Gene Page: HRAS
Summary ?
| GeneID | 3265 |
| Symbol | HRAS |
| Synonyms | C-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|RASH1|p21ras |
| Description | Harvey rat sarcoma viral oncogene homolog |
| Reference | MIM:190020|HGNC:HGNC:5173|Ensembl:ENSG00000174775|HPRD:01813|Vega:OTTHUMG00000131919 |
| Gene type | protein-coding |
| Map location | 11p15.5 |
| Pascal p-value | 0.095 |
| Sherlock p-value | 0.76 |
| Fetal beta | -0.557 |
| eGene | Cerebellum Cortex Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
| Support | INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 3 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0119 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2809658 | chr1 | 43050395 | HRAS | 3265 | 0.1 | trans | ||
| rs61876339 | 11 | 495283 | HRAS | ENSG00000174775.12 | 1.78941E-6 | 0.01 | 42004 | gtex_brain_putamen_basal |
| rs12807963 | 11 | 518280 | HRAS | ENSG00000174775.12 | 7.20226E-7 | 0.01 | 19007 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0003924 | GTPase activity | IEA | - | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0005525 | GTP binding | IEA | - | |
| GO:0008022 | protein C-terminus binding | IPI | 9219684 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0048169 | regulation of long-term neuronal synaptic plasticity | IEA | neuron, Synap (GO term level: 10) | - |
| GO:0032228 | regulation of synaptic transmission, GABAergic | IEA | neuron, GABA, Synap, Neurotransmitter (GO term level: 9) | - |
| GO:0043524 | negative regulation of neuron apoptosis | IEA | neuron (GO term level: 9) | - |
| GO:0007265 | Ras protein signal transduction | EXP | 11520933 | |
| GO:0007265 | Ras protein signal transduction | IEA | - | |
| GO:0009887 | organ morphogenesis | TAS | 10848592 | |
| GO:0007166 | cell surface receptor linked signal transduction | TAS | 9020890 | |
| GO:0008284 | positive regulation of cell proliferation | IEA | - | |
| GO:0008542 | visual learning | IEA | - | |
| GO:0007569 | cell aging | IEA | - | |
| GO:0006935 | chemotaxis | TAS | 10848592 | |
| GO:0007264 | small GTPase mediated signal transduction | IEA | - | |
| GO:0006897 | endocytosis | IEA | - | |
| GO:0030036 | actin cytoskeleton organization | IEA | - | |
| GO:0035022 | positive regulation of Rac protein signal transduction | IEA | - | |
| GO:0051146 | striated muscle cell differentiation | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0000139 | Golgi membrane | IEA | - | |
| GO:0005794 | Golgi apparatus | IEA | - | |
| GO:0005622 | intracellular | IEA | - | |
| GO:0005624 | membrane fraction | IEA | - | |
| GO:0005737 | cytoplasm | TAS | 10842192 | |
| GO:0005886 | plasma membrane | EXP | 7972015 |8493579 |9069260 |9690470 | |
| GO:0005886 | plasma membrane | TAS | 9020890 |9880516 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| APBB1IP | INAG1 | PREL1 | RARP1 | RIAM | amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein | RIAM interacts with Ras. | BIND | 15469846 |
| ARAF | A-RAF | ARAF1 | PKS2 | RAFA1 | v-raf murine sarcoma 3611 viral oncogene homolog | ARAF (A-Raf) interacts with an unspecified isoform of HRAS (Ha-Ras). | BIND | 12620389 |
| ARHGEF1 | GEF1 | LBCL2 | LSC | P115-RHOGEF | SUB1.5 | Rho guanine nucleotide exchange factor (GEF) 1 | Biochemical Activity | BioGRID | 12581858 |
| BCL2 | Bcl-2 | B-cell CLL/lymphoma 2 | - | HPRD | 10490827 |
| BRAF | B-RAF1 | BRAF1 | FLJ95109 | MGC126806 | MGC138284 | RAFB1 | v-raf murine sarcoma viral oncogene homolog B1 | - | HPRD,BioGRID | 7706312 |
| BRAP | BRAP2 | IMP | RNF52 | BRCA1 associated protein | IMP interacts with Ras. | BIND | 14724641 |
| CDC25A | CDC25A2 | cell division cycle 25 homolog A (S. pombe) | - | HPRD | 7744247 |
| DGKZ | DAGK5 | DAGK6 | DGK-ZETA | hDGKzeta | diacylglycerol kinase, zeta 104kDa | - | HPRD,BioGRID | 11257115 |
| ERBB2IP | ERBIN | LAP2 | erbb2 interacting protein | - | HPRD,BioGRID | 12379659 |
| GPSM2 | LGN | Pins | G-protein signaling modulator 2 (AGS3-like, C. elegans) | - | HPRD,BioGRID | 12748287 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD | 11352655 |
| GRIN1 | NMDA1 | NMDAR1 | NR1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | - | HPRD | 10862698 |
| IKZF3 | AIO | AIOLOS | ZNFN1A3 | IKAROS family zinc finger 3 (Aiolos) | - | HPRD,BioGRID | 10369681 |
| INSR | CD220 | HHF5 | insulin receptor | - | HPRD,BioGRID | 3109943 |
| IRAK1 | IRAK | pelle | interleukin-1 receptor-associated kinase 1 | - | HPRD | 11744690 |
| IRAK2 | IRAK-2 | MGC150550 | interleukin-1 receptor-associated kinase 2 | - | HPRD | 11744690 |
| LGALS1 | DKFZp686E23103 | GAL1 | GBP | lectin, galactoside-binding, soluble, 1 | - | HPRD,BioGRID | 11709720 |
| MAP2K1 | MAPKK1 | MEK1 | MKK1 | PRKMK1 | mitogen-activated protein kinase kinase 1 | - | HPRD,BioGRID | 7969158 |
| MAPK8 | JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1 | mitogen-activated protein kinase 8 | - | HPRD | 8137421 |11525649 |
| MLLT4 | AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | - | HPRD,BioGRID | 10922060 |
| NF1 | DKFZp686J1293 | FLJ21220 | NFNS | VRNF | WSS | neurofibromin 1 | - | HPRD,BioGRID | 8628317 |
| PDE6D | PDED | phosphodiesterase 6D, cGMP-specific, rod, delta | - | HPRD,BioGRID | 11980706 |
| PDGFB | FLJ12858 | PDGF2 | SIS | SSV | c-sis | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | - | HPRD | 10485711 |
| PIK3CA | MGC142161 | MGC142163 | PI3K | p110-alpha | phosphoinositide-3-kinase, catalytic, alpha polypeptide | - | HPRD | 9150145 |
| PIK3CA | MGC142161 | MGC142163 | PI3K | p110-alpha | phosphoinositide-3-kinase, catalytic, alpha polypeptide | Reconstituted Complex Two-hybrid | BioGRID | 8665852 |10783161 |14724584 |
| PIK3CD | p110D | phosphoinositide-3-kinase, catalytic, delta polypeptide | Two-hybrid | BioGRID | 10922060 |
| PIK3CG | PI3CG | PI3K | PI3Kgamma | PIK3 | phosphoinositide-3-kinase, catalytic, gamma polypeptide | - | HPRD,BioGRID | 11136978 |
| PIK3R1 | GRB1 | p85 | p85-ALPHA | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | - | HPRD,BioGRID | 10212255 |
| PLAU | ATF | UPA | URK | UROKINASE | u-PA | plasminogen activator, urokinase | Phenotypic Suppression | BioGRID | 10402467 |
| RABAC1 | PRA1 | PRAF1 | YIP3 | Rab acceptor 1 (prenylated) | - | HPRD | 11335720 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | - | HPRD | 8530446 |8911690 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | Hras interacts with Raf. This interaction was modelled on a demonstrated interaction between Hras and Raf, both from an unspecified species. | BIND | 15705808 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | Raf interacts with Ras. This interaction was modeled on a demonstrated interaction between human Raf and rat Ras. | BIND | 11585923 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | RAF1 (C-Raf) interacts with HRAS (Ha-Ras). | BIND | 12620389 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | Raf-1 interacts with Ras. | BIND | 15664191 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | C-RAF interacts with Ha-Ras. | BIND | 12620389 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | Raf interacts with Ras. This interaction was modeled on a demonstrated interaction between Raf and an unspecified source and human Ras. | BIND | 7523381 |8307946 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 7862125 |7969158 |8530446 |8628317 |9150145 |9154803 |9523700 |10369681 |10783161 |10882715 |10922060 |12379659 |12620389 |14654780 |14724584 |15031288 |16803888 |
| RALA | MGC48949 | RAL | v-ral simian leukemia viral oncogene homolog A (ras related) | Two-hybrid | BioGRID | 11786539 |
| RALGDS | FLJ20922 | RGF | RalGEF | ral guanine nucleotide dissociation stimulator | Ras interacts with the carboxy terminus of RalGDS. This interaction was modeled on a demonstrated interaction between human Ras and rat RalGDS. | BIND | 9516482 |
| RALGDS | FLJ20922 | RGF | RalGEF | ral guanine nucleotide dissociation stimulator | Reconstituted Complex Two-hybrid | BioGRID | 7809086 |7972015 |9038168 |9150145 |10783161 |10922060 |15031288 |
| RALGDS | FLJ20922 | RGF | RalGEF | ral guanine nucleotide dissociation stimulator | - | HPRD | 7972015|9038168 |
| RAP1GDS1 | GDS1 | MGC118859 | MGC118861 | SmgGDS | RAP1, GTP-GDP dissociation stimulator 1 | - | HPRD,BioGRID | 11948427 |
| RASA1 | CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAP | RAS p21 protein activator (GTPase activating protein) 1 | - | HPRD,BioGRID | 7628625 |9219684 |
| RASA1 | CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAP | RAS p21 protein activator (GTPase activating protein) 1 | - | HPRD | 2833817 |7628625 |8663024 |9219684 |
| RASGRF1 | CDC25 | CDC25L | GNRP | GRF1 | GRF55 | H-GRF55 | PP13187 | Ras protein-specific guanine nucleotide-releasing factor 1 | Two-hybrid | BioGRID | 9154803 |
| RASGRP4 | - | RAS guanyl releasing protein 4 | - | HPRD | 11880369 |
| RASIP1 | FLJ20401 | RAIN | Ras interacting protein 1 | - | HPRD,BioGRID | 15031288 |
| RASSF1 | 123F2 | NORE2A | RASSF1A | RDA32 | REH3P21 | Ras association (RalGDS/AF-6) domain family member 1 | - | HPRD,BioGRID | 10998413 |
| RASSF2 | DKFZp781O1747 | KIAA0168 | RASFADIN | Ras association (RalGDS/AF-6) domain family member 2 | - | HPRD | 12732644 |
| RASSF5 | MGC10823 | MGC17344 | Maxp1 | NORE1 | NORE1A | NORE1B | RAPL | RASSF3 | Ras association (RalGDS/AF-6) domain family member 5 | Reconstituted Complex | BioGRID | 9488663 |
| RGL2 | HKE1.5 | KE1.5 | RAB2L | ral guanine nucleotide dissociation stimulator-like 2 | Reconstituted Complex Two-hybrid | BioGRID | 8939933 |15031288 |
| RGL4 | MGC119678 | MGC119680 | Rgr | ral guanine nucleotide dissociation stimulator-like 4 | - | HPRD,BioGRID | 12874025 |
| RHEB | MGC111559 | RHEB2 | Ras homolog enriched in brain | Affinity Capture-Western | BioGRID | 15854902 |
| RIN1 | - | Ras and Rab interactor 1 | Reconstituted Complex Two-hybrid | BioGRID | 7862125 |15031288 |
| RIN1 | - | Ras and Rab interactor 1 | - | HPRD | 7862125 |9144171 |
| SHOC2 | FLJ60412 | KIAA0862 | SIAA0862 | SOC-2 | SOC2 | SUR-8 | SUR8 | soc-2 suppressor of clear homolog (C. elegans) | - | HPRD,BioGRID | 9674433 |10783161 |
| SOS1 | GF1 | GGF1 | GINGF | HGF | NS4 | son of sevenless homolog 1 (Drosophila) | - | HPRD | 9690470 |11560935 |
| SOS1 | GF1 | GGF1 | GINGF | HGF | NS4 | son of sevenless homolog 1 (Drosophila) | Co-crystal Structure | BioGRID | 9690470 |12628188 |
| SOS2 | FLJ25596 | son of sevenless homolog 2 (Drosophila) | - | HPRD | 12628188 |
| TIAM1 | FLJ36302 | T-cell lymphoma invasion and metastasis 1 | - | HPRD,BioGRID | 12134164 |
| TTC1 | FLJ46404 | TPR1 | tetratricopeptide repeat domain 1 | - | HPRD,BioGRID | 12748287 |
| VAV1 | VAV | vav 1 guanine nucleotide exchange factor | - | HPRD | 8554611 |
| ZBTB12 | Bat9 | C6orf46 | D6S59E | G10 | NG35 | zinc finger and BTB domain containing 12 | - | HPRD | 8939933 |