Gene Page: SERPIND1

Summary ?
GeneID3053
SymbolSERPIND1
SynonymsD22S673|HC2|HCF2|HCII|HLS2|LS2|THPH10
Descriptionserpin peptidase inhibitor, clade D (heparin cofactor), member 1
ReferenceMIM:142360|HGNC:HGNC:4838|Ensembl:ENSG00000099937|HPRD:00795|Vega:OTTHUMG00000150755
Gene typeprotein-coding
Map location22q11.21
Pascal p-value0.252
Fetal beta0.567
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17131472chr191962966SERPIND130530.09trans
rs6718379chr218632808SERPIND130530.13trans
rs17015803chr2120191430SERPIND130530.03trans
rs2922180chr3125280472SERPIND130530.03trans
rs2971271chr3125450402SERPIND130530.14trans
rs2976809chr3125451738SERPIND130531.705E-4trans
rs64491690SERPIND130530.18trans
rs313946chr4113975904SERPIND130530.07trans
rs657141chr4113981041SERPIND130530.16trans
rs17381134chr4157179855SERPIND130530.08trans
rs2294262chr616108966SERPIND130530.19trans
rs4236095chr647368686SERPIND130530.16trans
rs6455226chr667930295SERPIND130530.01trans
rs2718035chr736132888SERPIND130530.03trans
rs3110902chr765375101SERPIND130530.13trans
rs7841407chr89243427SERPIND130530.09trans
rs680372chr836999626SERPIND130530.18trans
rs4514358chr1043861923SERPIND130530.02trans
rs11016704chr10128989145SERPIND130530.07trans
rs17134872chr1176139845SERPIND130530.16trans
rs11236774chr1176234952SERPIND130530.16trans
rs9529974chr1372821935SERPIND130530trans
rs7164640chr1580661303SERPIND130530.12trans
rs11873703chr1861448702SERPIND130530.03trans
snp_a-19133450SERPIND130530.12trans
rs293737chr2031925477SERPIND130530.1trans
rs6095741chr2048666589SERPIND130530trans
rs17255719chrX12144766SERPIND130530.09trans
rs5991662chrX43335796SERPIND130530.06trans
rs6529399chrX128763582SERPIND130530.04trans
rs3761581chrX128789720SERPIND130530trans
rs242163chrX132311662SERPIND130530.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BRIP10.970.76
FANCI0.970.70
MELK0.970.83
KIF230.970.75
SMC40.960.79
BUB1B0.960.79
ERCC6L0.960.73
BRCA20.960.80
BUB10.960.79
MCM100.960.79
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FBXO2-0.45-0.70
SLC9A3R2-0.45-0.54
LHPP-0.45-0.66
HLA-F-0.45-0.73
PTH1R-0.44-0.69
C5orf53-0.44-0.68
ASPHD1-0.44-0.62
TNFSF12-0.44-0.66
ALDOC-0.43-0.67
AIFM3-0.43-0.68

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004867serine-type endopeptidase inhibitor activityIEA-
GO:0008201heparin bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007596blood coagulationIEA-
GO:0006935chemotaxisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG COMPLEMENT AND COAGULATION CASCADES 6949All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
HUMMERICH BENIGN SKIN TUMOR UP 188All SZGR 2.0 genes in this pathway
MUELLER METHYLATED IN GLIOBLASTOMA 4022All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS DN 10884All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP 5030All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY UP 4529All SZGR 2.0 genes in this pathway
SU LIVER 5532All SZGR 2.0 genes in this pathway
WILSON PROTEASES AT TUMOR BONE INTERFACE UP 2114All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP 7149All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE DN 13899All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
CERIBELLI PROMOTERS INACTIVE AND BOUND BY NFY 4420All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway