Gene Page: SERPIND1

Summary
GeneID  3053
Symbol  SERPIND1
Synonyms  D22S673|HC2|HCF2|HCII|HLS2|LS2
Description  serpin peptidase inhibitor, clade D (heparin cofactor), member 1
See related  HGNC:4838|MIM:142360|Ensembl:ENSG00000099937|HPRD:00795|
Locus tag  -
Gene type  protein-coding
Map location  22q11.2|22q11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BRIP10.970.76
FANCI0.970.70
MELK0.970.83
KIF230.970.75
SMC40.960.79
BUB1B0.960.79
ERCC6L0.960.73
BRCA20.960.80
BUB10.960.79
MCM100.960.79
Top 10 negatively co-expressed genes
FBXO2-0.45-0.70
SLC9A3R2-0.45-0.54
LHPP-0.45-0.66
HLA-F-0.45-0.73
PTH1R-0.44-0.69
C5orf53-0.44-0.68
ASPHD1-0.44-0.62
TNFSF12-0.44-0.66
ALDOC-0.43-0.67
AIFM3-0.43-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004867serine-type endopeptidase inhibitor activityIEA-
GO:0008201heparin bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007596blood coagulationIEA-
GO:0006935chemotaxisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
F2PTcoagulation factor II (thrombin)Co-crystal StructureBioGRID12169660 
-HPRD2760054 
SERPIND1D22S673 | HC2 | HCF2 | HCII | HLS2 | LS2serpin peptidase inhibitor, clade D (heparin cofactor), member 1-HPRD12169660 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 6949All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
HUMMERICH_BENIGN_SKIN_TUMOR_UP 188All SZGR genes in this pathway
MUELLER_METHYLATED_IN_GLIOBLASTOMA 4022All SZGR genes in this pathway
LE_EGR2_TARGETS_DN 10884All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_UP 5030All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS 185114All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
MCDOWELL_ACUTE_LUNG_INJURY_UP 4529All SZGR genes in this pathway
SU_LIVER 5532All SZGR genes in this pathway
WILSON_PROTEASES_AT_TUMOR_BONE_INTERFACE_UP 2114All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
GU_PDEF_TARGETS_UP 7149All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN 13899All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_DN 222141All SZGR genes in this pathway
CERIBELLI_PROMOTERS_INACTIVE_AND_BOUND_BY_NFY 4420All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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