SZGR2

Summary ?

GeneID	3066
Symbol	HDAC2
Synonyms	HD2\|RPD3\|YAF1
Description	histone deacetylase 2
Reference	MIM:605164\|HGNC:HGNC:4853\|Ensembl:ENSG00000196591\|HPRD:05521\|Vega:OTTHUMG00000015411
Gene type	protein-coding
Map location	6q21
Pascal p-value	0.619
Sherlock p-value	0.685
Fetal beta	3.022
DMG	1 (# studies)
Support	Chromatin Remodeling Genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0021

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg15069235	6	114289969	HDAC2	5.819E-4	-0.462	0.049	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AC113209.3	0.82	0.83
GPR156	0.82	0.86
FHOD3	0.77	0.83
PUS7	0.75	0.80
BRD2	0.75	0.81
TOPBP1	0.75	0.81
EXT1	0.75	0.81
SEPT11	0.74	0.78
MSL1	0.74	0.81
ANKLE2	0.74	0.78

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.33	-0.69	-0.75
MT-CO2	-0.68	-0.75
AF347015.31	-0.67	-0.73
FXYD1	-0.66	-0.74
MT-CYB	-0.66	-0.73
AF347015.27	-0.66	-0.74
AF347015.8	-0.66	-0.74
AF347015.2	-0.65	-0.73
S100B	-0.64	-0.73
AF347015.26	-0.64	-0.72

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003700	transcription factor activity	TAS		8917507
GO:0004407	histone deacetylase activity	IEA		-
GO:0004407	histone deacetylase activity	TAS		12711221
GO:0016787	hydrolase activity	IEA		-
GO:0008134	transcription factor binding	TAS		12711221
GO:0019899	enzyme binding	IPI		11062478
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	TAS		8917507
GO:0006350	transcription	IEA		-
GO:0016568	chromatin modification	TAS		12711221
GO:0016575	histone deacetylation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000118	histone deacetylase complex	TAS		12711221
GO:0000792	heterochromatin	IEA		-
GO:0005634	nucleus	IEA		-
GO:0005634	nucleus	TAS		12711221
GO:0005657	replication fork	IEA		-
GO:0005737	cytoplasm	TAS		12711221

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANTXR1	ATR \| FLJ10601 \| FLJ11298 \| FLJ21776 \| TEM8	anthrax toxin receptor 1	-	HPRD	10545197
AOF2	BHC110 \| KDM1 \| KIAA0601 \| LSD1	amine oxidase (flavin containing) domain 2	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	9804427 \|12032298 \|12493763
ARID4A	RBBP1 \| RBP-1 \| RBP1	AT rich interactive domain 4A (RBP1-like)	-	HPRD	10490602
ARID4B	BCAA \| BRCAA1 \| DKFZp313M2420 \| MGC163290 \| RBBP1L1 \| RBP1L1 \| SAP180	AT rich interactive domain 4B (RBP1-like)	Affinity Capture-Western	BioGRID	12724404
ATR	FRP1 \| MEC1 \| SCKL \| SCKL1	ataxia telangiectasia and Rad3 related	Affinity Capture-Western Co-purification	BioGRID	10545197
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD,BioGRID	10220405
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	BRCA1 interacts with HDAC2	BIND	10220405
BUB3	BUB3L \| hBUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	Affinity Capture-Western Co-purification	BioGRID	15388328
CABIN1	CAIN \| KIAA0330 \| PPP3IN	calcineurin binding protein 1	-	HPRD,BioGRID	10933397
CBFA2T3	ETO2 \| MTG16 \| MTGR2 \| ZMYND4	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	Affinity Capture-Western	BioGRID	11533236
CDC20	CDC20A \| MGC102824 \| bA276H19.3 \| p55CDC	cell division cycle 20 homolog (S. cerevisiae)	Affinity Capture-Western Co-purification	BioGRID	15388328
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Affinity Capture-Western Co-purification	BioGRID	15388328
CDK7	CAK1 \| CDKN7 \| MO15 \| STK1 \| p39MO15	cyclin-dependent kinase 7	Affinity Capture-Western	BioGRID	12527756
CDYL	CDYL1 \| DKFZp586C1622 \| MGC131936	chromodomain protein, Y-like	-	HPRD,BioGRID	12947414
CHD3	Mi-2a \| Mi2-ALPHA \| ZFH	chromodomain helicase DNA binding protein 3	-	HPRD,BioGRID	9804427
CHD4	DKFZp686E06161 \| Mi-2b \| Mi2-BETA	chromodomain helicase DNA binding protein 4	Affinity Capture-MS Affinity Capture-Western	BioGRID	9804427 \|10545197 \|12493763
CIR	-	CBF1 interacting corepressor	-	HPRD	9874765
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	-	HPRD,BioGRID	12176973
CTBP1	BARS \| MGC104684	C-terminal binding protein 1	-	HPRD,BioGRID	10766745
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	death-domain associated protein	Far Western	BioGRID	10669754
DMAP1	DKFZp686L09142 \| DNMAP1 \| DNMTAP1 \| EAF2 \| FLJ11543 \| KIAA1425 \| SWC4	DNA methyltransferase 1 associated protein 1	-	HPRD	10888872
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	DNMT1 interacts with HDAC2.	BIND	10888872
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	-	HPRD,BioGRID	10888872
DNMT3B	ICF \| M.HsaIIIB	DNA (cytosine-5-)-methyltransferase 3 beta	DNMT3B interacts with HDAC2.	BIND	15120635
EED	HEED \| WAIT1	embryonic ectoderm development	-	HPRD,BioGRID	10581039
EID2	CRI2 \| EID-2 \| MGC20452	EP300 interacting inhibitor of differentiation 2	-	HPRD	12586827
EZH2	ENX-1 \| EZH1 \| KMT6 \| MGC9169	enhancer of zeste homolog 2 (Drosophila)	Affinity Capture-Western	BioGRID	10581039
FKBP3	FKBP-25 \| PPIase	FK506 binding protein 3, 25kDa	-	HPRD,BioGRID	11532945
GATAD2B	FLJ37346 \| KIAA1150 \| MGC138257 \| MGC138285 \| P66beta \| RP11-216N14.6	GATA zinc finger domain containing 2B	Affinity Capture-Western	BioGRID	11756549
GTF2I	BAP-135 \| BAP135 \| BTKAP1 \| DIWS \| FLJ38776 \| FLJ56355 \| IB291 \| SPIN \| TFII-I \| WBS \| WBSCR6	general transcription factor II, i	Affinity Capture-MS Affinity Capture-Western	BioGRID	12393887 \|12493763
HCFC1	CFF \| HCF-1 \| HCF1 \| HFC1 \| MGC70925 \| VCAF	host cell factor C1 (VP16-accessory protein)	Affinity Capture-MS Affinity Capture-Western	BioGRID	12670868
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD,BioGRID	9520398
HDAC10	DKFZp761B039 \| MGC149722	histone deacetylase 10	-	HPRD,BioGRID	11739383
HDAC2	RPD3 \| YAF1	histone deacetylase 2	Affinity Capture-MS	BioGRID	12493763
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Reconstituted Complex	BioGRID	11641274
HIF1AN	DKFZp762F1811 \| FIH1 \| FLJ20615 \| FLJ22027	hypoxia-inducible factor 1, alpha subunit inhibitor	-	HPRD,BioGRID	11641274
HMG20B	BRAF25 \| BRAF35 \| FLJ26127 \| HMGX2 \| PP7706 \| SMARCE1r \| SOXL \| pp8857	high-mobility group 20B	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	12032298 \|12493763
HOPX	Cameo \| HOP \| LAGY \| MGC20820 \| NECC1 \| OB1 \| SMAP31 \| Toto	HOP homeobox	-	HPRD,BioGRID	12975471
HR	ALUNC \| AU \| HSA277165	hairless homolog (mouse)	Affinity Capture-Western	BioGRID	11641275
HSPA4	APG-2 \| HS24/P52 \| MGC131852 \| RY \| hsp70 \| hsp70RY	heat shock 70kDa protein 4	Affinity Capture-Western	BioGRID	11777905
IFRD1	PC4 \| TIS7	interferon-related developmental regulator 1	-	HPRD	12198164
IKZF1	Hs.54452 \| IK1 \| IKAROS \| LYF1 \| PRO0758 \| ZNFN1A1 \| hIk-1	IKAROS family zinc finger 1 (Ikaros)	Affinity Capture-Western	BioGRID	12015313
IKZF2	HELIOS \| MGC34330 \| ZNF1A2 \| ZNFN1A2	IKAROS family zinc finger 2 (Helios)	Affinity Capture-Western	BioGRID	12015313
IKZF3	AIO \| AIOLOS \| ZNFN1A3	IKAROS family zinc finger 3 (Aiolos)	Affinity Capture-Western	BioGRID	12015313
IKZF4	EOS \| KIAA1782 \| ZNFN1A4	IKAROS family zinc finger 4 (Eos)	-	HPRD,BioGRID	12015313
ING1	p24ING1c \| p33 \| p33ING1 \| p33ING1b \| p47 \| p47ING1a	inhibitor of growth family, member 1	Affinity Capture-MS	BioGRID	11784859
KIAA0182	GSE1	KIAA0182	Affinity Capture-MS	BioGRID	12493763
MAD1L1	HsMAD1 \| MAD1 \| PIG9 \| TP53I9 \| TXBP181	MAD1 mitotic arrest deficient-like 1 (yeast)	Affinity Capture-Western Co-purification	BioGRID	15388328
MBD2	DKFZp586O0821 \| DMTase \| NY-CO-41	methyl-CpG binding domain protein 2	-	HPRD,BioGRID	10471499
MBD3	-	methyl-CpG binding domain protein 3	Affinity Capture-Western	BioGRID	12354758
MBD3L1	MBD3L \| MGC138263 \| MGC138269	methyl-CpG binding domain protein 3-like 1	Affinity Capture-Western	BioGRID	15456747
MTA1	-	metastasis associated 1	-	HPRD,BioGRID	11146623
MTA2	DKFZp686F2281 \| MTA1L1 \| PID	metastasis associated 1 family, member 2	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	10444591 \|12493763 \|12920132
MXD1	MAD \| MAD1 \| MGC104659	MAX dimerization protein 1	-	HPRD,BioGRID	9150134
NCOR2	CTG26 \| SMRT \| SMRTE \| SMRTE-tau \| TNRC14 \| TRAC-1 \| TRAC1	nuclear receptor co-repressor 2	Co-purification	BioGRID	11013263
PA2G4	EBP1 \| HG4-1 \| p38-2G4	proliferation-associated 2G4, 38kDa	-	HPRD,BioGRID	12682367
PA2G4	EBP1 \| HG4-1 \| p38-2G4	proliferation-associated 2G4, 38kDa	HDAC2 interacts with Ebp1	BIND	12682367
PHF21A	BHC80 \| BM-006 \| KIAA1696	PHD finger protein 21A	-	HPRD,BioGRID	15325272
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD,BioGRID	11259576 \|11430826
PPARD	FAAR \| MGC3931 \| NR1C2 \| NUC1 \| NUCI \| NUCII \| PPAR-beta \| PPARB	peroxisome proliferator-activated receptor delta	-	HPRD,BioGRID	11867749
PPP1R8	ARD-1 \| ARD1 \| NIPP-1 \| NIPP1 \| PRO2047	protein phosphatase 1, regulatory (inhibitor) subunit 8	-	HPRD,BioGRID	12788942
PTMA	MGC104802 \| TMSA	prothymosin, alpha	-	HPRD,BioGRID	12634383
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Affinity Capture-Western	BioGRID	10490602
RBBP4	NURF55 \| RBAP48	retinoblastoma binding protein 4	-	HPRD	11302704 \|12091390 \|12943729
RBBP4	NURF55 \| RBAP48	retinoblastoma binding protein 4	Affinity Capture-MS Affinity Capture-Western	BioGRID	9804427 \|12091390 \|12493763 \|12943729
RBBP7	MGC138867 \| MGC138868 \| RbAp46	retinoblastoma binding protein 7	Affinity Capture-MS	BioGRID	12493763
RBL1	CP107 \| MGC40006 \| PRB1 \| p107	retinoblastoma-like 1 (p107)	Affinity Capture-Western	BioGRID	10490602
RCOR1	COREST \| KIAA0071 \| RCOR	REST corepressor 1	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	11171972 \|12032298
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	12138131 \|12419806
RUNX1T1	AML1T1 \| CBFA2T1 \| CDR \| ETO \| MGC2796 \| MTG8 \| MTG8b \| ZMYND2	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	Affinity Capture-Western	BioGRID	11533236
RUNX3	AML2 \| CBFA3 \| FLJ34510 \| MGC16070 \| PEBP2aC	runt-related transcription factor 3	-	HPRD	15138260
SALL1	HSAL1 \| TBS \| ZNF794	sal-like 1 (Drosophila)	-	HPRD	11836251
SAP130	FLJ12761	Sin3A-associated protein, 130kDa	Affinity Capture-Western	BioGRID	12724404
SAP30	-	Sin3A-associated protein, 30kDa	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	9651585 \|10444591 \|11784859
SATB1	-	SATB homeobox 1	Co-fractionation	BioGRID	12374985
SETDB1	ESET \| KG1T \| KIAA0067 \| KMT1E	SET domain, bifurcated 1	Affinity Capture-Western	BioGRID	12398767
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	-	HPRD	11013263
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	The transcriptional repressor mSin3A interacts with histone deacetylase 2.	BIND	9150134
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	Affinity Capture-MS Affinity Capture-Western	BioGRID	9150134 \|9804427 \|12091390 \|12398767 \|12493763 \|12724404 \|12943729
SMARCA2	BAF190 \| BRM \| FLJ36757 \| MGC74511 \| SNF2 \| SNF2L2 \| SNF2LA \| SWI2 \| Sth1p \| hBRM \| hSNF2a	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Co-purification	BioGRID	11238380
SMARCA4	BAF190 \| BRG1 \| FLJ39786 \| SNF2 \| SNF2-BETA \| SNF2L4 \| SNF2LB \| SWI2 \| hSNF2b	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Co-purification	BioGRID	11238380
SMARCA5	ISWI \| SNF2H \| WCRF135 \| hISWI \| hSNF2H	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	SMARCA5 (SNF2h) interacts with HDAC2.	BIND	15775975
SMARCA5	ISWI \| SNF2H \| WCRF135 \| hISWI \| hSNF2H	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	Co-purification	BioGRID	12198550
SMARCB1	BAF47 \| INI1 \| RDT \| SNF5 \| SNF5L1 \| Sfh1p \| Snr1 \| hSNFS	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Co-purification	BioGRID	11238380
SMC3	BAM \| BMH \| CDLS3 \| CSPG6 \| HCAP \| SMC3L1	structural maintenance of chromosomes 3	Co-purification	BioGRID	12198550
SNW1	Bx42 \| MGC119379 \| NCOA-62 \| PRPF45 \| Prp45 \| SKIIP \| SKIP	SNW domain containing 1	-	HPRD,BioGRID	10644367
SP1	-	Sp1 transcription factor	-	HPRD,BioGRID	12151407
SP3	DKFZp686O1631 \| SPR-2	Sp3 transcription factor	-	HPRD,BioGRID	12151407
SPEN	KIAA0929 \| MINT \| RP1-134O19.1 \| SHARP	spen homolog, transcriptional regulator (Drosophila)	-	HPRD	11331609
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	Stat3 interacts with HDAC2.	BIND	15653507
SUDS3	FLJ00052 \| MGC104711 \| SAP45 \| SDS3	suppressor of defective silencing 3 homolog (S. cerevisiae)	Affinity Capture-Western	BioGRID	12724404
SUV39H1	KMT1A \| MG44 \| SUV39H	suppressor of variegation 3-9 homolog 1 (Drosophila)	-	HPRD,BioGRID	11788710
TAL1	SCL \| TCL5 \| bHLHa17 \| tal-1	T-cell acute lymphocytic leukemia 1	Affinity Capture-MS	BioGRID	16407974
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	-	HPRD	10508171
TNFSF10	APO2L \| Apo-2L \| CD253 \| TL2 \| TRAIL	tumor necrosis factor (ligand) superfamily, member 10	HDAC2 interacts with the TNFSF10 promoter.	BIND	15619633
TOP2A	TOP2 \| TP2A	topoisomerase (DNA) II alpha 170kDa	-	HPRD,BioGRID	11062478
TOP2B	TOPIIB \| top2beta	topoisomerase (DNA) II beta 180kDa	Affinity Capture-Western Reconstituted Complex	BioGRID	11062478
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	Reconstituted Complex	BioGRID	11641274
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	YY1 interacts with RPD3. This interaction was modelled on a demonstrated interaction between human YY1 and mouse RPD3.	BIND	8917507
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	-	HPRD,BioGRID	11486036
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	Reconstituted Complex	BioGRID	15467736
ZMYM2	FIM \| MYM \| RAMP \| SCLL \| ZNF198	zinc finger, MYM-type 2	Affinity Capture-MS	BioGRID	12493763
ZMYM3	DXS6673E \| KIAA0385 \| MYM \| XFIM \| ZNF198L2 \| ZNF261	zinc finger, MYM-type 3	Affinity Capture-MS	BioGRID	12493763

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG NOTCH SIGNALING PATHWAY	47	35	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
BIOCARTA CARM ER PATHWAY	35	27	All SZGR 2.0 genes in this pathway
BIOCARTA ETS PATHWAY	18	12	All SZGR 2.0 genes in this pathway
BIOCARTA MEF2D PATHWAY	23	16	All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY	82	63	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY	68	48	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY	48	35	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	46	28	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1	70	46	All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	81	61	All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	132	101	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH	103	64	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN	232	139	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS DN	133	77	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP	191	128	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL	330	215	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM	159	93	All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 LASER DN	50	38	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION	147	80	All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED	100	68	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING DN	90	57	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN	185	111	All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 UP	51	30	All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP	108	75	All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN	85	56	All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE DN	52	37	All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL	89	60	All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP	65	44	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP	174	96	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN	245	150	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN	238	145	All SZGR 2.0 genes in this pathway
LEE RECENT THYMIC EMIGRANT	227	128	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP	178	108	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP	62	42	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP	207	143	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT UP	166	105	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway

Gene Page: HDAC2