Summary ?
GeneID325
SymbolAPCS
SynonymsHEL-S-92n|PTX2|SAP
Descriptionamyloid P component, serum
ReferenceMIM:104770|HGNC:HGNC:584|Ensembl:ENSG00000132703|HPRD:00101|Vega:OTTHUMG00000022741
Gene typeprotein-coding
Map location1q21-q23

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.0235 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ILF20.970.96
EIF3F0.970.95
QARS0.960.95
EIF3L0.960.95
EIF3D0.960.93
SNRNP400.960.93
NUP880.960.94
PCBP20.960.94
RBMX0.950.94
SSR20.950.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.70-0.88
AF347015.33-0.69-0.89
HLA-F-0.69-0.78
AF347015.31-0.69-0.85
MT-CO2-0.69-0.86
MT-CYB-0.69-0.88
AIFM3-0.68-0.77
AF347015.8-0.67-0.88
C5orf53-0.67-0.73
AF347015.15-0.66-0.88

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005529sugar bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0051082unfolded protein bindingTAS10812074 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006457protein foldingTAS10812074 
GO:0006953acute-phase responseTAS2987268 
GO:0051131chaperone-mediated protein complex assemblyTAS10972085 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
GO:0005615extracellular spaceTAS10972085 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME AMYLOIDS 8363All SZGR 2.0 genes in this pathway
FUJIWARA PARK2 HEPATOCYTE PROLIFERATION UP 108All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 6440All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP 6042All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA UP 6040All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
SU LIVER 5532All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 DN 228114All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
CHEN LIVER METABOLISM QTL CIS 9340All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN 7651All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210141All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA POOR SURVIVAL 169All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway