SZGR2

Summary ?

GeneID	3276
Symbol	PRMT1
Synonyms	ANM1\|HCP1\|HRMT1L2\|IR1B4
Description	protein arginine methyltransferase 1
Reference	MIM:602950\|HGNC:HGNC:5187\|Ensembl:ENSG00000126457\|HPRD:04257\|Vega:OTTHUMG00000167568
Gene type	protein-coding
Map location	19q13.3
Pascal p-value	1.215E-5
Sherlock p-value	8.185E-5
Fetal beta	0.678
eGene	Caudate basal ganglia Myers' cis & trans
Support	Chromatin Remodeling Genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs443832	chr16	83779643	PRMT1	3276		0.15		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Reconstituted Complex	BioGRID	11050077
ARPC3	ARC21 \| p21-Arc	actin related protein 2/3 complex, subunit 3, 21kDa	Two-hybrid	BioGRID	16169070
BTG1	-	B-cell translocation gene 1, anti-proliferative	Reconstituted Complex Two-hybrid	BioGRID	8663146 \|11856371
BTG1	-	B-cell translocation gene 1, anti-proliferative	BTG1 interacts with HRMT1L2 (PRMT1). This interaction was modeled on a demonstrated interaction between human BTG1 and PRMT1 from an unspecified species.	BIND	15674337
BTG1	-	B-cell translocation gene 1, anti-proliferative	-	HPRD	8663146 \|14734530
BTG2	MGC126063 \| MGC126064 \| PC3 \| TIS21	BTG family, member 2	-	HPRD,BioGRID	11856371
BTG2	MGC126063 \| MGC126064 \| PC3 \| TIS21	BTG family, member 2	-	HPRD	8663146 \|11856371\|11856371
C1orf103	FLJ11269 \| RIF1 \| RP11-96K19.1	chromosome 1 open reading frame 103	Two-hybrid	BioGRID	16169070
CAPRIN1	GPIAP1 \| GPIP137 \| M11S1 \| caprin-1 \| p137GPI	cell cycle associated protein 1	Biochemical Activity	BioGRID	12183049
CARM1	PRMT4	coactivator-associated arginine methyltransferase 1	Phenotypic Enhancement	BioGRID	11050077
CIRBP	CIRP	cold inducible RNA binding protein	-	HPRD,BioGRID	11850402
DHX9	DDX9 \| LKP \| NDHII \| RHA	DEAH (Asp-Glu-Ala-His) box polypeptide 9	-	HPRD,BioGRID	11850402 \|15084609
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Reconstituted Complex	BioGRID	11050077
FBL	FIB \| FLRN \| RNU3IP1	fibrillarin	-	HPRD,BioGRID	14583623
FUS	CHOP \| FUS-CHOP \| FUS1 \| TLS \| TLS/CHOP \| hnRNP-P2	fusion (involved in t(12;16) in malignant liposarcoma)	-	HPRD,BioGRID	11850402
HABP4	IHABP4 \| Ki-1/57 \| MGC825 \| SERBP1L	hyaluronan binding protein 4	Two-hybrid	BioGRID	16169070
HNRNPA1	HNRPA1 \| MGC102835	heterogeneous nuclear ribonucleoprotein A1	Biochemical Activity	BioGRID	8663146
HNRNPK	CSBP \| FLJ41122 \| HNRPK \| TUNP	heterogeneous nuclear ribonucleoprotein K	-	HPRD,BioGRID	12529443
HNRNPR	FLJ25714 \| HNRPR \| hnRNP-R	heterogeneous nuclear ribonucleoprotein R	-	HPRD,BioGRID	12183049
HNRNPU	HNRPU \| SAF-A \| U21.1	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	-	HPRD,BioGRID	11850402
HNRNPUL1	E1B-AP5 \| E1BAP5 \| FLJ12944 \| HNRPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	Biochemical Activity	BioGRID	11513728
IFNAR1	AVP \| IFN-alpha-REC \| IFNAR \| IFNBR \| IFRC	interferon (alpha, beta and omega) receptor 1	-	HPRD,BioGRID	9029147
IGSF21	FLJ41177 \| MGC15730	immunoglobin superfamily, member 21	Two-hybrid	BioGRID	16169070
ILF3	CBTF \| DRBF \| DRBP76 \| MMP4 \| MPHOSPH4 \| MPP4 \| NF-AT-90 \| NF110 \| NF90 \| NFAR \| NFAR-1 \| NFAR2 \| TCP110 \| TCP80	interleukin enhancer binding factor 3, 90kDa	-	HPRD,BioGRID	10749851
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	-	HPRD,BioGRID	12529443
KHDRBS3	Etle \| SALP \| SLM-2 \| SLM2 \| T-STAR \| TSTAR \| etoile	KH domain containing, RNA binding, signal transduction associated 3	-	HPRD,BioGRID	12529443
MED31	3110004H13Rik \| CGI-125 \| FLJ27436 \| FLJ36714 \| Soh1	mediator complex subunit 31	Two-hybrid	BioGRID	16169070
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD,BioGRID	11050077
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	-	HPRD,BioGRID	11050077
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	-	HPRD,BioGRID	11050077
PRMT1	ANM1 \| HCP1 \| HRMT1L2 \| IR1B4	protein arginine methyltransferase 1	-	HPRD,BioGRID	12737817
QKI	DKFZp586I0923 \| Hqk \| QK \| QK1 \| QK3	quaking homolog, KH domain RNA binding (mouse)	-	HPRD	12529443
S100A8	60B8AG \| CAGA \| CFAG \| CGLA \| CP-10 \| L1Ag \| MA387 \| MIF \| MRP8 \| NIF \| P8	S100 calcium binding protein A8	Two-hybrid	BioGRID	16169070
SSSCA1	p27	Sjogren syndrome/scleroderma autoantigen 1	Affinity Capture-MS	BioGRID	17353931
SUPT5H	FLJ34157 \| SPT5 \| SPT5H	suppressor of Ty 5 homolog (S. cerevisiae)	-	HPRD,BioGRID	12718890
SYNCRIP	GRY-RBP \| HNRPQ1 \| NSAP1 \| RP1-3J17.2 \| dJ3J17.2 \| hnRNP-Q \| pp68	synaptotagmin binding, cytoplasmic RNA interacting protein	Biochemical Activity	BioGRID	12183049
TAF15	Npl3 \| RBP56 \| TAF2N \| TAFII68 \| hTAFII68	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	Biochemical Activity	BioGRID	12183049
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	Reconstituted Complex	BioGRID	11050077
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	15186775
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	PRMT1 interacts with p53. This interaction was modeled on a demonstrated interaction between rat PRMT1 and human p53.	BIND	15186775
WDR33	FLJ11294 \| WDC146	WD repeat domain 33	Two-hybrid	BioGRID	16169070
YLPM1	C14orf170 \| ZAP \| ZAP3	YLP motif containing 1	Two-hybrid	BioGRID	16169070
ZFP161	MGC126126 \| ZBTB14 \| ZF5 \| ZNF478	zinc finger protein 161 homolog (mouse)	Biochemical Activity	BioGRID	12183049

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES DN	16	10	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN	136	94	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS AND SERUM RESPONSE UP	47	32	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY UP	121	71	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN	57	45	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP	151	100	All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN	85	56	All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN	245	154	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP	65	44	All SZGR 2.0 genes in this pathway
XU CREBBP TARGETS UP	26	16	All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 DN	15	12	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS UP	66	43	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV	63	44	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP	125	89	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN	45	31	All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS UP	112	71	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP	298	174	All SZGR 2.0 genes in this pathway
LEE RECENT THYMIC EMIGRANT	227	128	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14	143	86	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway

Gene Page: PRMT1