -0.40 |
| GIMAP4 | -0.31 | -0.35 |
| MYL12A | -0.30 | -0.29 |
| GIMAP2 | -0.30 | -0.31 |
| ABCG2 | -0.30 | -0.30 |
| AF347015.31 | -0.30 | -0.24 |
| NMI | -0.30 | -0.32 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYCINE SERINE AND THREONINE METABOLISM | 31 | 26 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM4 | 261 | 153 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA CD1 VS CD2 UP | 66 | 47 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER | 49 | 29 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K27ME3 | 269 | 159 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |