Gene Page: HRC
Summary ?
| GeneID | 3270 |
| Symbol | HRC |
| Synonyms | - |
| Description | histidine rich calcium binding protein |
| Reference | MIM:142705|HGNC:HGNC:5178|Ensembl:ENSG00000130528|HPRD:00818|Vega:OTTHUMG00000183203 |
| Gene type | protein-coding |
| Map location | 19q13.3 |
| Pascal p-value | 0.029 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16869851 | chr4 | 20690056 | HRC | 3270 | 0.1 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CNDP1 | 0.82 | 0.76 |
| SYNJ2 | 0.82 | 0.64 |
| PRUNE2 | 0.81 | 0.79 |
| LGI3 | 0.79 | 0.85 |
| ENDOD1 | 0.78 | 0.72 |
| GLDN | 0.78 | 0.78 |
| SYT2 | 0.78 | 0.53 |
| SEC14L5 | 0.78 | 0.82 |
| ERMP1 | 0.78 | 0.67 |
| VAMP1 | 0.77 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TBC1D10A | -0.44 | -0.49 |
| OLFM2 | -0.41 | -0.47 |
| WDR86 | -0.41 | -0.49 |
| BCL7C | -0.40 | -0.66 |
| NKIRAS2 | -0.39 | -0.52 |
| SH3BP2 | -0.39 | -0.69 |
| SH2B2 | -0.39 | -0.72 |
| MMP25 | -0.39 | -0.58 |
| KIAA1949 | -0.38 | -0.62 |
| TUBB2B | -0.38 | -0.67 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KIM WT1 TARGETS 12HR DN | 209 | 122 | All SZGR 2.0 genes in this pathway |
| DARWICHE SKIN TUMOR PROMOTER DN | 185 | 115 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK LOW UP | 162 | 104 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK HIGH UP | 147 | 101 | All SZGR 2.0 genes in this pathway |
| DARWICHE SQUAMOUS CELL CARCINOMA UP | 146 | 104 | All SZGR 2.0 genes in this pathway |
| DELASERNA MYOD TARGETS UP | 89 | 51 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL CARCINOMA VS ADENOMA DN | 24 | 18 | All SZGR 2.0 genes in this pathway |
| JUBAN TARGETS OF SPI1 AND FLI1 DN | 92 | 60 | All SZGR 2.0 genes in this pathway |