Gene Page: HAGH

Summary ?
GeneID3029
SymbolHAGH
SynonymsGLO2|GLX2|GLXII|HAGH1
Descriptionhydroxyacylglutathione hydrolase
ReferenceMIM:138760|HGNC:HGNC:4805|HPRD:00731|
Gene typeprotein-coding
Map location16p13.3
Pascal p-value0.009
Sherlock p-value0.371
Fetal beta-0.985
DMG1 (# studies)
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg06782493161876874HAGH;FAHD11.97E-5-0.240.016DMG:Wockner_2014
cg09038527161860756HAGH2.942E-40.2790.039DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs13339350161825774HAGHENSG00000063854.81.237E-6047264gtex_brain_putamen_basal
rs9929680161826023HAGHENSG00000063854.81.158E-6047015gtex_brain_putamen_basal
rs13332165161827522HAGHENSG00000063854.88.034E-7045516gtex_brain_putamen_basal
rs2272977161838037HAGHENSG00000063854.86.258E-8035001gtex_brain_putamen_basal
rs28568973161838337HAGHENSG00000063854.86.1E-8034701gtex_brain_putamen_basal
rs33988059161840362HAGHENSG00000063854.88.667E-7032676gtex_brain_putamen_basal
rs3829563161845190HAGHENSG00000063854.81.029E-6027848gtex_brain_putamen_basal
rs45449099161845630HAGHENSG00000063854.81.034E-6027408gtex_brain_putamen_basal
rs344352161846476HAGHENSG00000063854.85.604E-7026562gtex_brain_putamen_basal
rs344354161846754HAGHENSG00000063854.81.883E-7026284gtex_brain_putamen_basal
rs9933403161850194HAGHENSG00000063854.81.474E-7022844gtex_brain_putamen_basal
rs2575340161853701HAGHENSG00000063854.83.734E-8019337gtex_brain_putamen_basal
rs2575339161853859HAGHENSG00000063854.81.035E-7019179gtex_brain_putamen_basal
rs2745192161853870HAGHENSG00000063854.81.056E-7019168gtex_brain_putamen_basal
rs2745193161853959HAGHENSG00000063854.81.045E-6019079gtex_brain_putamen_basal
rs2745194161854038HAGHENSG00000063854.86.465E-8019000gtex_brain_putamen_basal
rs113041534161856368HAGHENSG00000063854.87.185E-8016670gtex_brain_putamen_basal
rs8047464161856440HAGHENSG00000063854.85.797E-7016598gtex_brain_putamen_basal
rs200327289161864926HAGHENSG00000063854.86.386E-808112gtex_brain_putamen_basal
rs2268669161871727HAGHENSG00000063854.83.7E-801311gtex_brain_putamen_basal
rs238678161872722HAGHENSG00000063854.81.522E-70316gtex_brain_putamen_basal
rs2437728161874232HAGHENSG00000063854.81.571E-60-1194gtex_brain_putamen_basal
rs7187048161876261HAGHENSG00000063854.81.277E-80-3223gtex_brain_putamen_basal
rs116869551161876619HAGHENSG00000063854.83.887E-80-3581gtex_brain_putamen_basal
rs7188401161876949HAGHENSG00000063854.81.182E-70-3911gtex_brain_putamen_basal
rs3743852161877698HAGHENSG00000063854.84.597E-80-4660gtex_brain_putamen_basal
rs13166161877913HAGHENSG00000063854.84.597E-80-4875gtex_brain_putamen_basal
rs7185299161879423HAGHENSG00000063854.84.597E-80-6385gtex_brain_putamen_basal
rs111646775161880431HAGHENSG00000063854.84.597E-80-7393gtex_brain_putamen_basal
rs8044343161881145HAGHENSG00000063854.81.735E-70-8107gtex_brain_putamen_basal
rs9944346161881197HAGHENSG00000063854.84.597E-80-8159gtex_brain_putamen_basal
rs238677161883279HAGHENSG00000063854.81.33E-60-10241gtex_brain_putamen_basal
rs171162161884501HAGHENSG00000063854.81.521E-70-11463gtex_brain_putamen_basal
rs186938161885537HAGHENSG00000063854.81.923E-60-12499gtex_brain_putamen_basal
rs13332303161885632HAGHENSG00000063854.84.597E-80-12594gtex_brain_putamen_basal
rs12325217161887108HAGHENSG00000063854.84.933E-80-14070gtex_brain_putamen_basal
rs143636881161887201HAGHENSG00000063854.84.152E-80-14163gtex_brain_putamen_basal
rs199575059161891184HAGHENSG00000063854.81.127E-70-18146gtex_brain_putamen_basal
rs112539690161891309HAGHENSG00000063854.85.902E-80-18271gtex_brain_putamen_basal
rs116215052161893312HAGHENSG00000063854.85.902E-80-20274gtex_brain_putamen_basal
rs56934115161893596HAGHENSG00000063854.85.902E-80-20558gtex_brain_putamen_basal
rs3848350161893882HAGHENSG00000063854.85.902E-80-20844gtex_brain_putamen_basal
rs9806826161894912HAGHENSG00000063854.83.463E-70-21874gtex_brain_putamen_basal
rs3848352161895297HAGHENSG00000063854.81.348E-60-22259gtex_brain_putamen_basal
rs9931865161897201HAGHENSG00000063854.86.181E-80-24163gtex_brain_putamen_basal
rs1742414161898097HAGHENSG00000063854.81.481E-60-25059gtex_brain_putamen_basal
rs111688244161898638HAGHENSG00000063854.85.902E-80-25600gtex_brain_putamen_basal
rs142077410161899106HAGHENSG00000063854.85.902E-80-26068gtex_brain_putamen_basal
rs61589779161899115HAGHENSG00000063854.85.902E-80-26077gtex_brain_putamen_basal
rs1742417161900705HAGHENSG00000063854.83.036E-70-27667gtex_brain_putamen_basal
rs9921618161901721HAGHENSG00000063854.85.425E-80-28683gtex_brain_putamen_basal
rs2492883161902105HAGHENSG00000063854.82.459E-70-29067gtex_brain_putamen_basal
rs7187251161902901HAGHENSG00000063854.85.872E-80-29863gtex_brain_putamen_basal
rs10500322161904239HAGHENSG00000063854.81.484E-60-31201gtex_brain_putamen_basal
rs5006376161905201HAGHENSG00000063854.81.053E-60-32163gtex_brain_putamen_basal
rs57407778161906017HAGHENSG00000063854.84.901E-80-32979gtex_brain_putamen_basal
rs9746488161906233HAGHENSG00000063854.83.57E-70-33195gtex_brain_putamen_basal
rs10500323161907558HAGHENSG00000063854.85.902E-80-34520gtex_brain_putamen_basal
rs2437745161908431HAGHENSG00000063854.83.463E-70-35393gtex_brain_putamen_basal
rs2437744161908451HAGHENSG00000063854.83.463E-70-35413gtex_brain_putamen_basal
rs11863172161909083HAGHENSG00000063854.83.036E-60-36045gtex_brain_putamen_basal
rs413308161909484HAGHENSG00000063854.83.463E-70-36446gtex_brain_putamen_basal
rs388928161909657HAGHENSG00000063854.83.463E-70-36619gtex_brain_putamen_basal
rs7191695161909971HAGHENSG00000063854.85.902E-80-36933gtex_brain_putamen_basal
rs7202283161910015HAGHENSG00000063854.85.902E-80-36977gtex_brain_putamen_basal
rs1742438161911134HAGHENSG00000063854.81.281E-70-38096gtex_brain_putamen_basal
rs1657125161912021HAGHENSG00000063854.84.234E-70-38983gtex_brain_putamen_basal
rs1657126161912205HAGHENSG00000063854.81.28E-70-39167gtex_brain_putamen_basal
rs28460464161912616HAGHENSG00000063854.85.902E-80-39578gtex_brain_putamen_basal
rs28610155161912695HAGHENSG00000063854.85.902E-80-39657gtex_brain_putamen_basal
rs2983907161913336HAGHENSG00000063854.83.463E-70-40298gtex_brain_putamen_basal
rs392913161913520HAGHENSG00000063854.81.324E-60-40482gtex_brain_putamen_basal
rs199576536161913752HAGHENSG00000063854.81.462E-70-40714gtex_brain_putamen_basal
rs147632179161913753HAGHENSG00000063854.81.5E-70-40715gtex_brain_putamen_basal
rs7188124161915360HAGHENSG00000063854.85.902E-80-42322gtex_brain_putamen_basal
rs2917521161915585HAGHENSG00000063854.86.552E-80-42547gtex_brain_putamen_basal
rs58422887161915886HAGHENSG00000063854.85.902E-80-42848gtex_brain_putamen_basal
rs9928722161916336HAGHENSG00000063854.85.902E-80-43298gtex_brain_putamen_basal
rs78268797161918094HAGHENSG00000063854.86.109E-80-45056gtex_brain_putamen_basal
rs9934984161919102HAGHENSG00000063854.86.105E-80-46064gtex_brain_putamen_basal
rs2437747161919665HAGHENSG00000063854.81.521E-60-46627gtex_brain_putamen_basal
rs12719796161921197HAGHENSG00000063854.83.327E-70-48159gtex_brain_putamen_basal
rs71384658161922216HAGHENSG00000063854.81.006E-60-49178gtex_brain_putamen_basal
rs201703905161966608HAGHENSG00000063854.88.482E-70-93570gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC104389.50.920.73
HBG20.910.74
HBA10.870.70
HBA20.850.63
HBZ0.820.66
HBG10.780.70
ERAF0.760.68
GPC40.740.37
ALAS20.730.67
HK20.730.48
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HLA-F-0.41-0.66
C5orf53-0.41-0.60
FBXO2-0.40-0.62
LHPP-0.40-0.54
TNFSF12-0.40-0.56
APOL1-0.40-0.68
AIFM3-0.40-0.65
HEPN1-0.39-0.64
SLC16A11-0.39-0.56
ALDOC-0.39-0.62

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PYRUVATE METABOLISM 4026All SZGR 2.0 genes in this pathway
PID P73PATHWAY 7959All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 16P13 AMPLICON 12049All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE UP 7851All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203130All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293160All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN 3321All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
MELLMAN TUT1 TARGETS DN 4729All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN 17997All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway