SZGR2

Summary ?

GeneID	3312
Symbol	HSPA8
Synonyms	HEL-33\|HEL-S-72p\|HSC54\|HSC70\|HSC71\|HSP71\|HSP73\|HSPA10\|LAP-1\|LAP1\|NIP71
Description	heat shock protein family A (Hsp70) member 8
Reference	MIM:600816\|HGNC:HGNC:5241\|Ensembl:ENSG00000109971\|HPRD:07205\|Vega:OTTHUMG00000166030
Gene type	protein-coding
Map location	11q24.1
Pascal p-value	0.009
Sherlock p-value	0.831
TADA p-value	0.001
Fetal beta	1.299
eGene	Myers' cis & trans
Support	RNA AND PROTEIN SYNTHESIS CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DNM:Fromer_2014	Whole Exome Sequencing analysis	This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.006
Expression	Meta-analysis of gene expression	P value: 2.107
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Trait	Study
HSPA8	chr11	122929399	A	ATGCC	NM_006597 NM_006597 NM_153201	p.488> . .	indel frameshift intronic	Schizophrenia	DNM:Fromer_2014
HSPA8	chr11	122929444	T	C	NM_006597 NM_153201	p.473Q>R .	missense intronic	Schizophrenia	DNM:Fromer_2014
HSPA8	chr11	122929804	G	C	NM_006597 NM_153201	p.429T>S p.429T>S	missense missense	Schizophrenia	DNM:Fromer_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs6902183	chr6	121963786	HSPA8	3312		0.06		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005515	protein binding	IPI		10954706
GO:0005524	ATP binding	IEA		-
GO:0042623	ATPase activity, coupled	NAS		8530083
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006457	protein folding	NAS		8530083
GO:0006986	response to unfolded protein	NAS		11093761
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	NAS		8713105
GO:0005737	cytoplasm	IEA		-
GO:0009986	cell surface	IDA		12493773
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABI1	ABI-1 \| E3B1 \| NAP1BP \| SSH3BP \| SSH3BP1	abl-interactor 1	-	HPRD	15048123
ALDOB	-	aldolase B, fructose-bisphosphate	-	HPRD	11241348
APOB	FLDB	apolipoprotein B (including Ag(x) antigen)	-	HPRD	9694898
BAG1	RAP46	BCL2-associated athanogene	-	HPRD,BioGRID	9305631
BAG2	BAG-2 \| KIAA0576 \| MGC149462 \| dJ417I1.2	BCL2-associated athanogene 2	-	HPRD,BioGRID	9873016
BAG3	BAG-3 \| BIS \| CAIR-1 \| MGC104307	BCL2-associated athanogene 3	-	HPRD,BioGRID	9873016
BAG4	BAG-4 \| SODD	BCL2-associated athanogene 4	Reconstituted Complex	BioGRID	11909948
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Two-hybrid	BioGRID	9738006
C4orf14	MGC3232 \| hAtNOS1 \| mAtNOS1	chromosome 4 open reading frame 14	Two-hybrid	BioGRID	16169070
CCT3	CCT-gamma \| CCTG \| PIG48 \| TCP-1-gamma \| TRIC5	chaperonin containing TCP1, subunit 3 (gamma)	-	HPRD	10635329
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	Affinity Capture-Western	BioGRID	10075921
CITED1	MSG1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	-	HPRD,BioGRID	10722728
CLTA	LCA	clathrin, light chain (Lca)	-	HPRD	1975516
CYCS	CYC \| HCS	cytochrome c, somatic	-	HPRD,BioGRID	8663341
DNAJA1	DJ-2 \| DjA1 \| HDJ2 \| HSDJ \| HSJ2 \| HSPF4 \| hDJ-2	DnaJ (Hsp40) homolog, subfamily A, member 1	-	HPRD,BioGRID	10075921
DNAJA3	FLJ45758 \| TID1 \| hTid-1	DnaJ (Hsp40) homolog, subfamily A, member 3	-	HPRD,BioGRID	11679576 \|14993262
DNAJB1	HSPF1 \| Hdj1 \| Hsp40 \| Sis1	DnaJ (Hsp40) homolog, subfamily B, member 1	Reconstituted Complex	BioGRID	10075921
DNAJB1	HSPF1 \| Hdj1 \| Hsp40 \| Sis1	DnaJ (Hsp40) homolog, subfamily B, member 1	Hsp40 interacts with the carboxy-terminal region of Hsc70.	BIND	10330192
DNAJC2	MPHOSPH11 \| MPP11 \| ZRF1 \| ZUO1	DnaJ (Hsp40) homolog, subfamily C, member 2	Mpp11 interacts with an unspecified isoform of Hsc70.	BIND	15802566
DNAJC3	HP58 \| P58 \| P58IPK \| PRKRI	DnaJ (Hsp40) homolog, subfamily C, member 3	Affinity Capture-Western	BioGRID	11116152
ERH	DROER \| FLJ27340	enhancer of rudimentary homolog (Drosophila)	Two-hybrid	BioGRID	16169070
FANCC	FA3 \| FAC \| FACC \| FLJ14675	Fanconi anemia, complementation group C	Two-hybrid	BioGRID	14499622
FBP1	FBP	fructose-1,6-bisphosphatase 1	Two-hybrid	BioGRID	16169070
GAK	FLJ16629 \| FLJ40395 \| MGC99654	cyclin G associated kinase	-	HPRD	10625686
GOT2	FLJ40994 \| KAT4 \| KATIV \| mitAAT	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	-	HPRD,BioGRID	7559589
HCFC1	CFF \| HCF-1 \| HCF1 \| HFC1 \| MGC70925 \| VCAF	host cell factor C1 (VP16-accessory protein)	Affinity Capture-MS	BioGRID	12670868
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	-	HPRD,BioGRID	12502735
HSF1	HSTF1	heat shock transcription factor 1	-	HPRD,BioGRID	7639722
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD,BioGRID	9269769
HSPBP1	-	hsp70-interacting protein	-	HPRD	9830037
HSPBP1	-	hsp70-interacting protein	Two-hybrid	BioGRID	16169070 \|16189514
HSPH1	DKFZp686M05240 \| HSP105 \| HSP105A \| HSP105B \| KIAA0201 \| NY-CO-25	heat shock 105kDa/110kDa protein 1	-	HPRD	9675148
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	-	HPRD	14743216
IKBKE	IKK-i \| IKKE \| IKKI \| KIAA0151 \| MGC125294 \| MGC125295 \| MGC125297	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	-	HPRD	14743216
IKBKG	AMCBX1 \| FIP-3 \| FIP3 \| Fip3p \| IKK-gamma \| IP \| IP1 \| IP2 \| IPD2 \| NEMO	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	-	HPRD	14743216
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD,BioGRID	11679576
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	-	HPRD	14743216
MAP3K3	MAPKKK3 \| MEKK3	mitogen-activated protein kinase kinase kinase 3	-	HPRD	14743216
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD	14743216
MAP3K7IP1	3'-Tab1 \| MGC57664 \| TAB1	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	-	HPRD	14743216
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD	14743216
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	-	HPRD	14743216
NFKB2	LYT-10 \| LYT10	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	-	HPRD	14743216
NFKBIA	IKBA \| MAD-3 \| NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	-	HPRD	14743216
NFKBIB	IKBB \| TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	-	HPRD	14743216
NFKBIE	IKBE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	-	HPRD	14743216
POLR3D	BN51T \| RPC4 \| RPC53 \| TSBN51	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	Affinity Capture-MS	BioGRID	12391170
PPID	CYP-40 \| CYPD \| MGC33096	peptidylprolyl isomerase D	-	HPRD,BioGRID	15497503
PPP1CA	MGC15877 \| MGC1674 \| PP-1A \| PPP1A	protein phosphatase 1, catalytic subunit, alpha isoform	Affinity Capture-Western	BioGRID	9269769
PPP1R12B	MGC131980 \| MGC87886 \| MYPT2	protein phosphatase 1, regulatory (inhibitor) subunit 12B	Affinity Capture-Western	BioGRID	9269769
PPP1R15A	GADD34	protein phosphatase 1, regulatory (inhibitor) subunit 15A	Affinity Capture-Western	BioGRID	12724406
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	-	HPRD	7673249
RBX1	BA554C12.1 \| MGC13357 \| MGC1481 \| RNF75 \| ROC1	ring-box 1	Affinity Capture-MS	BioGRID	12481031
REL	C-Rel	v-rel reticuloendotheliosis viral oncogene homolog (avian)	-	HPRD	2155506
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD	14743216
RELB	I-REL \| IREL	v-rel reticuloendotheliosis viral oncogene homolog B	-	HPRD	14743216
RGS2	G0S8	regulator of G-protein signaling 2, 24kDa	Two-hybrid	BioGRID	16169070
RIPK1	FLJ39204 \| RIP \| RIP1	receptor (TNFRSF)-interacting serine-threonine kinase 1	-	HPRD	14743216
RIPK2	CARD3 \| CARDIAK \| CCK \| GIG30 \| RICK \| RIP2	receptor-interacting serine-threonine kinase 2	-	HPRD	14743216
RIPK3	RIP3	receptor-interacting serine-threonine kinase 3	-	HPRD	14743216
SP1	-	Sp1 transcription factor	-	HPRD	10976766
STMN1	LAP18 \| Lag \| OP18 \| PP17 \| PP19 \| PR22 \| SMN	stathmin 1/oncoprotein 18	-	HPRD,BioGRID	10197448
STUB1	CHIP \| HSPABP2 \| NY-CO-7 \| SDCCAG7 \| UBOX1	STIP1 homology and U-box containing protein 1	-	HPRD,BioGRID	10330192
STUB1	CHIP \| HSPABP2 \| NY-CO-7 \| SDCCAG7 \| UBOX1	STIP1 homology and U-box containing protein 1	The TPR and charged domains of CHIP interact with the carboxy-terminal region of Hsc70.	BIND	10330192
TADA3L	ADA3 \| FLJ20221 \| FLJ21329 \| hADA3	transcriptional adaptor 3 (NGG1 homolog, yeast)-like	Two-hybrid	BioGRID	16169070
TANK	I-TRAF \| TRAF2	TRAF family member-associated NFKB activator	-	HPRD	14743216
TBK1	FLJ11330 \| NAK \| T2K	TANK-binding kinase 1	-	HPRD	14743216
TCERG1	CA150 \| MGC133200 \| TAF2S	transcription elongation regulator 1	-	HPRD,BioGRID	15456888
TCP1	CCT-alpha \| CCT1 \| CCTa \| D6S230E \| TCP-1-alpha	t-complex 1	Reconstituted Complex	BioGRID	10075921
TM4SF1	H-L6 \| L6 \| M3S1 \| TAAL6	transmembrane 4 L six family member 1	Two-hybrid	BioGRID	16169070
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	tumor necrosis factor receptor superfamily, member 1A	-	HPRD,BioGRID	11909948
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	tumor necrosis factor receptor superfamily, member 1A	-	HPRD	11909948\|14743216
TNFRSF1B	CD120b \| TBPII \| TNF-R-II \| TNF-R75 \| TNFBR \| TNFR1B \| TNFR2 \| TNFR80 \| p75 \| p75TNFR	tumor necrosis factor receptor superfamily, member 1B	-	HPRD	14743216
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Hsc70 interacts with p53.	BIND	8940078
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Reconstituted Complex	BioGRID	11297531
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with an unspecified isoform of Hsc70. This interaction was modeled on a demonstrated interaction between human p53 and bovine Hsc70.	BIND	9235949
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	-	HPRD	14743216
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	-	HPRD	14743216
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	-	HPRD	14743216
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	-	HPRD	14743216
UBC	HMG20	ubiquitin C	Two-hybrid	BioGRID	16169070
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	-	HPRD	15324660

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG SPLICEOSOME	128	72	All SZGR 2.0 genes in this pathway
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION	89	65	All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY	82	63	All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY	84	61	All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING	129	74	All SZGR 2.0 genes in this pathway
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	60	31	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RELEASE CYCLE	34	30	All SZGR 2.0 genes in this pathway
REACTOME LYSOSOME VESICLE BIOGENESIS	23	11	All SZGR 2.0 genes in this pathway
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	53	27	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	17	16	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	50	All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	53	31	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS DN	51	35	All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP	112	71	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS MAGENTA UP	28	18	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR UP	27	19	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP	55	34	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN	214	133	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN	45	29	All SZGR 2.0 genes in this pathway
LANG MYB FAMILY TARGETS	29	16	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
APPIERTO RESPONSE TO FENRETINIDE UP	38	26	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 3	28	16	All SZGR 2.0 genes in this pathway
LUI TARGETS OF PAX8 PPARG FUSION	34	23	All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM DN	25	18	All SZGR 2.0 genes in this pathway
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN	87	48	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS	88	60	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC DN	31	23	All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 8HR 5 DN	11	8	All SZGR 2.0 genes in this pathway
BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR UP	25	17	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN	57	45	All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5	26	21	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN	169	102	All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS	53	35	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK	169	111	All SZGR 2.0 genes in this pathway
ZUCCHI METASTASIS UP	43	24	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN	245	154	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX DN	80	49	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP	69	41	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D5	39	26	All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE DN	46	29	All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN	64	44	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP	84	58	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP	71	48	All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP	45	33	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
VISALA RESPONSE TO HEAT SHOCK AND AGING DN	14	12	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS UP	102	64	All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG UP	41	26	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
KRISHNAN FURIN TARGETS UP	12	6	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP	51	32	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP	163	102	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN	181	97	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN	193	112	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
NIELSEN GIST	98	66	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M	216	124	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1	148	95	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2	73	37	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP	344	215	All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 DN	92	60	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-142-5p	172	179	1A,m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-33	201	207	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	201	207	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: HSPA8