Gene Page: HABP2
Summary ?
GeneID | 3026 |
Symbol | HABP2 |
Synonyms | FSAP|HABP|HGFAL|NMTC5|PHBP |
Description | hyaluronan binding protein 2 |
Reference | MIM:603924|HGNC:HGNC:4798|Ensembl:ENSG00000148702|HPRD:04890|Vega:OTTHUMG00000019073 |
Gene type | protein-coding |
Map location | 10q25.3 |
Pascal p-value | 0.006 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
HBD | 0.99 | 0.99 |
SCRG1 | 0.71 | 0.49 |
LGALS3 | 0.69 | 0.51 |
FTL | 0.68 | 0.64 |
RTP4 | 0.67 | 0.50 |
MT3 | 0.66 | 0.52 |
CGRRF1 | 0.66 | 0.43 |
C1orf61 | 0.66 | 0.55 |
PXMP3 | 0.66 | 0.48 |
PSMB8 | 0.65 | 0.57 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
HNRNPUL2 | -0.57 | -0.59 |
MYO18A | -0.54 | -0.54 |
TRAF3IP1 | -0.54 | -0.61 |
GOLGA2 | -0.54 | -0.47 |
GRIPAP1 | -0.54 | -0.52 |
MPHOSPH8 | -0.53 | -0.61 |
NOM1 | -0.53 | -0.59 |
AEBP2 | -0.53 | -0.54 |
ANKRD11 | -0.52 | -0.55 |
SURF6 | -0.52 | -0.52 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0004252 | serine-type endopeptidase activity | IEA | glutamate (GO term level: 7) | - |
GO:0005539 | glycosaminoglycan binding | TAS | 8827452 | |
GO:0008233 | peptidase activity | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0007155 | cell adhesion | TAS | 8827452 | |
GO:0006508 | proteolysis | IEA | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005576 | extracellular region | NAS | 14718574 | |
GO:0005615 | extracellular space | TAS | 8827452 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
OSAWA TNF TARGETS | 10 | 6 | All SZGR 2.0 genes in this pathway |
MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
SU LIVER | 55 | 32 | All SZGR 2.0 genes in this pathway |
KONDO PROSTATE CANCER WITH H3K27ME3 | 196 | 93 | All SZGR 2.0 genes in this pathway |
BOCHKIS FOXA2 TARGETS | 425 | 261 | All SZGR 2.0 genes in this pathway |
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN | 170 | 105 | All SZGR 2.0 genes in this pathway |
COULOUARN TEMPORAL TGFB1 SIGNATURE DN | 138 | 99 | All SZGR 2.0 genes in this pathway |
HOSHIDA LIVER CANCER SURVIVAL DN | 113 | 76 | All SZGR 2.0 genes in this pathway |
CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
SERVITJA LIVER HNF1A TARGETS DN | 157 | 105 | All SZGR 2.0 genes in this pathway |
NABA ECM REGULATORS | 238 | 125 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-143 | 1135 | 1142 | 1A,m8 | hsa-miR-143brain | UGAGAUGAAGCACUGUAGCUCA |
miR-186 | 1185 | 1191 | 1A | hsa-miR-186 | CAAAGAAUUCUCCUUUUGGGCUU |
miR-224 | 1082 | 1088 | m8 | hsa-miR-224 | CAAGUCACUAGUGGUUCCGUUUA |
miR-375 | 929 | 935 | 1A | hsa-miR-375 | UUUGUUCGUUCGGCUCGCGUGA |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.