Gene Page: ACACA

Summary
GeneID  31
Symbol  ACACA
Synonyms  ACAC|ACC|ACC1|ACCA
Description  acetyl-Coenzyme A carboxylase alpha
See related  HGNC:84|MIM:200350|Ensembl:ENSG00000132142|HPRD:01938|
Locus tag  -
Gene type  protein-coding
Map location  17q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0962 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DARS0.790.74
C11orf540.780.68
C6orf720.780.77
SCP20.760.72
DPY19L40.750.70
PNRC20.750.68
SEPT20.730.68
RHOA0.730.62
ZNF6800.720.67
PTCD30.720.65
Top 10 negatively co-expressed genes
AF347015.21-0.37-0.15
IL32-0.36-0.21
C10orf10-0.33-0.24
AL022328.1-0.33-0.23
IFI27-0.32-0.19
MT-CO2-0.32-0.18
ISG20-0.31-0.19
TMEM88-0.31-0.32
GZMM-0.30-0.26
CSAG1-0.30-0.20
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003989acetyl-CoA carboxylase activityTAS7905825 
GO:0004075biotin carboxylase activityIEA-
GO:0005515protein bindingIPI16326698 
GO:0005524ATP bindingIEA-
GO:0016874ligase activityIEA-
GO:0009374biotin bindingIEA-
GO:0030145manganese ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008152metabolic processIEA-
GO:0006633fatty acid biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID12360400 
BRCA1 interacts with acetyl-CoA carboxylase.BIND12360400 
CHGBSCG1chromogranin B (secretogranin 1)Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PYRUVATE_METABOLISM 4026All SZGR genes in this pathway
KEGG_PROPANOATE_METABOLISM 3322All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
BIOCARTA_CHREBP2_PATHWAY 4235All SZGR genes in this pathway
BIOCARTA_LEPTIN_PATHWAY 1111All SZGR genes in this pathway
REACTOME_TRIGLYCERIDE_BIOSYNTHESIS 3826All SZGR genes in this pathway
REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS 1815All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_UP 8140All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN 13976All SZGR genes in this pathway
ODONNELL_TARGETS_OF_MYC_AND_TFRC_DN 4525All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP 214144All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_DN 13797All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP 197135All SZGR genes in this pathway
MIDORIKAWA_AMPLIFIED_IN_LIVER_CANCER 5538All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q11_Q21_AMPLICON 13378All SZGR genes in this pathway
SMITH_LIVER_CANCER 4527All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP 10467All SZGR genes in this pathway
STAMBOLSKY_RESPONSE_TO_VITAMIN_D3_UP 8448All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
HORTON_SREBF_TARGETS 2520All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1150615121Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-200bc/429211217m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-378*465471m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-505229423001Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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