SZGR2

Summary ?

GeneID	3297
Symbol	HSF1
Synonyms	HSTF1
Description	heat shock transcription factor 1
Reference	MIM:140580\|HGNC:HGNC:5224\|Ensembl:ENSG00000185122\|HPRD:00778\|Vega:OTTHUMG00000174604
Gene type	protein-coding
Map location	8q24.3
Pascal p-value	0.39
Sherlock p-value	0.32
Fetal beta	0.147

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CEBPB	C/EBP-beta \| CRP2 \| IL6DBP \| LAP \| MGC32080 \| NF-IL6 \| TCF5	CCAAT/enhancer binding protein (C/EBP), beta	-	HPRD,BioGRID	11801594
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	HSF1 interacts with CBP. This interaction was modeled on a demonstrated interaction between human HSF1 and CBP from an unspecified species.	BIND	14960326
DNAJB1	HSPF1 \| Hdj1 \| Hsp40 \| Sis1	DnaJ (Hsp40) homolog, subfamily B, member 1	-	HPRD,BioGRID	9499401
ENO2	NSE	enolase 2 (gamma, neuronal)	Two-hybrid	BioGRID	16169070
FKBP4	FKBP52 \| FKBP59 \| HBI \| Hsp56 \| PPIase \| p52	FK506 binding protein 4, 59kDa	Reconstituted Complex	BioGRID	9222609
FKBP5	FKBP51 \| FKBP54 \| MGC111006 \| P54 \| PPIase \| Ptg-10	FK506 binding protein 5	Reconstituted Complex	BioGRID	9222609
GTF2A2	HsT18745 \| TF2A2 \| TFIIA	general transcription factor IIA, 2, 12kDa	-	HPRD	11005381
GTF2B	TF2B \| TFIIB	general transcription factor IIB	Reconstituted Complex	BioGRID	11005381
HSBP1	DKFZp686D1664 \| DKFZp686O24200 \| NPC-A-13	heat shock factor binding protein 1	in vitro in vivo Two-hybrid	BioGRID	9649501
HSF2	MGC117376 \| MGC156196 \| MGC75048	heat shock transcription factor 2	-	HPRD,BioGRID	12813038
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9222609 \|12621024
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	-	HPRD,BioGRID	9699716
HSPA4	APG-2 \| HS24/P52 \| MGC131852 \| RY \| hsp70 \| hsp70RY	heat shock 70kDa protein 4	Reconstituted Complex	BioGRID	1628823 \|9222609
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD,BioGRID	7639722
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	ERK1 interacts with and phosphorylates HSF-1.	BIND	9155018
MAPK9	JNK-55 \| JNK2 \| JNK2A \| JNK2ALPHA \| JNK2B \| JNK2BETA \| PRKM9 \| SAPK \| p54a \| p54aSAPK	mitogen-activated protein kinase 9	-	HPRD,BioGRID	11527157
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Affinity Capture-Western Co-localization	BioGRID	14960326
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	ASC-2 interacts with HSF1.	BIND	14960326
PPID	CYP-40 \| CYPD \| MGC33096	peptidylprolyl isomerase D	Reconstituted Complex	BioGRID	9222609
PRKDC	DNA-PKcs \| DNAPK \| DNPK1 \| HYRC \| HYRC1 \| XRCC7 \| p350	protein kinase, DNA-activated, catalytic polypeptide	in vitro	BioGRID	9325337
PTGES3	P23 \| TEBP \| cPGES	prostaglandin E synthase 3 (cytosolic)	Reconstituted Complex	BioGRID	9222609
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12621024
SMARCA4	BAF190 \| BRG1 \| FLJ39786 \| SNF2 \| SNF2-BETA \| SNF2L4 \| SNF2LB \| SWI2 \| hSNF2b	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Affinity Capture-Western in vitro	BioGRID	8856972 \|11486022
SMARCA4	BAF190 \| BRG1 \| FLJ39786 \| SNF2 \| SNF2-BETA \| SNF2L4 \| SNF2LB \| SWI2 \| hSNF2b	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	-	HPRD	8856972 \|9222609 \|11486022
SMARCB1	BAF47 \| INI1 \| RDT \| SNF5 \| SNF5L1 \| Sfh1p \| Snr1 \| hSNFS	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Co-fractionation	BioGRID	11486022
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD,BioGRID	9880553
SUB1	MGC102747 \| P15 \| PC4 \| p14	SUB1 homolog (S. cerevisiae)	-	HPRD	11005381
SYMPK	FLJ27092 \| SPK \| SYM	symplekin	-	HPRD,BioGRID	14707147
TAF1	BA2R \| CCG1 \| CCGS \| DYT3 \| KAT4 \| N-TAF1 \| NSCL2 \| OF \| P250 \| TAF2A \| TAFII250	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	-	HPRD	11005381
TAF9	AD-004 \| AK6 \| CGI-137 \| CINAP \| CIP \| MGC1603 \| MGC3647 \| MGC5067 \| MGC:1603 \| MGC:3647 \| MGC:5067 \| TAF2G \| TAFII31 \| TAFII32 \| TAFIID32	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	-	HPRD	11005381
TAF9	AD-004 \| AK6 \| CGI-137 \| CINAP \| CIP \| MGC1603 \| MGC3647 \| MGC5067 \| MGC:1603 \| MGC:3647 \| MGC:5067 \| TAF2G \| TAFII31 \| TAFII32 \| TAFIID32	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	-	HPRD	10821850
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	-	HPRD,BioGRID	11005381
XRCC5	FLJ39089 \| KARP-1 \| KARP1 \| KU80 \| KUB2 \| Ku86 \| NFIV	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	in vitro	BioGRID	9325337
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	-	HPRD,BioGRID	11162511

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN	384	220	All SZGR 2.0 genes in this pathway
TIMOFEEVA GROWTH STRESS VIA STAT1 DN	16	12	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP	238	144	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP	114	66	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN	146	94	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION	77	51	All SZGR 2.0 genes in this pathway
TURJANSKI MAPK8 AND MAPK9 TARGETS	8	7	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A UP	77	49	All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED	100	68	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON	157	87	All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA DN	11	6	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN	141	92	All SZGR 2.0 genes in this pathway
MATZUK MATERNAL EFFECT	9	8	All SZGR 2.0 genes in this pathway
MATZUK POST-IMPLANTATION AND POST-PARTUM	14	13	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE	72	55	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway

Gene Page: HSF1