Gene Page: BIRC3

Summary ?
GeneID330
SymbolBIRC3
SynonymsAIP1|API2|CIAP2|HAIP1|HIAP1|MALT2|MIHC|RNF49|c-IAP2
Descriptionbaculoviral IAP repeat containing 3
ReferenceMIM:601721|HGNC:HGNC:591|Ensembl:ENSG00000023445|HPRD:03426|Vega:OTTHUMG00000167324
Gene typeprotein-coding
Map location11q22
Pascal p-value0.551
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg2034672611101918403BIRC30.0046.993DMG:vanEijk_2014
cg1953113011101786659BIRC30.0055.369DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs11979332chr786581744BIRC33300.19trans
rs11219646chr11124279239BIRC33300.13trans
rs17342476chrX102243644BIRC33300.07trans
rs17342504chrX102272107BIRC33300.07trans
snp_a-21388510BIRC33300.07trans
snp_a-20599280BIRC33300.07trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TUBB40.900.91
RANGAP10.880.88
PNPLA60.860.86
ATP6AP10.850.86
IGSF80.850.84
DCTN10.840.87
GIT10.840.84
SEZ6L20.830.86
MAN2B20.830.85
CACNB10.830.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.58-0.42
AP002478.3-0.55-0.51
C1orf54-0.52-0.44
AF347015.18-0.52-0.39
GNG11-0.51-0.43
NSBP1-0.50-0.48
MT-CO2-0.50-0.37
SYCP3-0.50-0.51
AL050337.1-0.50-0.45
AF347015.8-0.49-0.36

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidasecIAP2 exhibits E3 ubiquitin ligase activity towards Casp3.BIND10862606 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD,BioGRID9384571 
CASP7CMH-1 | ICE-LAP3 | MCH3caspase 7, apoptosis-related cysteine peptidase-HPRD,BioGRID9384571 
CASP7CMH-1 | ICE-LAP3 | MCH3caspase 7, apoptosis-related cysteine peptidasecIAP2 exhibits E3 ubiquitin ligase activity towards Casp7.BIND10862606 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD,BioGRID9545235 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinaseThe cIAP-2 promoter interacts with IKK-alpha.BIND15494311 
DIABLODIABLO-S | FLJ10537 | FLJ25049 | SMAC | SMAC3diablo homolog (Drosophila)-HPRD,BioGRID10929712 
EP300KAT3B | p300E1A binding protein p300The cIAP-2 promoter interacts with p300.BIND15494311 
GSPT1551G9.2 | ETF3A | FLJ38048 | FLJ39067 | GST1 | eRF3aG1 to S phase transition 1-HPRD12865429 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3The cIAP-2 promoter interacts with HDAC3.BIND15494311 
HIST3H3H3.4 | H3/g | H3FT | H3t | MGC126886 | MGC126888histone cluster 3, H3The cIAP-2 promoter interacts with phosphorylated and/or acetylated H3.BIND15494311 
HTRA2OMI | PARK13 | PRSS25HtrA serine peptidase 2Reconstituted ComplexBioGRID12865429 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaThe cIAP-2 promoter interacts with IKK-beta.BIND15494311 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2The cIAP-2 promoter interacts with SMRT.BIND15494311 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1The cIAP-2 promoter interacts with p50.BIND15494311 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)The cIAP-2 promoter interacts with p65.BIND15494311 
RIPK2CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2receptor-interacting serine-threonine kinase 2Affinity Capture-WesternBioGRID9705938 
TP73P73tumor protein p73p73-alpha binds p53 AIP1 promoter.BIND15175157 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1-HPRD,BioGRID11907583 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1c-IAP2 interacts with TRAF1.BIND11907583 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD8643514 |11907583 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2in vitro
Reconstituted Complex
Two-hybrid		BioGRID8643514 |9384571 
|11907583 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2c-IAP2 interacts with TRAF2.BIND11907583 
UBE2D1E2(17)KB1 | SFT | UBC4/5 | UBCH5 | UBCH5Aubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)The cIAP-2 promoter interacts with Ubc5.BIND15494311 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideThe cIAP-2 promoter interacts with 14-3-3-epsilon.BIND15494311 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 13898All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 6247All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 8467All SZGR 2.0 genes in this pathway
BIOCARTA CASPASE PATHWAY 2315All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY 5843All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA MITOCHONDRIA PATHWAY 2115All SZGR 2.0 genes in this pathway
BIOCARTA SODD PATHWAY 107All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY 2920All SZGR 2.0 genes in this pathway
SA CASPASE CASCADE 1913All SZGR 2.0 genes in this pathway
PID CD40 PATHWAY 3126All SZGR 2.0 genes in this pathway
PID FAS PATHWAY 3829All SZGR 2.0 genes in this pathway
PID TNF PATHWAY 4633All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY 4837All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY 6951All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 8461All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY 3526All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY 5239All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY 3022All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 4633All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206111All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL DN 6039All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320184All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306188All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 7841All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457269All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238144All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN 9557All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN 7550All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378231All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID DN 6745All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 12678All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP 6940All SZGR 2.0 genes in this pathway
DUTTA APOPTOSIS VIA NFKB 3325All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 12792All SZGR 2.0 genes in this pathway
RASHI NFKB1 TARGETS 1918All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER HIGH RECURRENCE 4931All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 23 2413All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY 6648All SZGR 2.0 genes in this pathway
SNIJDERS AMPLIFIED IN HEAD AND NECK TUMORS 3727All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149101All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411249All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE DN 7749All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE DN 5839All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE UP 5335All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
ONDER CDH1 SIGNALING VIA CTNNB1 8358All SZGR 2.0 genes in this pathway
KLEIN PRIMARY EFFUSION LYMPHOMA DN 5842All SZGR 2.0 genes in this pathway
KANNAN TP53 TARGETS DN 2115All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
WONG IFNA2 RESISTANCE UP 1610All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 8356All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS 183115All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
STOSSI RESPONSE TO ESTRADIOL 5035All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 11484All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS 7147All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245144All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA DN 2314All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253147All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314188All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154101All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 11580All SZGR 2.0 genes in this pathway
OSADA ASCL1 TARGETS DN 2420All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
GALI TP53 TARGETS APOPTOTIC UP 87All SZGR 2.0 genes in this pathway
CHO NR4A1 TARGETS 3322All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223132All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
VILIMAS NOTCH1 TARGETS UP 5241All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP 7756All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION B 5336All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN 7247All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
ZHAN V1 LATE DIFFERENTIATION GENES UP 3225All SZGR 2.0 genes in this pathway
SCHOEN NFKB SIGNALING 3426All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
NOUSHMEHR GBM SILENCED BY METHYLATION 5032All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA VIA KDM3A 5334All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway
PHONG TNF TARGETS UP 6343All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway
GENTLES LEUKEMIC STEM CELL UP 2915All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 11068All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 8654All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222159All SZGR 2.0 genes in this pathway