Gene Page: HRG
Summary ?
| GeneID | 3273 |
| Symbol | HRG |
| Synonyms | HPRG|HRGP|THPH11 |
| Description | histidine rich glycoprotein |
| Reference | MIM:142640|HGNC:HGNC:5181|Ensembl:ENSG00000113905|HPRD:00812|Vega:OTTHUMG00000156578 |
| Gene type | protein-coding |
| Map location | 3q27 |
| Pascal p-value | 0.925 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CERCAM | 0.77 | 0.54 |
| CD22 | 0.76 | 0.79 |
| AC110285.2 | 0.73 | 0.75 |
| AC024575.3 | 0.72 | 0.74 |
| HPN | 0.71 | 0.78 |
| PLA2G16 | 0.71 | 0.78 |
| AC087645.1 | 0.70 | 0.78 |
| SEPT4 | 0.70 | 0.75 |
| COL16A1 | 0.70 | 0.70 |
| ZFP57 | 0.70 | 0.74 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PURG | -0.51 | -0.68 |
| PPP3CC | -0.50 | -0.68 |
| CDC42 | -0.50 | -0.69 |
| MLLT11 | -0.49 | -0.69 |
| SMAP1 | -0.49 | -0.67 |
| MGAT2 | -0.49 | -0.68 |
| C7orf70 | -0.48 | -0.66 |
| NKIRAS2 | -0.48 | -0.70 |
| TUBB2A | -0.48 | -0.67 |
| SMAD1 | -0.48 | -0.67 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | 89 | 56 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | 208 | 138 | All SZGR 2.0 genes in this pathway |
| CERVERA SDHB TARGETS 1 UP | 118 | 66 | All SZGR 2.0 genes in this pathway |
| HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
| KAYO AGING MUSCLE UP | 244 | 165 | All SZGR 2.0 genes in this pathway |
| YAMASHITA LIVER CANCER STEM CELL DN | 76 | 51 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
| OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS DN | 157 | 105 | All SZGR 2.0 genes in this pathway |
| NABA ECM REGULATORS | 238 | 125 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |