SZGR2

Summary ?

GeneID	3329
Symbol	HSPD1
Synonyms	CPN60\|GROEL\|HLD4\|HSP-60\|HSP60\|HSP65\|HuCHA60\|SPG13
Description	heat shock protein family D (Hsp60) member 1
Reference	MIM:118190\|HGNC:HGNC:5261\|Ensembl:ENSG00000144381\|HPRD:00318\|Vega:OTTHUMG00000154463
Gene type	protein-coding
Map location	2q33.1
Pascal p-value	7.58E-11
Sherlock p-value	0.591
Fetal beta	1.031
eGene	Myers' cis & trans
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin G2Cdb.human_mitochondria G2Cdb.human_Synaptosome G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.3026

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs12660028	chr5	74605501	HSPD1	3329	0.18	trans
rs1423526	chr5	74606172	HSPD1	3329	0.18	trans
rs16920160	chr8	55308290	HSPD1	3329	0.08	trans
rs10868543	chr9	89852686	HSPD1	3329	0.01	trans
rs10492782	chr16	13210707	HSPD1	3329	0.04	trans
rs9956108	chr18	3042415	HSPD1	3329	0.2	trans
rs8120542	chr20	24395092	HSPD1	3329	0.01	trans
rs8114637	chr20	24395207	HSPD1	3329	0.01	trans
rs4536719	chr20	24397114	HSPD1	3329	0.07	trans
rs9974024	chr20	24397274	HSPD1	3329	0.01	trans
rs6515493	chr20	24401635	HSPD1	3329	0.01	trans
rs6049703	chr20	24432425	HSPD1	3329	0.01	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0001530	lipopolysaccharide binding	IDA		17164250
GO:0002039	p53 binding	IPI		18086682
GO:0005524	ATP binding	IEA		-
GO:0051082	unfolded protein binding	IC		11050098
GO:0051087	chaperone binding	IPI		10205158
GO:0043498	cell surface binding	IDA		11807771
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IDA		16148103
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	IDA		10663613
GO:0002368	B cell cytokine production	IDA		16148103
GO:0006986	response to unfolded protein	IDA		11050098
GO:0006919	caspase activation	IDA		17823127
GO:0043065	positive regulation of apoptosis	IMP		17823127
GO:0042100	B cell proliferation	IDA		16148103
GO:0043066	negative regulation of apoptosis	IMP		18086682
GO:0050821	protein stabilization	IMP		18086682
GO:0050870	positive regulation of T cell activation	IDA		16148103 \|17164250
GO:0050870	positive regulation of T cell activation	ISS		-
GO:0042026	protein refolding	IDA		11050098
GO:0032735	positive regulation of interleukin-12 production	IDA		17164250
GO:0032733	positive regulation of interleukin-10 production	IDA		16148103
GO:0032729	positive regulation of interferon-gamma production	IDA		17164250
GO:0032727	positive regulation of interferon-alpha production	IDA		17164250
GO:0048291	isotype switching to IgG isotypes	IDA		16148103
GO:0032755	positive regulation of interleukin-6 production	IDA		16148103
GO:0043032	positive regulation of macrophage activation	IDA		17164250
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	IDA		18086682
GO:0005615	extracellular space	IDA		18229457
GO:0005739	mitochondrion	IDA		18086682
GO:0005743	mitochondrial inner membrane	IEA		-
GO:0005759	mitochondrial matrix	IEA		-
GO:0005769	early endosome	IDA		11807771
GO:0009986	cell surface	IDA		9243807
GO:0005905	coated pit	IDA		11807771
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	IDA		11445587
GO:0030135	coated vesicle	IDA		11807771
GO:0046696	lipopolysaccharide receptor complex	IDA		17164250

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ALDH2	ALDH-E2 \| ALDHI \| ALDM \| MGC1806	aldehyde dehydrogenase 2 family (mitochondrial)	-	HPRD,BioGRID	12387818
BAK1	BAK \| BAK-LIKE \| BCL2L7 \| CDN1 \| MGC117255 \| MGC3887	BCL2-antagonist/killer 1	-	HPRD,BioGRID	12070120
BAX	BCL2L4	BCL2-associated X protein	Affinity Capture-Western	BioGRID	12070120
CA2	CA-II \| CAII \| Car2	carbonic anhydrase II	-	HPRD,BioGRID	9890926 \|10811634
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	10205158 \|10205159
CASP6	MCH2	caspase 6, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	10205159
CASP9	APAF-3 \| APAF3 \| CASPASE-9c \| ICE-LAP6 \| MCH6	caspase 9, apoptosis-related cysteine peptidase	-	HPRD	11230124
DHFR	-	dihydrofolate reductase	-	HPRD,BioGRID	8559246 \|8976559
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	Affinity Capture-Western	BioGRID	11777905
HIST2H2BE	GL105 \| H2B \| H2B.1 \| H2B/q \| H2BFQ \| MGC119802 \| MGC119804 \| MGC129733 \| MGC129734	histone cluster 2, H2be	-	HPRD,BioGRID	9724719
HSPE1	CPN10 \| GROES \| HSP10	heat shock 10kDa protein 1 (chaperonin 10)	-	HPRD,BioGRID	10205158 \|11050098 \|12387818
KRAS	C-K-RAS \| K-RAS2A \| K-RAS2B \| K-RAS4A \| K-RAS4B \| KI-RAS \| KRAS1 \| KRAS2 \| NS3 \| RASK2	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	in vivo	BioGRID	11888933
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	Two-hybrid	BioGRID	10508170
PRNP	ASCR \| CD230 \| CJD \| GSS \| MGC26679 \| PRIP \| PrP \| PrP27-30 \| PrP33-35C \| PrPc \| prion	prion protein	PrPc interacts with HSPD1 (Hsp60). This interaction was modeled on a demonstrated interaction between hamster PrPc and human HSPD1 (Hsp60).	BIND	8676499
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD	1347942
SF3A2	PRP11 \| PRPF11 \| SAP62 \| SF3a66	splicing factor 3a, subunit 2, 66kDa	Affinity Capture-MS	BioGRID	12234937

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG RNA DEGRADATION	59	37	All SZGR 2.0 genes in this pathway
KEGG TYPE I DIABETES MELLITUS	44	38	All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY	79	62	All SZGR 2.0 genes in this pathway
PID TOLL ENDOGENOUS PATHWAY	25	19	All SZGR 2.0 genes in this pathway
REACTOME MITOCHONDRIAL PROTEIN IMPORT	58	24	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS	518	242	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN	92	51	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN	493	298	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP	408	247	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 UP	38	27	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN	244	147	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
CHOI ATL CHRONIC VS ACUTE DN	18	10	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP	204	140	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP	316	190	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN	378	231	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP	329	196	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN	185	115	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP	162	104	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP	147	101	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP	146	104	All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER	178	108	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM	159	93	All SZGR 2.0 genes in this pathway
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN	87	48	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP	110	71	All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP	201	127	All SZGR 2.0 genes in this pathway
SEMBA FHIT TARGETS UP	11	7	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
FALVELLA SMOKERS WITH LUNG CANCER	80	52	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A UP	77	49	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
LIU NASOPHARYNGEAL CARCINOMA	70	38	All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER A	100	63	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK	88	62	All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS	53	35	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN	85	56	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
COLLER MYC TARGETS UP	25	19	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP	45	30	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN	129	86	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE	64	47	All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE UP	38	23	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 2	72	52	All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C1	24	14	All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE	206	117	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS	90	71	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP	115	80	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP	295	149	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN	315	197	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002	429	260	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN	72	47	All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE DN	50	33	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP	85	50	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP	162	86	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS UP	127	78	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP	229	149	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
IKEDA MIR1 TARGETS DN	7	7	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS DN	27	24	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	235	241	m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-382	282	288	1A	hsa-miR-382^brain	GAAGUUGUUCGUGGUGGAUUCG
miR-421	295	301	1A	hsa-miR-421	GGCCUCAUUAAAUGUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: HSPD1