Summary ?
GeneID3315
SymbolHSPB1
SynonymsCMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27
Descriptionheat shock protein family B (small) member 1
ReferenceMIM:602195|HGNC:HGNC:5246|Ensembl:ENSG00000106211|HPRD:09076|Vega:OTTHUMG00000023228
Gene typeprotein-coding
Map location7q11.23
Pascal p-value0.17
Sherlock p-value0.763
Fetal beta-0.113
eGeneMyers' cis & trans
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0143 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7607798chr2102043108HSPB133150.07trans
rs11722940chr4120233215HSPB133150.19trans
rs17595790chr4120276219HSPB133150.15trans
rs2700772chr85837584HSPB133150.08trans
rs2700770chr85837808HSPB133150.08trans
rs2247957chr85845867HSPB133150.18trans
rs108425570HSPB133150.03trans
rs7215675chr1710905819HSPB133150.08trans
rs16944595chr1711242834HSPB133150.13trans
rs2073206chr20948279HSPB133150.01trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0042802identical protein bindingIPI11003656 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006446regulation of translational initiationTAS10859165 
GO:0006986response to unfolded proteinTAS10859165 
GO:0006928cell motionTAS16130169 
GO:0006916anti-apoptosisTAS16130169 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonTAS16130169 
GO:0005634nucleusIEA-
GO:0005737cytoplasmTAS16130169 
GO:0009986cell surfaceIDA12493773 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1Affinity Capture-WesternBioGRID11042204 
C1orf103FLJ11269 | RIF1 | RP11-96K19.1chromosome 1 open reading frame 103Two-hybridBioGRID16169070 
C7orf64DKFZP564O0523 | DKFZp686D1651 | HSPC304chromosome 7 open reading frame 64Two-hybridBioGRID16169070 
CRYAACRYA1 | HSPB4crystallin, alpha A-HPRD,BioGRID11700327 
CRYABCRYA2 | CTPP2 | HSPB5crystallin, alpha B-HPRD,BioGRID1560006 |11700327 
CRYBB2CCA2 | CRYB2 | CRYB2A | D22S665crystallin, beta B2-HPRD,BioGRID11700327 
CRYGCCCL | CRYG3crystallin, gamma C-HPRD11700327 
CYCSCYC | HCScytochrome c, somaticAffinity Capture-WesternBioGRID11784858 
EIF4G1DKFZp686A1451 | EIF4F | EIF4G | p220eukaryotic translation initiation factor 4 gamma, 1-HPRD10859165 
HSPB8CMT2L | DHMN2 | E2IG1 | H11 | HMN2 | HMN2A | HSP22heat shock 22kDa protein 8-HPRD,BioGRID11342557 |14594798 
|15122253 
HSPB8CMT2L | DHMN2 | E2IG1 | H11 | HMN2 | HMN2A | HSP22heat shock 22kDa protein 8HSP22 interacts with HSP27.BIND14594798 
IGSF21FLJ41177 | MGC15730immunoglobin superfamily, member 21Two-hybridBioGRID16169070 
ILKDKFZp686F1765 | P59integrin-linked kinaseAffinity Capture-MSBioGRID17353931 
MAGED1DLXIN-1 | NRAGEmelanoma antigen family D, 1Affinity Capture-MSBioGRID17353931 
MAPKAPK2MK2mitogen-activated protein kinase-activated protein kinase 2-HPRD,BioGRID11042204 
MAPKAPK2MK2mitogen-activated protein kinase-activated protein kinase 2MK2 phosphorylates Hsp27. This interaction was modelled on a demonstrated interaction between human MK2 and Hsp27 from an unspecified species.BIND15692053 
MAPKAPK5PRAKmitogen-activated protein kinase-activated protein kinase 5-HPRD,BioGRID9628874 
MED313110004H13Rik | CGI-125 | FLJ27436 | FLJ36714 | Soh1mediator complex subunit 31Two-hybridBioGRID16169070 
POP70610037N12Rik | RPP2 | RPP20processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)Rpp20 interacts with Hsp27BIND11158571 
PPA1IOPPP | MGC111556 | PP | PP1 | SID6-8061pyrophosphatase (inorganic) 1Two-hybridBioGRID16169070 
TGFB1I1ARA55 | HIC-5 | HIC5 | TSC-5transforming growth factor beta 1 induced transcript 1Two-hybridBioGRID11546764 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 7653All SZGR 2.0 genes in this pathway
BIOCARTA MTA3 PATHWAY 1910All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY 4031All SZGR 2.0 genes in this pathway
BIOCARTA HSP27 PATHWAY 1511All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY 3728All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 6554All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY 2119All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY 3829All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284128All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 8450All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 5331All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481290All SZGR 2.0 genes in this pathway
TIMOFEEVA GROWTH STRESS VIA STAT1 DN 1612All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430232All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP 11966All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 8659All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 12686All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162116All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN GRANULOCYTE UP 159All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185126All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE UP 5534All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204140All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157104All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN MONOCYTE UP 2115All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP 4430All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN 4329All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316190All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 13694All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 11784All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239157All SZGR 2.0 genes in this pathway
STREICHER LSM1 TARGETS UP 4434All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
LI LUNG CANCER 4130All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178108All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330215All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS DN 2918All SZGR 2.0 genes in this pathway
STANHILL HRAS TRANSFROMATION UP 85All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN 2FC UP 147All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205126All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS UP 8451All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP 7856All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318215All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 5141All SZGR 2.0 genes in this pathway
DELLA RESPONSE TO TSA AND BUTYRATE 2117All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS 7147All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 30MIN 5436All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 7757All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 8858All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 9671All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP 4533All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 9071All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 10963All SZGR 2.0 genes in this pathway
HANN RESISTANCE TO BCL2 INHIBITOR DN 4831All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 14798All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D UP 8962All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 12284All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE 10176All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE 6751All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 15 3119All SZGR 2.0 genes in this pathway
VALK AML WITH CEBPA 3727All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE 8856All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207143All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
MIKHAYLOVA OXIDATIVE STRESS RESPONSE VIA VHL DN 65All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180116All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS UP 3516All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-53991971Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU