SZGR2

Summary ?

GeneID	30011
Symbol	SH3KBP1
Synonyms	CD2BP3\|CIN85\|GIG10\|HSB-1\|HSB1\|MIG18
Description	SH3-domain kinase binding protein 1
Reference	MIM:300374\|HGNC:HGNC:13867\|Ensembl:ENSG00000147010\|HPRD:02301\|Vega:OTTHUMG00000021227
Gene type	protein-coding
Map location	Xp22.1-p21.3
Sherlock p-value	0.057
Fetal beta	-0.887
Support	G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanPSD G2Cdb.humanPSP Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.2206

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003674	molecular_function	ND		-
GO:0005515	protein binding	IPI		12029088
GO:0017124	SH3 domain binding	IEA		-
GO:0016301	kinase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007267	cell-cell signaling	NAS		10679202
GO:0006915	apoptosis	IEA		-
GO:0006897	endocytosis	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0019717	synaptosome	IEA	Synap, Brain (GO term level: 7)	-
GO:0045202	synapse	IEA	neuron, Synap, Neurotransmitter, Glial (GO term level: 2)	-
GO:0005829	cytosol	EXP		10567358 \|11894095 \|12218189 \|15962011
GO:0005856	cytoskeleton	IEA		-
GO:0005634	nucleus	IDA		18029348
GO:0005730	nucleolus	IDA		18029348
GO:0005737	cytoplasm	IEA		-
GO:0005886	plasma membrane	EXP		16407834
GO:0030054	cell junction	IEA		-
GO:0031410	cytoplasmic vesicle	IEA		-
GO:0030659	cytoplasmic vesicle membrane	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABI2	ABI-2 \| ABI2B \| AIP-1 \| AblBP3 \| SSH3BP2 \| argBPIA \| argBPIB	abl interactor 2	-	HPRD,BioGRID	10858458
ARHGAP27	CAMGAP1 \| FLJ43547 \| MGC120624	Rho GTPase activating protein 27	-	HPRD,BioGRID	15147912
ASAP1	AMAP1 \| CENTB4 \| DDEF1 \| KIAA1249 \| PAG2 \| PAP \| ZG14P	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	DDEF1 (AMAP1) interacts with SH3KBP1 (CIN85).	BIND	15719014
ASAP2	AMAP2 \| CENTB3 \| DDEF2 \| FLJ42910 \| KIAA0400 \| PAG3 \| PAP \| Pap-alpha \| SHAG1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	DDEF2 (AMAP2) interacts with SH3KBP1 (CIN85).	BIND	15719014
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	Affinity Capture-Western	BioGRID	11071869
BLNK	BASH \| BLNK-S \| LY57 \| MGC111051 \| SLP-65 \| SLP65	B-cell linker	-	HPRD,BioGRID	11071869
CAPZA1	CAPPA1 \| CAPZ \| CAZ1	capping protein (actin filament) muscle Z-line, alpha 1	-	HPRD	12690097
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	11894095
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	CIN85 interacts with Cbl.	BIND	11894095
CBLB	DKFZp686J10223 \| DKFZp779A0729 \| DKFZp779F1443 \| FLJ36865 \| FLJ41152 \| Nbla00127 \| RNF56	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	-	HPRD,BioGRID	12218189
CD2	SRBC \| T11	CD2 molecule	-	HPRD	12690097
CD2	SRBC \| T11	CD2 molecule	-	HPRD,BioGRID	9857189 \|12690097\|12690097
CD2	SRBC \| T11	CD2 molecule	SETA interacts with CD2. This interaction was modelled on a demonstrated interaction between rat SETA and human CD2.	BIND	11152963
CLYBL	CLB \| bA134O15.1	citrate lyase beta like	Affinity Capture-Western	BioGRID	11894096
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	Affinity Capture-Western	BioGRID	11071869
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Affinity Capture-Western	BioGRID	11894095 \|12177062
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	9507006\|11152963
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	SETA interacts with Grb2. This interaction was modelled on a demonstrated interaction between rat SETA and human Grb2	BIND	11152963
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Reconstituted Complex	BioGRID	10921882 \|11152963
KIT	C-Kit \| CD117 \| PBT \| SCFR	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Affinity Capture-Western	BioGRID	12177062
MET	AUTS9 \| HGFR \| RCCP2 \| c-Met	met proto-oncogene (hepatocyte growth factor receptor)	-	HPRD,BioGRID	11894096
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	neural precursor cell expressed, developmentally down-regulated 4	-	HPRD,BioGRID	12218189
PAK2	PAK65 \| PAKgamma	p21 protein (Cdc42/Rac)-activated kinase 2	-	HPRD,BioGRID	12829691
PDCD6	ALG-2 \| FLJ46208 \| MGC111017 \| MGC119050 \| MGC9123 \| PEF1B	programmed cell death 6	-	HPRD,BioGRID	10858458
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD,BioGRID	12177062
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD,BioGRID	10921882
SH3GL1	CNSA1 \| EEN \| MGC111371 \| SH3D2B \| SH3P8	SH3-domain GRB2-like 1	Endophilin A2 interacts with CIN85. This interaction was modeled on a demonstrated interaction between endophilin A2 from an unspecified species and human CIN85.	BIND	11894096
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	-	HPRD,BioGRID	12218189
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	CIN85 interacts with endophilin A1. This interaction was modeled on a demonstrated interaction between human CIN85 and mouse endophilin A1.	BIND	11894095
SH3GL3	CNSA3 \| EEN-2B-L3 \| EEN-B2 \| HsT19371 \| SH3D2C \| SH3P13	SH3-domain GRB2-like 3	Endophilin A3 interacts with CIN85.	BIND	11894096
SH3GL3	CNSA3 \| EEN-2B-L3 \| EEN-B2 \| HsT19371 \| SH3D2C \| SH3P13	SH3-domain GRB2-like 3	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	11894096
SH3GLB1	Bif-1 \| CGI-61 \| KIAA0491 \| dJ612B15.2	SH3-domain GRB2-like endophilin B1	Reconstituted Complex	BioGRID	11894096
SH3GLB2	KIAA1848 \| PP6569 \| PP9455	SH3-domain GRB2-like endophilin B2	Reconstituted Complex Two-hybrid	BioGRID	11894095 \|11894096
SH3KBP1	CIN85 \| GIG10 \| MIG18	SH3-domain kinase binding protein 1	Affinity Capture-Western Two-hybrid	BioGRID	11071869 \|11894095
SHKBP1	PP203 \| Sb1	SH3KBP1 binding protein 1	-	HPRD,BioGRID	11152963
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	-	HPRD,BioGRID	11071869
SYNJ1	INPP5G	synaptojanin 1	Affinity Capture-Western Far Western	BioGRID	12829691
TAF6	DKFZp781E21155 \| MGC:8964 \| TAF2E \| TAFII70 \| TAFII80 \| TAFII85	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	-	HPRD,BioGRID	12829691
TJP2	MGC26306 \| X104 \| ZO-2 \| ZO2	tight junction protein 2 (zona occludens 2)	-	HPRD,BioGRID	12829691

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
BIOCARTA CBL PATHWAY	13	10	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY	41	35	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	29	24	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME EGFR DOWNREGULATION	25	14	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP	146	86	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP	306	188	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP	265	158	All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS DN	120	73	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN	378	231	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN	234	147	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP	191	128	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN	428	306	All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN	165	104	All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP	268	157	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP	180	114	All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP	126	92	All SZGR 2.0 genes in this pathway
HUANG DASATINIB RESISTANCE UP	81	53	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 LCP WITH H3K4ME3	162	80	All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K4ME3	128	68	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP	149	96	All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP	289	184	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	639	645	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	639	645	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-129-5p	977	983	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	977	983	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-142-5p	362	368	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-153	509	515	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-182	79	85	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-218	144	150	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-22	681	687	1A	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-26	2	8	m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	2	8	m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-33	997	1003	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	997	1003	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-410	579	585	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-448	962	968	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-448	962	968	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-450	977	983	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-542-3p	394	400	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-96	78	85	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: SH3KBP1