Gene Page: HP

Summary ?
GeneID3240
SymbolHP
SynonymsBP|HP2ALPHA2|HPA1S
Descriptionhaptoglobin
ReferenceMIM:140100|HGNC:HGNC:5141|Ensembl:ENSG00000257017|HPRD:00772|Vega:OTTHUMG00000173009
Gene typeprotein-coding
Map location16q22.2
Pascal p-value0.3
Sherlock p-value0.893
Fetal beta-0.927
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Frontal Cortex BA9
Nucleus accumbens basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg095847111672096944HP1.153E-4-6.894DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4788579chr1671951844HP32400cis
rs12708919chr1671986994HP32400.01cis
rs9925462chr1672000194HP32408.622E-9cis
rs1667060chr22945454HP32400.13trans
rs5009574chr24963368HP32400.19trans
rs17026940chr286342788HP32400.16trans
rs7340510chr2134267368HP32400.01trans
rs6730679chr2134282345HP32400.01trans
rs11929728chr46145405HP32400.16trans
rs1511040chr413913575HP32400.03trans
rs16848149chr473443003HP32400.01trans
rs1426729chr4100671473HP32400.19trans
rs680474chr515515788HP32400.08trans
rs9381511chr612931447HP32400.02trans
rs12663450chr638135729HP32400.05trans
rs1381599chr746340766HP32400.03trans
rs6970701chr793087543HP32400.17trans
rs12111850chr793126467HP32400.17trans
rs6949752chr793138081HP32400.17trans
rs17165529chr793144582HP32400.17trans
rs1336572chr9254326HP32400.03trans
rs13289308chr98971665HP32400.11trans
rs17038857chr12107300920HP32404.763E-4trans
rs1457420chr1466958675HP32400.17trans
rs17137819chr165372534HP32400.13trans
rs16958302chr1657647432HP32400.01trans
rs4788579chr1671951844HP32400.18trans
rs9925462chr1672000194HP32402.078E-6trans
rs17001072chr1911099774HP32400.14trans
rs6100270chr2057487204HP32400.04trans
rs71852151672034864HPENSG00000257017.44.687E-60-55196gtex_brain_ba24
rs116480031672052348HPENSG00000257017.49.821E-80-37712gtex_brain_ba24
rs129248861672075593HPENSG00000257017.44.873E-80-14467gtex_brain_ba24
rs352839111672078989HPENSG00000257017.44.654E-80-11071gtex_brain_ba24
rs71974531672079127HPENSG00000257017.42.412E-60-10933gtex_brain_ba24
rs71978691672079352HPENSG00000257017.42.412E-60-10708gtex_brain_ba24
rs54721672088467HPENSG00000257017.44.472E-70-1593gtex_brain_ba24
rs80620411672088964HPENSG00000257017.42.366E-60-1096gtex_brain_ba24
rs37946951672097827HPENSG00000257017.41.081E-707767gtex_brain_ba24
rs340420701672101525HPENSG00000257017.41.179E-7011465gtex_brain_ba24
rs20009991672108093HPENSG00000257017.41.049E-7018033gtex_brain_ba24
rs28549561672115238HPENSG00000257017.41.135E-6025178gtex_brain_ba24
rs99410871672118324HPENSG00000257017.42.562E-6028264gtex_brain_ba24
rs3977689261672121552HPENSG00000257017.42.631E-6031492gtex_brain_ba24
rs124455861672126276HPENSG00000257017.44.297E-6036216gtex_brain_ba24
rs10503621672130815HPENSG00000257017.41.541E-6040755gtex_brain_ba24
rs347497711672131740HPENSG00000257017.41.614E-6041680gtex_brain_ba24
rs64995591672132064HPENSG00000257017.41.541E-6042004gtex_brain_ba24
rs20721421672132713HPENSG00000257017.41.541E-6042653gtex_brain_ba24
rs20746271672136769HPENSG00000257017.41.541E-6046709gtex_brain_ba24
rs127089281672137227HPENSG00000257017.41.541E-6047167gtex_brain_ba24
rs22402431672137561HPENSG00000257017.41.541E-6047501gtex_brain_ba24
rs123251421672138112HPENSG00000257017.41.541E-6048052gtex_brain_ba24
rs20746261672139184HPENSG00000257017.41.541E-6049124gtex_brain_ba24
rs22879971672140553HPENSG00000257017.43.815E-8050493gtex_brain_ba24
rs99261561672142895HPENSG00000257017.44.705E-6052835gtex_brain_ba24
rs22414121672144284HPENSG00000257017.44.678E-6054224gtex_brain_ba24
rs124483151672147242HPENSG00000257017.41.161E-6057182gtex_brain_ba24
rs64995601672147666HPENSG00000257017.41.155E-6057606gtex_brain_ba24
rs80473771672148339HPENSG00000257017.44.511E-6058279gtex_brain_ba24
rs124454011672148419HPENSG00000257017.42.939E-8058359gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0003824catalytic activityIEA-
GO:0030492hemoglobin bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006952defense responseTAS7036344 
GO:0006879cellular iron ion homeostasisNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005576extracellular regionNAS14718574 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN 14383All SZGR 2.0 genes in this pathway
LOPEZ MESOTELIOMA SURVIVAL TIME DN 77All SZGR 2.0 genes in this pathway
BOGNI TREATMENT RELATED MYELOID LEUKEMIA UP 3019All SZGR 2.0 genes in this pathway
LOPEZ MESOTHELIOMA SURVIVAL WORST VS BEST DN 76All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN 16193All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP 9858All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK DN 3927All SZGR 2.0 genes in this pathway
WONG ENDMETRIUM CANCER UP 2517All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION DN 10064All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 12792All SZGR 2.0 genes in this pathway
LI LUNG CANCER 4130All SZGR 2.0 genes in this pathway
HOUSTIS ROS 3629All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
NADLER OBESITY DN 4834All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 12690All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF UP 1210All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF TROGLITAZONE UP 1711All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 9671All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189112All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 15692All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING UP 5636All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS UP 9356All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252155All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D DN 4934All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP 10166All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 6850All SZGR 2.0 genes in this pathway
KAMIKUBO MYELOID CEBPA NETWORK 2819All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
STEGER ADIPOGENESIS UP 2116All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
VERNOCHET ADIPOGENESIS 1911All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP 14996All SZGR 2.0 genes in this pathway